Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225540255> ?p ?o ?g. }
- W4225540255 abstract "The consequences of systemic inflammation are a significant burden after traumatic brain injury (TBI), with almost all organs affected. This response consists of inflammation and concurrent immunosuppression after injury. One of the main immune regulatory organs, the spleen, is highly interactive with the brain. Along this brain-spleen axis, both nerve fibers as well as brain-derived circulating mediators have been shown to interact directly with splenic immune cells. One of the most significant comorbidities in TBI is acute ethanol intoxication (EI), with almost 40% of patients showing a positive blood alcohol level (BAL) upon injury. EI by itself has been shown to reduce proinflammatory mediators dose-dependently and enhance anti-inflammatory mediators in the spleen. However, how the splenic immune modulatory effect reacts to EI in TBI remains unclear. Therefore, we investigated early splenic immune responses after TBI with and without EI, using gene expression screening of cytokines and chemokines and fluorescence staining of thin spleen sections to investigate cellular mechanisms in immune cells. We found a strong FLT3/FLT3L induction 3 h after TBI, which was enhanced by EI. The FLT3L induction resulted in phosphorylation of FLT3 in CD11c+ dendritic cells, which enhanced protein synthesis, maturation process, and the immunity of dendritic cells, shown by pS6, peIF2A, MHC-II, LAMP1, and CD68 by immunostaining and TNF-α expression by in-situ hybridization. In conclusion, these data indicate that TBI induces a fast maturation and immunity of dendritic cells which is associated with FLT3/FLT3L signaling and which is enhanced by EI prior to TBI." @default.
- W4225540255 created "2022-05-05" @default.
- W4225540255 creator A5000382815 @default.
- W4225540255 creator A5008484351 @default.
- W4225540255 creator A5024003678 @default.
- W4225540255 creator A5047295528 @default.
- W4225540255 creator A5049932951 @default.
- W4225540255 creator A5055174519 @default.
- W4225540255 creator A5067791805 @default.
- W4225540255 creator A5076664249 @default.
- W4225540255 creator A5077327850 @default.
- W4225540255 date "2022-02-24" @default.
- W4225540255 modified "2023-09-30" @default.
- W4225540255 title "Fast Maturation of Splenic Dendritic Cells Upon TBI Is Associated With FLT3/FLT3L Signaling" @default.
- W4225540255 cites W1475794381 @default.
- W4225540255 cites W1486406198 @default.
- W4225540255 cites W1491815146 @default.
- W4225540255 cites W1493704288 @default.
- W4225540255 cites W1503384439 @default.
- W4225540255 cites W1525014857 @default.
- W4225540255 cites W1535379795 @default.
- W4225540255 cites W1586837651 @default.
- W4225540255 cites W1681621819 @default.
- W4225540255 cites W1845309668 @default.
- W4225540255 cites W1909202696 @default.
- W4225540255 cites W1940498497 @default.
- W4225540255 cites W1960895270 @default.
- W4225540255 cites W1963651005 @default.
- W4225540255 cites W1970067942 @default.
- W4225540255 cites W1982890244 @default.
- W4225540255 cites W1984253600 @default.
- W4225540255 cites W1990946292 @default.
- W4225540255 cites W1992466036 @default.
- W4225540255 cites W1997553523 @default.
- W4225540255 cites W1999840739 @default.
- W4225540255 cites W2003593390 @default.
- W4225540255 cites W2011000417 @default.
- W4225540255 cites W2011441755 @default.
- W4225540255 cites W2015895673 @default.
- W4225540255 cites W2016341061 @default.
- W4225540255 cites W2018131256 @default.
- W4225540255 cites W2021235791 @default.
- W4225540255 cites W2028756918 @default.
- W4225540255 cites W2030307261 @default.
- W4225540255 cites W2038624273 @default.
- W4225540255 cites W2043508445 @default.
- W4225540255 cites W2052021788 @default.
- W4225540255 cites W2054828149 @default.
- W4225540255 cites W2059467874 @default.
- W4225540255 cites W2065828939 @default.
- W4225540255 cites W2069067844 @default.
- W4225540255 cites W2069274491 @default.
- W4225540255 cites W2073295417 @default.
- W4225540255 cites W2073444107 @default.
- W4225540255 cites W2075915945 @default.
- W4225540255 cites W2076286830 @default.
- W4225540255 cites W2079279399 @default.
- W4225540255 cites W2081088298 @default.
- W4225540255 cites W2084895348 @default.
- W4225540255 cites W2090685407 @default.
- W4225540255 cites W2093441252 @default.
- W4225540255 cites W2100983368 @default.
- W4225540255 cites W2102689053 @default.
- W4225540255 cites W2103507212 @default.
- W4225540255 cites W2103577428 @default.
- W4225540255 cites W2103906436 @default.
- W4225540255 cites W2107711727 @default.
- W4225540255 cites W2111044557 @default.
- W4225540255 cites W2121990753 @default.
- W4225540255 cites W2123482015 @default.
- W4225540255 cites W2135200515 @default.
- W4225540255 cites W2135498185 @default.
- W4225540255 cites W2147511235 @default.
- W4225540255 cites W2159732692 @default.
- W4225540255 cites W2161357596 @default.
- W4225540255 cites W2168028214 @default.
- W4225540255 cites W2171398137 @default.
- W4225540255 cites W2192493004 @default.
- W4225540255 cites W2196976197 @default.
- W4225540255 cites W2244273880 @default.
- W4225540255 cites W2263355526 @default.
- W4225540255 cites W2270786196 @default.
- W4225540255 cites W2274542647 @default.
- W4225540255 cites W2288962391 @default.
- W4225540255 cites W2335731127 @default.
- W4225540255 cites W2338499223 @default.
- W4225540255 cites W2339030304 @default.
- W4225540255 cites W2339252122 @default.
- W4225540255 cites W2410909896 @default.
- W4225540255 cites W2510960647 @default.
- W4225540255 cites W2540712644 @default.
- W4225540255 cites W2555524932 @default.
- W4225540255 cites W2556505330 @default.
- W4225540255 cites W2619366202 @default.
- W4225540255 cites W2735068577 @default.
- W4225540255 cites W2743343662 @default.
- W4225540255 cites W2744089312 @default.
- W4225540255 cites W2782405999 @default.
- W4225540255 cites W2786556354 @default.
- W4225540255 cites W2790972620 @default.