Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225533703> ?p ?o ?g. }
- W4225533703 abstract "Blood-brain-barrier (BBB) dysfunction is a hallmark of aging and aging-related disorders, including cerebral small vessel disease and Alzheimer's disease. An emerging biomarker of BBB dysfunction is BBB water exchange rate (kW) as measured by diffusion-weighted arterial spin labeling (DW-ASL) MRI. We developed an improved DW-ASL sequence for Quantitative Permeability Mapping and evaluated whole brain and region-specific kW in a cohort of 30 adults without dementia across the age spectrum. In this cross-sectional study, we found higher kW values in the cerebral cortex (mean = 81.51 min-1, SD = 15.54) compared to cerebral white matter (mean = 75.19 min-1, SD = 13.85) (p < 0.0001). We found a similar relationship for cerebral blood flow (CBF), concordant with previously published studies. Multiple linear regression analysis with kW as an outcome showed that age was statistically significant in the cerebral cortex (p = 0.013), cerebral white matter (p = 0.033), hippocampi (p = 0.043), orbitofrontal cortices (p = 0.042), and precunei cortices (p = 0.009), after adjusting for sex and number of vascular risk factors. With CBF as an outcome, age was statistically significant only in the cerebral cortex (p = 0.026) and precunei cortices (p = 0.020). We further found moderate negative correlations between white matter hyperintensity (WMH) kW and WMH volume (r = -0.51, p = 0.02), and normal-appearing white matter (NAWM) and WMH volume (r = -0.44, p = 0.05). This work illuminates the relationship between BBB water exchange and aging and may serve as the basis for BBB-targeted therapies for aging-related brain disorders." @default.
- W4225533703 created "2022-05-05" @default.
- W4225533703 creator A5011302117 @default.
- W4225533703 creator A5016683007 @default.
- W4225533703 creator A5016856927 @default.
- W4225533703 creator A5024618722 @default.
- W4225533703 creator A5054660298 @default.
- W4225533703 creator A5058285158 @default.
- W4225533703 creator A5059916379 @default.
- W4225533703 creator A5084309318 @default.
- W4225533703 date "2022-04-08" @default.
- W4225533703 modified "2023-10-06" @default.
- W4225533703 title "Quantitative Water Permeability Mapping of Blood-Brain-Barrier Dysfunction in Aging" @default.
- W4225533703 cites W106908657 @default.
- W4225533703 cites W128151115 @default.
- W4225533703 cites W1495656315 @default.
- W4225533703 cites W1570296238 @default.
- W4225533703 cites W1598901374 @default.
- W4225533703 cites W1704947773 @default.
- W4225533703 cites W1957400240 @default.
- W4225533703 cites W1961948883 @default.
- W4225533703 cites W1969292798 @default.
- W4225533703 cites W1978043326 @default.
- W4225533703 cites W1992883702 @default.
- W4225533703 cites W2000929237 @default.
- W4225533703 cites W2003861703 @default.
- W4225533703 cites W2004344916 @default.
- W4225533703 cites W2015541518 @default.
- W4225533703 cites W2022931805 @default.
- W4225533703 cites W2031187292 @default.
- W4225533703 cites W2031275782 @default.
- W4225533703 cites W2031604650 @default.
- W4225533703 cites W2031978470 @default.
- W4225533703 cites W2034275438 @default.
- W4225533703 cites W2035702829 @default.
- W4225533703 cites W2040032797 @default.
- W4225533703 cites W2046611979 @default.
- W4225533703 cites W2052414593 @default.
- W4225533703 cites W2052644075 @default.
- W4225533703 cites W2055467683 @default.
- W4225533703 cites W2056316680 @default.
- W4225533703 cites W2061128714 @default.
- W4225533703 cites W2066840018 @default.
- W4225533703 cites W2073122489 @default.
- W4225533703 cites W2073923875 @default.
- W4225533703 cites W2075485349 @default.
- W4225533703 cites W2075648305 @default.
- W4225533703 cites W2076516398 @default.
- W4225533703 cites W2077466520 @default.
- W4225533703 cites W2080105610 @default.
- W4225533703 cites W2081429960 @default.
- W4225533703 cites W2093271288 @default.
- W4225533703 cites W2094234889 @default.
- W4225533703 cites W2096230518 @default.
- W4225533703 cites W2096525076 @default.
- W4225533703 cites W2099448948 @default.
- W4225533703 cites W2100314515 @default.
- W4225533703 cites W2105112166 @default.
- W4225533703 cites W2106468847 @default.
- W4225533703 cites W2109290881 @default.
- W4225533703 cites W2116641010 @default.
- W4225533703 cites W211905087 @default.
- W4225533703 cites W2119734225 @default.
- W4225533703 cites W2125358722 @default.
- W4225533703 cites W2125414248 @default.
- W4225533703 cites W2127890285 @default.
- W4225533703 cites W2131466516 @default.
- W4225533703 cites W2136317345 @default.
- W4225533703 cites W2136421454 @default.
- W4225533703 cites W2151721316 @default.
- W4225533703 cites W2157032372 @default.
- W4225533703 cites W2161518657 @default.
- W4225533703 cites W2162611158 @default.
- W4225533703 cites W2165758561 @default.
- W4225533703 cites W2167183660 @default.
- W4225533703 cites W2167945792 @default.
- W4225533703 cites W2168542458 @default.
- W4225533703 cites W2168558768 @default.
- W4225533703 cites W2415637550 @default.
- W4225533703 cites W2463178627 @default.
- W4225533703 cites W2531608968 @default.
- W4225533703 cites W2542587438 @default.
- W4225533703 cites W2559691789 @default.
- W4225533703 cites W2565314027 @default.
- W4225533703 cites W2565609152 @default.
- W4225533703 cites W2570795731 @default.
- W4225533703 cites W2735069571 @default.
- W4225533703 cites W2768030986 @default.
- W4225533703 cites W2770950271 @default.
- W4225533703 cites W2786608785 @default.
- W4225533703 cites W2790798430 @default.
- W4225533703 cites W2792673284 @default.
- W4225533703 cites W2801529879 @default.
- W4225533703 cites W2804443444 @default.
- W4225533703 cites W2807474935 @default.
- W4225533703 cites W2810370774 @default.
- W4225533703 cites W2811101553 @default.
- W4225533703 cites W2884933563 @default.
- W4225533703 cites W2887028711 @default.
- W4225533703 cites W2891781570 @default.