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- W4225528008 abstract "Objectives: Breast cancer is among the most commonly diagnosed cancers and one of the main causes of cancerrelated deaths in females. Long noncoding RNAs (lncRNA) are vital regulators of both oncogenesis and tumor suppression involved in crucial cancer pathways. Recent studies have demonstrated that LINC01296 and LINC00152 were aberrantly upregulated in different tumor types. In this study, we aimed to assess the expression levels of LINC01296 and LINC00152 in breast cancer and its adjacent tissues. Methods: Sample tissues were collected from 49 women with breast cancer referred to Shahid Faghihi Hospital in Shiraz for surgery from 2017 to 2018. Total RNA was extracted from fresh tumor and normal breast cancer tissues and expression of lncRNAs was assessed using real-time polymerase chain reaction. Results: A significant upregulation of LINC01296 and LINC00152 in breast cancer tissues compared with the adjacent normal tissues was observed (p<0.01). The Mann–Whitney analysis showed a significant relationship between the upregulation of LINC01296 and the use of oral contraceptives in luminal B breast cancer subjects (p=0.028). No significant relationship was found between the expression of LINC01296 and quantitative variables. Conclusion: This study showed an upregulation of LINC01296 and LINC00152 in breast cancer tissues compared with the adjacent normal tissues. Keywords: Breast cancer, Long noncoding RNA, LINC00152, LINC01296, Oral contraceptives" @default.
- W4225528008 created "2022-05-05" @default.
- W4225528008 creator A5078360778 @default.
- W4225528008 date "2022-01-01" @default.
- W4225528008 modified "2023-09-26" @default.
- W4225528008 title "Expression Levels of LINC01296 and LINC00152 in Breast Cancer Tissue: Association with the Use of Oral Contraceptives" @default.
- W4225528008 doi "https://doi.org/10.14744/ejmo.2022.33174" @default.
- W4225528008 hasPublicationYear "2022" @default.
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