FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225535320> ?p ?o ?g. }

• W4225535320 endingPage "524" @default.
• W4225535320 startingPage "519" @default.
• W4225535320 abstract "Aim: T-regulatory (Treg)/T-helper (Th) 17 imbalance contributes to the pathogenesis of allergic rhinitis (AR). Long non-coding RNAs (lncRNAs) participate in the progression of AR. Herein, the effect of lncRNA JP X on Treg/Th17 balance in AR was explored.Methods: CD4+ T cells were isolated from patients with AR and healthy control. The percentage of Treg and Th17 cells were examined by flow cytometry. The levels of JP X, miR-378g, CCL5, T GF-β, and IL-17A were tested using qRT-P CR. The protein expression of Foxp3 and RORγt was measured by western blot.Results: The data showed that an imbalance of Treg/Th17 was associated with AR. Upregulation of JP X was found in AR, and knockdown of which improved the imbalance of Treg/Th17. Furthermore, JP X functioned as a sponge of miR-378g to upregulate CCL5. Inhibition of miR-378g reversed the effects on Treg/Th17 induced by silencing of JP X. Moreover, overexpression of CCL5 reversed miR-378g-induced effects.Conclusion: In conclusion, depletion of JP X promoted Treg/Th17 balance in AR via regulating the miR-378g/CCL5 axis. The findings provided a novel therapeutic insight for AR." @default.
• W4225535320 created "2022-05-05" @default.
• W4225535320 creator A5005099065 @default.
• W4225535320 creator A5013702415 @default.
• W4225535320 creator A5057054344 @default.
• W4225535320 creator A5062451261 @default.
• W4225535320 creator A5088964042 @default.
• W4225535320 date "2022-04-06" @default.
• W4225535320 modified "2023-10-18" @default.
• W4225535320 title "LncRNA JPX contributes to Treg/Th17 imbalance in allergic rhinitis <i>via</i> targeting the miR-378g/CCL5 axis" @default.
• W4225535320 cites W1966226308 @default.
• W4225535320 cites W1973755752 @default.
• W4225535320 cites W2021340905 @default.
• W4225535320 cites W2022267899 @default.
• W4225535320 cites W2065391064 @default.
• W4225535320 cites W2076588711 @default.
• W4225535320 cites W2149710757 @default.
• W4225535320 cites W2165273254 @default.
• W4225535320 cites W2173172085 @default.
• W4225535320 cites W2278886251 @default.
• W4225535320 cites W2399472917 @default.
• W4225535320 cites W2519292031 @default.
• W4225535320 cites W2565788901 @default.
• W4225535320 cites W2625411163 @default.
• W4225535320 cites W2791371888 @default.
• W4225535320 cites W2810758772 @default.
• W4225535320 cites W2898582380 @default.
• W4225535320 cites W2944941526 @default.
• W4225535320 cites W2956356077 @default.
• W4225535320 cites W2972376685 @default.
• W4225535320 cites W2981183570 @default.
• W4225535320 cites W2994802995 @default.
• W4225535320 cites W2996529081 @default.
• W4225535320 cites W3000371577 @default.
• W4225535320 cites W3044020020 @default.
• W4225535320 cites W3047618978 @default.
• W4225535320 cites W3102288720 @default.
• W4225535320 cites W3127753327 @default.
• W4225535320 cites W3173234323 @default.
• W4225535320 cites W4229553561 @default.
• W4225535320 cites W4231411345 @default.
• W4225535320 cites W4231424293 @default.
• W4225535320 doi "https://doi.org/10.1080/08923973.2022.2055566" @default.
• W4225535320 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35387544" @default.
• W4225535320 hasPublicationYear "2022" @default.
• W4225535320 type Work @default.
• W4225535320 citedByCount "5" @default.
• W4225535320 countsByYear W42255353202022 @default.
• W4225535320 countsByYear W42255353202023 @default.
• W4225535320 crossrefType "journal-article" @default.
• W4225535320 hasAuthorship W4225535320A5005099065 @default.
• W4225535320 hasAuthorship W4225535320A5013702415 @default.
• W4225535320 hasAuthorship W4225535320A5057054344 @default.
• W4225535320 hasAuthorship W4225535320A5062451261 @default.
• W4225535320 hasAuthorship W4225535320A5088964042 @default.
• W4225535320 hasBestOaLocation W42255353202 @default.
• W4225535320 hasConcept C104317684 @default.
• W4225535320 hasConcept C116484652 @default.
• W4225535320 hasConcept C119056186 @default.
• W4225535320 hasConcept C127561419 @default.
• W4225535320 hasConcept C173396325 @default.
• W4225535320 hasConcept C185592680 @default.
• W4225535320 hasConcept C203014093 @default.
• W4225535320 hasConcept C2776090121 @default.
• W4225535320 hasConcept C2776415932 @default.
• W4225535320 hasConcept C2779727006 @default.
• W4225535320 hasConcept C2780942790 @default.
• W4225535320 hasConcept C3020684253 @default.
• W4225535320 hasConcept C502942594 @default.
• W4225535320 hasConcept C553184892 @default.
• W4225535320 hasConcept C55493867 @default.
• W4225535320 hasConcept C74737994 @default.
• W4225535320 hasConcept C79484868 @default.
• W4225535320 hasConcept C86803240 @default.
• W4225535320 hasConcept C8891405 @default.
• W4225535320 hasConceptScore W4225535320C104317684 @default.
• W4225535320 hasConceptScore W4225535320C116484652 @default.
• W4225535320 hasConceptScore W4225535320C119056186 @default.
• W4225535320 hasConceptScore W4225535320C127561419 @default.
• W4225535320 hasConceptScore W4225535320C173396325 @default.
• W4225535320 hasConceptScore W4225535320C185592680 @default.
• W4225535320 hasConceptScore W4225535320C203014093 @default.
• W4225535320 hasConceptScore W4225535320C2776090121 @default.
• W4225535320 hasConceptScore W4225535320C2776415932 @default.
• W4225535320 hasConceptScore W4225535320C2779727006 @default.
• W4225535320 hasConceptScore W4225535320C2780942790 @default.
• W4225535320 hasConceptScore W4225535320C3020684253 @default.
• W4225535320 hasConceptScore W4225535320C502942594 @default.
• W4225535320 hasConceptScore W4225535320C553184892 @default.
• W4225535320 hasConceptScore W4225535320C55493867 @default.
• W4225535320 hasConceptScore W4225535320C74737994 @default.
• W4225535320 hasConceptScore W4225535320C79484868 @default.
• W4225535320 hasConceptScore W4225535320C86803240 @default.
• W4225535320 hasConceptScore W4225535320C8891405 @default.
• W4225535320 hasIssue "4" @default.
• W4225535320 hasLocation W42255353201 @default.
• W4225535320 hasLocation W42255353202 @default.
• W4225535320 hasLocation W42255353203 @default.

• next