FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225539137> ?p ?o ?g. }

• W4225539137 endingPage "520" @default.
• W4225539137 startingPage "504" @default.
• W4225539137 abstract "Lymphangiogenesis, the generation of new lymphatic vessels from existing ones, results from the dynamic interactions of lymphatic endothelial cells and the tumor microenvironment (TME). It is well known that lymphangiogenesis occurs during the initial stage of metastasis in various types of malignant tumors. However, it is currently not used as a biomarker partially because gold standard method to quantify it is labor and cost intensive. We hypothesized that the quantity of intratumoral lymphatic endothelial cells (iLECs) in the TME is an indicator of lymphangiogenesis and a predictor of metastatic potential and overall survival in breast cancer. We analyzed a total of 4145 breast cancer patients from the Cancer Genome Atlas (TCGA) and GSE96058 by quantifying their iLECs using the xCell algorithm, and correlated these scores with patient survival, tumor grade, and cancer stage. We also assessed various pro- and anti-cancer gene sets for each tumor to characterize tumor behavior and aggressiveness. As we expected, high-iLEC breast cancer demonstrated enriched lymphoangiogenesis and angiogenesis gene sets and was associated with increased expressions of related genes. Also enriched were inflammatory response and immune response-related gene sets; IL2/STAT5 pathway, IL6/JAK/STAT3 pathway, TNFα pathway, allograft rejection, and complement as well as cancer stemness related gene sets like Notch signaling, Hedgehog signaling, epithelial mesenchymal transition, and Wnt beta-catenin signaling. Tumors with high-iLEC showed higher proportions of stromal cells and fewer anti-cancer immune cells. On the other hand, iLEC score did not correlate with patient survival or lymph node metastasis. Surprisingly, breast cancers with fewer iLECs demonstrated enriched E2F Targets, G2M Checkpoint, MYC Targets v1, and MTORC1 signaling which are cancer cell proliferation-related gene sets and exhibited an abundance of pro-cancer immune cells. The amount of iLEC correlated inversely with Ki67 expression and histological grade, which is in agreement that low-iLEC breast cancer was associated with enhanced cancer cell proliferation. In conclusion, while iLECs can be used as a surrogate for lymphangiogenesis in breast cancer, low-iLEC tumors also exhibit features which correspond to aggressive tumor biology, which may explain why the amount of iLECs was not associated with patient survival in our cohorts." @default.
• W4225539137 created "2022-05-05" @default.
• W4225539137 creator A5026373258 @default.
• W4225539137 creator A5029088912 @default.
• W4225539137 creator A5031461345 @default.
• W4225539137 creator A5041026823 @default.
• W4225539137 creator A5056811080 @default.
• W4225539137 creator A5057255416 @default.
• W4225539137 creator A5075692104 @default.
• W4225539137 creator A5087348287 @default.
• W4225539137 creator A5090406100 @default.
• W4225539137 date "2022-01-01" @default.
• W4225539137 modified "2023-10-12" @default.
• W4225539137 title "Intratumoral lymphatic endothelial cell infiltration reflecting lymphangiogenesis is counterbalanced by immune responses and better cancer biology in the breast cancer tumor microenvironment." @default.
• W4225539137 cites W176365140 @default.
• W4225539137 cites W1868247522 @default.
• W4225539137 cites W1963948079 @default.
• W4225539137 cites W1973172185 @default.
• W4225539137 cites W1985987855 @default.
• W4225539137 cites W2001253651 @default.
• W4225539137 cites W2001517548 @default.
• W4225539137 cites W2003566453 @default.
• W4225539137 cites W2013317185 @default.
• W4225539137 cites W2032267143 @default.
• W4225539137 cites W2043249221 @default.
• W4225539137 cites W2044702943 @default.
• W4225539137 cites W2050762542 @default.
• W4225539137 cites W2051698951 @default.
• W4225539137 cites W2068881112 @default.
• W4225539137 cites W2071896339 @default.
• W4225539137 cites W2080854536 @default.
• W4225539137 cites W2081174442 @default.
• W4225539137 cites W2096766502 @default.
• W4225539137 cites W2105524916 @default.
• W4225539137 cites W2109597409 @default.
• W4225539137 cites W2115528316 @default.
• W4225539137 cites W2123634971 @default.
• W4225539137 cites W2130410032 @default.
• W4225539137 cites W2135994545 @default.
• W4225539137 cites W2140882198 @default.
• W4225539137 cites W2141932113 @default.
• W4225539137 cites W2144347270 @default.
• W4225539137 cites W2151217876 @default.
• W4225539137 cites W2156323704 @default.
• W4225539137 cites W2199279104 @default.
• W4225539137 cites W2214074259 @default.
• W4225539137 cites W2214816483 @default.
• W4225539137 cites W2365659282 @default.
• W4225539137 cites W2414936097 @default.
• W4225539137 cites W2461271870 @default.
• W4225539137 cites W2486752612 @default.
• W4225539137 cites W2560367415 @default.
• W4225539137 cites W2580335599 @default.
• W4225539137 cites W2587695210 @default.
• W4225539137 cites W2588826493 @default.
• W4225539137 cites W2614206447 @default.
• W4225539137 cites W2729490109 @default.
• W4225539137 cites W2737765537 @default.
• W4225539137 cites W2741684567 @default.
• W4225539137 cites W2748181930 @default.
• W4225539137 cites W2792135005 @default.
• W4225539137 cites W2793775313 @default.
• W4225539137 cites W2796207838 @default.
• W4225539137 cites W2803536643 @default.
• W4225539137 cites W2884260932 @default.
• W4225539137 cites W2891242226 @default.
• W4225539137 cites W2952001873 @default.
• W4225539137 cites W2970704945 @default.
• W4225539137 cites W2985317684 @default.
• W4225539137 cites W3004459445 @default.
• W4225539137 cites W3006851308 @default.
• W4225539137 cites W3014688185 @default.
• W4225539137 cites W3019745072 @default.
• W4225539137 cites W3021996333 @default.
• W4225539137 cites W3023294477 @default.
• W4225539137 cites W3047694317 @default.
• W4225539137 cites W3087379412 @default.
• W4225539137 cites W3088678336 @default.
• W4225539137 cites W3092374644 @default.
• W4225539137 cites W3093268693 @default.
• W4225539137 cites W3107007614 @default.
• W4225539137 cites W3108044685 @default.
• W4225539137 cites W3116246032 @default.
• W4225539137 cites W3123161545 @default.
• W4225539137 cites W3130084903 @default.
• W4225539137 cites W3158205564 @default.
• W4225539137 cites W3164468433 @default.
• W4225539137 cites W3168376845 @default.
• W4225539137 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35261783" @default.
• W4225539137 hasPublicationYear "2022" @default.
• W4225539137 type Work @default.
• W4225539137 citedByCount "7" @default.
• W4225539137 countsByYear W42255391372022 @default.
• W4225539137 countsByYear W42255391372023 @default.
• W4225539137 crossrefType "journal-article" @default.
• W4225539137 hasAuthorship W4225539137A5026373258 @default.
• W4225539137 hasAuthorship W4225539137A5029088912 @default.
• W4225539137 hasAuthorship W4225539137A5031461345 @default.

• next