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- W4225533688 endingPage "430" @default.
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- W4225533688 abstract "Chronic HCV infection progresses to fibrosis, cirrhosis and hepatocellular carcinoma (HCC). The latter represents the third most common cause for cancer mortality. Currently, there is no reliable non-invasive biomarker for diagnosis of HCV mediated disorders.Profiling expression signature for circulatory miRNAs in the plasma of 167 Egyptian patients (40 healthy, 48 HCV fibrotic, 39 HCV cirrhotic and 40 HCV-HCC cases).QRTPCR was used to quantify expression signature for circulatory miRNAs.MiR-676 and miR-650 were powerful in discriminating cirrhotic and late fibrosis from HCC. MiR-650 could distinguish mild (f0-f1) and advanced (f2-f3) fibrosis from HCC cases. MiR-650 and miR-147b could distinguish early fibrosis from healthy controls meanwhile miR-676 and miR-147b could effectively distinguish between mild chronic and (f1-f3) cases from healthy individuals. All studied miRNAs, except miR-512, can differentiate between (f0-f3) cases and healthy controls. Multivariate logistic regression revealed three potential miRNA panels for effective differentiation of HCC, cirrhotic and chronic liver cases. MiR-676-3p and miR-512-5p were significantly correlated in (f1-f3) fibrosis meanwhile miR-676 and miR-512 could differentiate between cirrhosis and (f0-f3) cases. Both miR-650 and miR-512-5p were positively correlated in the cirrhotic group and in (f0-f4) group. Putative targets for investigated miRNAs were also determined.Investigated miRNAs could assist in staging and diagnosis of HCV associated disorders." @default.
- W4225533688 created "2022-05-05" @default.
- W4225533688 creator A5001270517 @default.
- W4225533688 creator A5023038466 @default.
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- W4225533688 creator A5037906942 @default.
- W4225533688 creator A5039635084 @default.
- W4225533688 creator A5049874687 @default.
- W4225533688 creator A5072916408 @default.
- W4225533688 date "2022-05-13" @default.
- W4225533688 modified "2023-09-27" @default.
- W4225533688 title "Diagnosis and staging of HCV associated fibrosis, cirrhosis and hepatocellular carcinoma with target identification for miR-650, 552-3p, 676-3p, 512-5p and 147b" @default.
- W4225533688 cites W1197903873 @default.
- W4225533688 cites W1604557454 @default.
- W4225533688 cites W1606475998 @default.
- W4225533688 cites W1834098278 @default.
- W4225533688 cites W1956123433 @default.
- W4225533688 cites W1967541170 @default.
- W4225533688 cites W1975437957 @default.
- W4225533688 cites W1981425965 @default.
- W4225533688 cites W1983780695 @default.
- W4225533688 cites W1990552018 @default.
- W4225533688 cites W1991924671 @default.
- W4225533688 cites W1995000770 @default.
- W4225533688 cites W1995180061 @default.
- W4225533688 cites W1996462805 @default.
- W4225533688 cites W1998256799 @default.
- W4225533688 cites W1998931389 @default.
- W4225533688 cites W2004076913 @default.
- W4225533688 cites W2009303202 @default.
- W4225533688 cites W2010461414 @default.
- W4225533688 cites W2012475096 @default.
- W4225533688 cites W2015356857 @default.
- W4225533688 cites W2020830322 @default.
- W4225533688 cites W2022667041 @default.
- W4225533688 cites W2028831862 @default.
- W4225533688 cites W2041357724 @default.
- W4225533688 cites W2054944115 @default.
- W4225533688 cites W2066682520 @default.
- W4225533688 cites W2070300061 @default.
- W4225533688 cites W2078990494 @default.
- W4225533688 cites W2086476247 @default.
- W4225533688 cites W2088544203 @default.
- W4225533688 cites W2097233439 @default.
- W4225533688 cites W2102778267 @default.
- W4225533688 cites W2111456931 @default.
- W4225533688 cites W2112157191 @default.
- W4225533688 cites W2113047680 @default.
- W4225533688 cites W2115093090 @default.
- W4225533688 cites W2121966578 @default.
- W4225533688 cites W2122417281 @default.
- W4225533688 cites W2123079914 @default.
- W4225533688 cites W2128796736 @default.
- W4225533688 cites W2133036275 @default.
- W4225533688 cites W2153271206 @default.
- W4225533688 cites W2159680353 @default.
- W4225533688 cites W2160564184 @default.
- W4225533688 cites W2162769953 @default.
- W4225533688 cites W2163482204 @default.
- W4225533688 cites W2169489859 @default.
- W4225533688 cites W2171931307 @default.
- W4225533688 cites W2321919886 @default.
- W4225533688 cites W2461837617 @default.
- W4225533688 cites W2523230485 @default.
- W4225533688 cites W2546422858 @default.
- W4225533688 cites W2553485012 @default.
- W4225533688 cites W2560936010 @default.
- W4225533688 cites W2565367159 @default.
- W4225533688 cites W2592349172 @default.
- W4225533688 cites W2608181902 @default.
- W4225533688 cites W2612866636 @default.
- W4225533688 cites W2755620106 @default.
- W4225533688 cites W2773673124 @default.
- W4225533688 cites W2783654592 @default.
- W4225533688 cites W2790938901 @default.
- W4225533688 cites W2800788063 @default.
- W4225533688 cites W2804356958 @default.
- W4225533688 cites W2810090816 @default.
- W4225533688 cites W2884097717 @default.
- W4225533688 cites W2885054823 @default.
- W4225533688 cites W2885253646 @default.
- W4225533688 cites W2887200576 @default.
- W4225533688 cites W2890373972 @default.
- W4225533688 cites W2891433775 @default.
- W4225533688 cites W2893775712 @default.
- W4225533688 cites W2896414578 @default.
- W4225533688 cites W2896442590 @default.
- W4225533688 cites W2899548289 @default.
- W4225533688 cites W2903176015 @default.
- W4225533688 cites W2905282659 @default.
- W4225533688 cites W2907813288 @default.
- W4225533688 cites W2911285631 @default.
- W4225533688 cites W2945480548 @default.
- W4225533688 cites W2953476289 @default.
- W4225533688 cites W2955417462 @default.
- W4225533688 cites W2957293676 @default.
- W4225533688 cites W2976399137 @default.
- W4225533688 cites W2983785394 @default.