Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225533067> ?p ?o ?g. }
- W4225533067 abstract "Abstract Background Oxidative stress contributes to retina ganglion cells (RGCs) loss in variety of ocular diseases, including ocular trauma, ocular vein occlusion, and glaucoma. Scavenging the excessed reactive oxygen species (ROS) in retinal neurovascular unit could be beneficial to RGCs survival. In this study, a polydopamine (PDA)-based nanoplatform is developed to protect RGCs. Results The PDA nanoparticles efficiently eliminate multi-types of ROS, protect endothelia and neuronal cells from oxidative damage, and inhibit microglia activation in retinas. In an optic nerve crush (ONC) model, single intravitreal injection of PDA nanoparticles could significantly attenuate RGCs loss via eliminating ROS in retinas, reducing the inflammatory response and maintaining barrier function of retinal vascular endothelia. Comparative transcriptome analysis of the retina implied that PDA nanoparticles improve RGCs survival probably by altering the expression of genes involved in inflammation and ROS production. Importantly, as a versatile drug carrier, PDA nanoparticles could deliver brimonidine (a neuroprotection drug) to synergistically attenuate RGCs loss and promote axon regeneration, thus restore visual function. Conclusions The PDA nanoparticle-based therapeutic nanoplatform displayed excellent performance in ROS elimination, providing a promising probability for treating retinal degeneration diseases. Graphical Abstract" @default.
- W4225533067 created "2022-05-05" @default.
- W4225533067 creator A5007578231 @default.
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- W4225533067 creator A5045914285 @default.
- W4225533067 creator A5057117256 @default.
- W4225533067 creator A5069849278 @default.
- W4225533067 date "2021-12-20" @default.
- W4225533067 modified "2023-10-16" @default.
- W4225533067 title "Polydopamine nanoparticles attenuate retina ganglion cell degeneration and restore visual function after optic nerve injury" @default.
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- W4225533067 doi "https://doi.org/10.1186/s12951-021-01199-3" @default.
- W4225533067 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34930292" @default.
- W4225533067 hasPublicationYear "2021" @default.
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