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• W4225536325 endingPage "110624" @default.
• W4225536325 startingPage "110624" @default.
• W4225536325 abstract "Neurexins (NRXNs) are key presynaptic cell adhesion molecules that regulate synapse formation and function via trans-synaptic interaction with postsynaptic ligands. Here, we generate cerebellar granule cell (CGC)-specific Nrxn triple-knockout (TKO) mice for complete deletion of all NRXNs. Unexpectedly, most CGCs die in these mice, and this requirement for NRXNs for cell survival is reproduced in cultured CGCs. The axons of cultured Nrxn TKO CGCs that are not in contact with a postsynaptic structure show defects in the formation of presynaptic protein clusters and in action-potential-induced Ca2+ influxes. These cells also show impaired secretion of depolarization-induced, fluorescence-tagged brain-derived neurotrophic factor (BDNF) from their axons, and the cell-survival defect is rescued by the application of BDNF. These results suggest that CGC survival is maintained by autocrine neurotrophic factors and that NRXNs organize the presynaptic protein clusters and the autocrine neurotrophic-factor secretory machinery independent of contact with postsynaptic ligands." @default.
• W4225536325 created "2022-05-05" @default.
• W4225536325 creator A5001216456 @default.
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• W4225536325 date "2022-04-01" @default.
• W4225536325 modified "2023-10-14" @default.
• W4225536325 title "Neurexins play a crucial role in cerebellar granule cell survival by organizing autocrine machinery for neurotrophins" @default.
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• W4225536325 doi "https://doi.org/10.1016/j.celrep.2022.110624" @default.

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