FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225535736> ?p ?o ?g. }

• W4225535736 endingPage "495" @default.
• W4225535736 startingPage "483" @default.
• W4225535736 abstract "Post-stroke depression (PSD), the most frequent psychiatric complication following stroke, could have a negative impact on the recuperation of stroke patients. Hyperhomocysteinemia (HHCY) has been reported to be a modifiable risk factor of stroke.The study tries to explore the effect of HHCY on PSD and the role of N-methyl-d-aspartate receptors (NMDARs)-mediated synaptic alterations.Forty-five adult male Sprague-Dawley rats were randomly allocated into five groups: sham operation group, middle cerebral artery occlusion group (MCAO), HCY-treated MCAO group HCY and MK-801 co-treated MCAO group and MK-801-treated MCAO group. 1.6 mg/kg/d D, L-HCY was administered by tail vein injection for 28 d prior to SHAM or MCAO operationand up to 14 d after surgery. The MK-801 (3 mg/kg) was administered by intraperitoneal injection 15 min prior to MCAO operation.HCY treatment aggravated depressive-like disorders of post-stroke rats by the open field test and sucrose preference test. Further, HCY significantly decreased central monoamines levels in the MCAO rats by HPLC. The transmission electron microscopy results showed that the number of synapses and the area of postsynaptic density decreased in the hippocampus of the HCY-treated MCAO rats. Additionally, HCY augmented ischemia-induced up-regulation of NMDARs, decreased the levels of synaptic structure-related marker PSD-95and the synaptic transmission-associated synaptic proteins (VGLUT1, SNAP-25 and Complexin Ι/ΙΙ). These effects of HCY were partly reversed by the NMDA antagonist MK-801.The current study suggested that NMDARs-mediated synaptic plasticity may be involved in the adverse effect of HCY on PSD." @default.
• W4225535736 created "2022-05-05" @default.
• W4225535736 creator A5007348590 @default.
• W4225535736 creator A5010705736 @default.
• W4225535736 creator A5013881064 @default.
• W4225535736 creator A5039837606 @default.
• W4225535736 creator A5062508997 @default.
• W4225535736 creator A5081515655 @default.
• W4225535736 creator A5086428144 @default.
• W4225535736 creator A5088149597 @default.
• W4225535736 date "2023-06-01" @default.
• W4225535736 modified "2023-09-26" @default.
• W4225535736 title "Homocysteine can aggravate depressive like behaviors in a middle cerebral artery occlusion/reperfusion rat model: a possible role for NMDARs-mediated synaptic alterations." @default.
• W4225535736 cites W1558113371 @default.
• W4225535736 cites W1878092990 @default.
• W4225535736 cites W1986526277 @default.
• W4225535736 cites W1997504942 @default.
• W4225535736 cites W2003982930 @default.
• W4225535736 cites W2004897596 @default.
• W4225535736 cites W2017101987 @default.
• W4225535736 cites W2024380057 @default.
• W4225535736 cites W2028772345 @default.
• W4225535736 cites W2039059998 @default.
• W4225535736 cites W2040733203 @default.
• W4225535736 cites W2040965283 @default.
• W4225535736 cites W2054115147 @default.
• W4225535736 cites W2063852510 @default.
• W4225535736 cites W2074602389 @default.
• W4225535736 cites W2083004303 @default.
• W4225535736 cites W2090057750 @default.
• W4225535736 cites W2091869067 @default.
• W4225535736 cites W2097392023 @default.
• W4225535736 cites W2112505121 @default.
• W4225535736 cites W2114577396 @default.
• W4225535736 cites W2121349585 @default.
• W4225535736 cites W2128246609 @default.
• W4225535736 cites W2134479104 @default.
• W4225535736 cites W2141114982 @default.
• W4225535736 cites W2149612111 @default.
• W4225535736 cites W2158031806 @default.
• W4225535736 cites W2163012780 @default.
• W4225535736 cites W2166648854 @default.
• W4225535736 cites W2167465511 @default.
• W4225535736 cites W2195779068 @default.
• W4225535736 cites W2500152691 @default.
• W4225535736 cites W2511226519 @default.
• W4225535736 cites W2520524398 @default.
• W4225535736 cites W2531747075 @default.
• W4225535736 cites W2546512774 @default.
• W4225535736 cites W2550308261 @default.
• W4225535736 cites W2607653777 @default.
• W4225535736 cites W2754991698 @default.
• W4225535736 cites W2766336227 @default.
• W4225535736 cites W2770631390 @default.
• W4225535736 cites W2783911336 @default.
• W4225535736 cites W2792925662 @default.
• W4225535736 cites W2797431083 @default.
• W4225535736 cites W2873457490 @default.
• W4225535736 cites W2893294047 @default.
• W4225535736 cites W2952344926 @default.
• W4225535736 cites W2964274053 @default.
• W4225535736 cites W2985795775 @default.
• W4225535736 cites W3049130973 @default.
• W4225535736 cites W3093263106 @default.
• W4225535736 cites W3157921964 @default.
• W4225535736 doi "https://doi.org/10.1080/1028415x.2022.2060642" @default.
• W4225535736 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35416761" @default.
• W4225535736 hasPublicationYear "2023" @default.
• W4225535736 type Work @default.
• W4225535736 citedByCount "4" @default.
• W4225535736 countsByYear W42255357362022 @default.
• W4225535736 countsByYear W42255357362023 @default.
• W4225535736 crossrefType "journal-article" @default.
• W4225535736 hasAuthorship W4225535736A5007348590 @default.
• W4225535736 hasAuthorship W4225535736A5010705736 @default.
• W4225535736 hasAuthorship W4225535736A5013881064 @default.
• W4225535736 hasAuthorship W4225535736A5039837606 @default.
• W4225535736 hasAuthorship W4225535736A5062508997 @default.
• W4225535736 hasAuthorship W4225535736A5081515655 @default.
• W4225535736 hasAuthorship W4225535736A5086428144 @default.
• W4225535736 hasAuthorship W4225535736A5088149597 @default.
• W4225535736 hasConcept C126322002 @default.
• W4225535736 hasConcept C127413603 @default.
• W4225535736 hasConcept C134018914 @default.
• W4225535736 hasConcept C170493617 @default.
• W4225535736 hasConcept C187541742 @default.
• W4225535736 hasConcept C197341189 @default.
• W4225535736 hasConcept C200170125 @default.
• W4225535736 hasConcept C2776523773 @default.
• W4225535736 hasConcept C2777090595 @default.
• W4225535736 hasConcept C2780645631 @default.
• W4225535736 hasConcept C2781161787 @default.
• W4225535736 hasConcept C42219234 @default.
• W4225535736 hasConcept C67018056 @default.
• W4225535736 hasConcept C71924100 @default.
• W4225535736 hasConcept C78519656 @default.
• W4225535736 hasConcept C98229152 @default.
• W4225535736 hasConceptScore W4225535736C126322002 @default.

• next