Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225542609> ?p ?o ?g. }
- W4225542609 abstract "Postoperative surgical adhesions constitute a major health burden internationally. A wide range of materials have been evaluated, but despite constructive efforts and the obvious necessity, there remains no specific barrier widely utilized to prevent postoperative adhesion formation. The aim of this study was to highlight and characterize materials used for prevention of postoperative surgical adhesions in both animal and human studies.A systematic review was performed of all original research articles presenting data related to the prevention of postoperative adhesions using a barrier agent. All available observational studies and randomized trials using animal models or human participants were included, with no restrictions related to type of surgery. PubMed and Embase databases were searched using key terms from inception to August 2019. Standardized data collection forms were used to extract details for each study and assess desirable characteristics of each barrier and success in animal and/or human studies.A total of 185 articles were identified for inclusion in the review, with a total of 67 unique adhesion barrier agents (37 natural and 30 synthetic materials). Desirable barrier characteristics of an ideal barrier were identified on review of the literature. Ten barriers achieved the primary outcome of reducing the incidence of postoperative adhesions in animal studies followed with positive outputs in human participants. A further 48 materials had successful results from animal studies, but with no human study performed to date.Multiple barriers showed promise in animal studies, with several progressing to success, and fulfilment of desirable qualities, in human trials. No barrier is currently utilized commonly worldwide, but potential barriers have been identified to reduce the burden of postoperative adhesions and associated sequelae." @default.
- W4225542609 created "2022-05-05" @default.
- W4225542609 creator A5035073737 @default.
- W4225542609 creator A5042032394 @default.
- W4225542609 creator A5043772057 @default.
- W4225542609 creator A5047214527 @default.
- W4225542609 creator A5059701727 @default.
- W4225542609 date "2022-05-02" @default.
- W4225542609 modified "2023-10-09" @default.
- W4225542609 title "Barrier materials for prevention of surgical adhesions: systematic review" @default.
- W4225542609 cites W1026266142 @default.
- W4225542609 cites W1267059158 @default.
- W4225542609 cites W139486373 @default.
- W4225542609 cites W1611331702 @default.
- W4225542609 cites W1645610384 @default.
- W4225542609 cites W1708501841 @default.
- W4225542609 cites W1822262043 @default.
- W4225542609 cites W1870080799 @default.
- W4225542609 cites W1904964687 @default.
- W4225542609 cites W1964316683 @default.
- W4225542609 cites W1964384389 @default.
- W4225542609 cites W1966835869 @default.
- W4225542609 cites W1967367136 @default.
- W4225542609 cites W1969147363 @default.
- W4225542609 cites W1969150017 @default.
- W4225542609 cites W1971393959 @default.
- W4225542609 cites W1973522661 @default.
- W4225542609 cites W1974644354 @default.
- W4225542609 cites W1976272226 @default.
- W4225542609 cites W1977241855 @default.
- W4225542609 cites W1977305062 @default.
- W4225542609 cites W1977410495 @default.
- W4225542609 cites W1977908753 @default.
- W4225542609 cites W1979958419 @default.
- W4225542609 cites W1979981373 @default.
- W4225542609 cites W1980451238 @default.
- W4225542609 cites W1981116826 @default.
- W4225542609 cites W1984325692 @default.
- W4225542609 cites W1984938291 @default.
- W4225542609 cites W1986512466 @default.
- W4225542609 cites W1988218148 @default.
- W4225542609 cites W1989207199 @default.
- W4225542609 cites W1989636565 @default.
- W4225542609 cites W1990212683 @default.
- W4225542609 cites W1991482971 @default.
- W4225542609 cites W1992048427 @default.
- W4225542609 cites W1995484352 @default.
- W4225542609 cites W1996153731 @default.
- W4225542609 cites W1999209301 @default.
- W4225542609 cites W2001503866 @default.
- W4225542609 cites W2003097201 @default.
- W4225542609 cites W2003810829 @default.
- W4225542609 cites W2004431686 @default.
- W4225542609 cites W2005501262 @default.
- W4225542609 cites W2010294267 @default.
- W4225542609 cites W2010629497 @default.
- W4225542609 cites W2010741457 @default.
- W4225542609 cites W2011194485 @default.
- W4225542609 cites W2011534659 @default.
- W4225542609 cites W2013038342 @default.
- W4225542609 cites W2014760995 @default.
- W4225542609 cites W2015583743 @default.
- W4225542609 cites W2015742088 @default.
- W4225542609 cites W2017957275 @default.
- W4225542609 cites W2018718893 @default.
- W4225542609 cites W2019268293 @default.
- W4225542609 cites W2019464863 @default.
- W4225542609 cites W2021097558 @default.
- W4225542609 cites W2022178173 @default.
- W4225542609 cites W2022538069 @default.
- W4225542609 cites W2028349596 @default.
- W4225542609 cites W2031356847 @default.
- W4225542609 cites W2032888925 @default.
- W4225542609 cites W2033596219 @default.
- W4225542609 cites W2036256516 @default.
- W4225542609 cites W2036919864 @default.
- W4225542609 cites W2037220637 @default.
- W4225542609 cites W2037635285 @default.
- W4225542609 cites W2038562451 @default.
- W4225542609 cites W2039615021 @default.
- W4225542609 cites W2041014238 @default.
- W4225542609 cites W2041927332 @default.
- W4225542609 cites W2044123677 @default.
- W4225542609 cites W2044186819 @default.
- W4225542609 cites W2046744808 @default.
- W4225542609 cites W2049000615 @default.
- W4225542609 cites W2050302398 @default.
- W4225542609 cites W2052078615 @default.
- W4225542609 cites W2054550088 @default.
- W4225542609 cites W2054958642 @default.
- W4225542609 cites W2055877915 @default.
- W4225542609 cites W2058046932 @default.
- W4225542609 cites W2059525578 @default.
- W4225542609 cites W2060435819 @default.
- W4225542609 cites W2060879818 @default.
- W4225542609 cites W2060917851 @default.
- W4225542609 cites W2061058877 @default.
- W4225542609 cites W2062067671 @default.
- W4225542609 cites W2063413057 @default.
- W4225542609 cites W2065224401 @default.