FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225531508> ?p ?o ?g. }

• W4225531508 endingPage "513" @default.
• W4225531508 startingPage "505" @default.
• W4225531508 abstract "Laboratory study using a rat T9 contusion model of spinal cord injury.This study aims to examine whether a combinatory treatment of Pioglitazone (PGZ) and granulocyte colony-stimulating factor (GCSF) can support neural stem/progenitor cells (NSPCs) directly and provide a sustainable microenvironment through immunomodulatory mechanisms.Neuroinflammation plays a crucial role in the progression of spinal cord injury (SCI) and hinders NSPC-mediated repair and regeneration. Broad acting drugs that mitigate inflammation and support NSPC proliferation have not been tested together in SCI research models.Isolated NSPCs were treated with vehicle control, PGZ, GCSF, or both PGZ and GSCF for 24 hours and stained with proliferation marker Ki67. Adult female Sprague-Dawley rats sustained moderate-to-severe contusion-based SCI at T9 and were administered either vehicle control, PGZ, GCSF, or both PGZ and GCSF treatments.Immunocytochemistry revealed that cultured NSPCs treated with both drugs produced higher numbers of actively proliferating cells and total cell numbers. ELISA on spinal cord tissue lysates at 1, 3, and 7 days post-injury (DPI) demonstrated that animals treated with PGZ, GCSF, or combination therapy showed significantly higher doublecortin levels at 7 DPI compared to control animals (P < 0.05). Immunohistochemistry of injured tissue at 3, 7, and 14 DPI revealed no difference of ependymal NSPC proliferation between groups, but showed a significant decrease in lesion size with combination therapy compared to controls. Functional recovery was assessed by the Basso, Beattie, Bresnahan locomotor rating scale. Animals treated with both drugs had significantly higher levels of function at 1 (P < 0.001), 3 (P < 0.001), 7 (P < 0.05), and 14 (P < 0.05) DPI compared to controls.These results indicate that PGZ and GCSF treatment synergistically enhance NSPCs numbers and improve functional recovery after SCI. Our findings support an immunomodulatory strategy to recruit native NSPCs as a potential acute care intervention for SCI.Level of Evidence: N/A." @default.
• W4225531508 created "2022-05-05" @default.
• W4225531508 creator A5013881617 @default.
• W4225531508 creator A5046839697 @default.
• W4225531508 creator A5068980348 @default.
• W4225531508 creator A5078864295 @default.
• W4225531508 creator A5081445165 @default.
• W4225531508 date "2021-10-18" @default.
• W4225531508 modified "2023-09-27" @default.
• W4225531508 title "Pharmacologic Recruitment of Endogenous Neural Stem/Progenitor Cells for the Treatment of Spinal Cord Injury" @default.
• W4225531508 cites W1522897828 @default.
• W4225531508 cites W1785382835 @default.
• W4225531508 cites W1864727542 @default.
• W4225531508 cites W1968962277 @default.
• W4225531508 cites W1972647980 @default.
• W4225531508 cites W1974513180 @default.
• W4225531508 cites W1983437604 @default.
• W4225531508 cites W1989917860 @default.
• W4225531508 cites W2006517495 @default.
• W4225531508 cites W2009170266 @default.
• W4225531508 cites W2014941838 @default.
• W4225531508 cites W2016457100 @default.
• W4225531508 cites W2016748069 @default.
• W4225531508 cites W2029050019 @default.
• W4225531508 cites W2032413495 @default.
• W4225531508 cites W2033507194 @default.
• W4225531508 cites W2033978055 @default.
• W4225531508 cites W2054198357 @default.
• W4225531508 cites W2058089532 @default.
• W4225531508 cites W2059327333 @default.
• W4225531508 cites W2068681537 @default.
• W4225531508 cites W2070313328 @default.
• W4225531508 cites W2073874214 @default.
• W4225531508 cites W2127063807 @default.
• W4225531508 cites W2128475302 @default.
• W4225531508 cites W2128800519 @default.
• W4225531508 cites W2132918091 @default.
• W4225531508 cites W2136319115 @default.
• W4225531508 cites W2137259319 @default.
• W4225531508 cites W2139208934 @default.
• W4225531508 cites W2154104720 @default.
• W4225531508 cites W2168374306 @default.
• W4225531508 cites W2170645579 @default.
• W4225531508 cites W2261324572 @default.
• W4225531508 cites W2416730175 @default.
• W4225531508 cites W2471207432 @default.
• W4225531508 cites W2510435007 @default.
• W4225531508 cites W2608611322 @default.
• W4225531508 cites W3009940926 @default.
• W4225531508 doi "https://doi.org/10.1097/brs.0000000000004264" @default.
• W4225531508 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34669674" @default.
• W4225531508 hasPublicationYear "2021" @default.
• W4225531508 type Work @default.
• W4225531508 citedByCount "2" @default.
• W4225531508 countsByYear W42255315082023 @default.
• W4225531508 crossrefType "journal-article" @default.
• W4225531508 hasAuthorship W4225531508A5013881617 @default.
• W4225531508 hasAuthorship W4225531508A5046839697 @default.
• W4225531508 hasAuthorship W4225531508A5068980348 @default.
• W4225531508 hasAuthorship W4225531508A5078864295 @default.
• W4225531508 hasAuthorship W4225531508A5081445165 @default.
• W4225531508 hasConcept C118552586 @default.
• W4225531508 hasConcept C126322002 @default.
• W4225531508 hasConcept C136834591 @default.
• W4225531508 hasConcept C142724271 @default.
• W4225531508 hasConcept C164027704 @default.
• W4225531508 hasConcept C171056886 @default.
• W4225531508 hasConcept C201750760 @default.
• W4225531508 hasConcept C204232928 @default.
• W4225531508 hasConcept C25498285 @default.
• W4225531508 hasConcept C2776914184 @default.
• W4225531508 hasConcept C2778334475 @default.
• W4225531508 hasConcept C2780775167 @default.
• W4225531508 hasConcept C2781156865 @default.
• W4225531508 hasConcept C28328180 @default.
• W4225531508 hasConcept C71924100 @default.
• W4225531508 hasConcept C86803240 @default.
• W4225531508 hasConcept C95444343 @default.
• W4225531508 hasConcept C98274493 @default.
• W4225531508 hasConceptScore W4225531508C118552586 @default.
• W4225531508 hasConceptScore W4225531508C126322002 @default.
• W4225531508 hasConceptScore W4225531508C136834591 @default.
• W4225531508 hasConceptScore W4225531508C142724271 @default.
• W4225531508 hasConceptScore W4225531508C164027704 @default.
• W4225531508 hasConceptScore W4225531508C171056886 @default.
• W4225531508 hasConceptScore W4225531508C201750760 @default.
• W4225531508 hasConceptScore W4225531508C204232928 @default.
• W4225531508 hasConceptScore W4225531508C25498285 @default.
• W4225531508 hasConceptScore W4225531508C2776914184 @default.
• W4225531508 hasConceptScore W4225531508C2778334475 @default.
• W4225531508 hasConceptScore W4225531508C2780775167 @default.
• W4225531508 hasConceptScore W4225531508C2781156865 @default.
• W4225531508 hasConceptScore W4225531508C28328180 @default.
• W4225531508 hasConceptScore W4225531508C71924100 @default.
• W4225531508 hasConceptScore W4225531508C86803240 @default.
• W4225531508 hasConceptScore W4225531508C95444343 @default.
• W4225531508 hasConceptScore W4225531508C98274493 @default.
• W4225531508 hasIssue "6" @default.

• next