FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225546804> ?p ?o ?g. }

• W4225546804 endingPage "33" @default.
• W4225546804 startingPage "23" @default.
• W4225546804 abstract "Background: Several in vitro and in vivo biological activities of serotonin, 5- hydroxytryptamine (5-HT), as a bioactive molecule, and its transporter (5-HT-Tr) were evaluated in parasitic infections. Objective: Herein, the roles of 5-HT and 5-HTR in helminths and protozoan infections with medical and veterinary importance are reviewed. Methods: We searched information in 4 main databases and reviewed published literature about the serotonin transporter's role as a promising therapeutic target against pathogenic parasitic infections between 2000 and 2021. Results: Based on recent investigations, 5-HT and 5-HT-Tr play various roles in parasite infections, including biological function, metabolic activity, organism motility, parasite survival, and immune response modulation. Moreover, some of the 5-HT-TR in Schistosoma mansoni showed an excess of favorite substrates for biogenic amine 5-HT compared to their mammalian hosts. Furthermore, the main neuronal protein related to the G protein-coupled receptor (GPCR) was identified in S. mansoni and Echinococcus granulosus, playing main roles in these parasites. In addition, 5-HT increased in toxoplasmosis, giardiasis, and Chagas disease. On the other hand, in Plasmodium spp., different forms of targeted 5-HTR stimulate Ca2+ release, intracellular inositol triphosphate (ITP), cAMP, and protein kinase A (PKA) activity. Conclusion: This review summarized the several functional roles of the 5-HT and the importance of the 5-HT-TR as a drug target with minimal harm to the host to fight against helminths and protozoan infections. Hopefully, this review will shed light on research regarding serotonin transporter-based therapies as a potential drug target soon." @default.
• W4225546804 created "2022-05-05" @default.
• W4225546804 creator A5018276982 @default.
• W4225546804 creator A5051945068 @default.
• W4225546804 creator A5088143950 @default.
• W4225546804 date "2022-04-01" @default.
• W4225546804 modified "2023-10-16" @default.
• W4225546804 title "The Potential Role of the Serotonin Transporter as a Drug Target against Parasitic Infections: A Scoping Review of the Literature" @default.
• W4225546804 cites W122233161 @default.
• W4225546804 cites W1548383320 @default.
• W4225546804 cites W1969584011 @default.
• W4225546804 cites W1977188733 @default.
• W4225546804 cites W1977453815 @default.
• W4225546804 cites W1982970232 @default.
• W4225546804 cites W1993725963 @default.
• W4225546804 cites W2004862250 @default.
• W4225546804 cites W2014080590 @default.
• W4225546804 cites W2028772274 @default.
• W4225546804 cites W2041947250 @default.
• W4225546804 cites W2043073154 @default.
• W4225546804 cites W2045076787 @default.
• W4225546804 cites W2045964846 @default.
• W4225546804 cites W2048080607 @default.
• W4225546804 cites W2051692635 @default.
• W4225546804 cites W2069551189 @default.
• W4225546804 cites W2072793236 @default.
• W4225546804 cites W2080460281 @default.
• W4225546804 cites W2085139899 @default.
• W4225546804 cites W2101817799 @default.
• W4225546804 cites W2102003203 @default.
• W4225546804 cites W2108998020 @default.
• W4225546804 cites W2118119469 @default.
• W4225546804 cites W2134073124 @default.
• W4225546804 cites W2135190897 @default.
• W4225546804 cites W2135397024 @default.
• W4225546804 cites W2145529563 @default.
• W4225546804 cites W2151211884 @default.
• W4225546804 cites W2153783740 @default.
• W4225546804 cites W2166022915 @default.
• W4225546804 cites W2177086111 @default.
• W4225546804 cites W2291753626 @default.
• W4225546804 cites W2329242045 @default.
• W4225546804 cites W2396059683 @default.
• W4225546804 cites W2471886669 @default.
• W4225546804 cites W2566370136 @default.
• W4225546804 cites W2581765692 @default.
• W4225546804 cites W2767698477 @default.
• W4225546804 cites W2770931274 @default.
• W4225546804 cites W2785677635 @default.
• W4225546804 cites W2794242475 @default.
• W4225546804 cites W2805207812 @default.
• W4225546804 cites W2884011290 @default.
• W4225546804 cites W2886155772 @default.
• W4225546804 cites W2891582884 @default.
• W4225546804 cites W2894451602 @default.
• W4225546804 cites W2898603746 @default.
• W4225546804 cites W2912653988 @default.
• W4225546804 cites W2926149212 @default.
• W4225546804 cites W2990878713 @default.
• W4225546804 cites W3004234624 @default.
• W4225546804 cites W3033790833 @default.
• W4225546804 cites W3118850673 @default.
• W4225546804 cites W3188937228 @default.
• W4225546804 cites W3195875552 @default.
• W4225546804 cites W4211248987 @default.
• W4225546804 doi "https://doi.org/10.2174/1574891x16666220304232301" @default.
• W4225546804 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35249526" @default.
• W4225546804 hasPublicationYear "2022" @default.
• W4225546804 type Work @default.
• W4225546804 citedByCount "0" @default.
• W4225546804 crossrefType "journal-article" @default.
• W4225546804 hasAuthorship W4225546804A5018276982 @default.
• W4225546804 hasAuthorship W4225546804A5051945068 @default.
• W4225546804 hasAuthorship W4225546804A5088143950 @default.
• W4225546804 hasConcept C104317684 @default.
• W4225546804 hasConcept C149011108 @default.
• W4225546804 hasConcept C170493617 @default.
• W4225546804 hasConcept C203014093 @default.
• W4225546804 hasConcept C2775864247 @default.
• W4225546804 hasConcept C2778897192 @default.
• W4225546804 hasConcept C2780035454 @default.
• W4225546804 hasConcept C37000724 @default.
• W4225546804 hasConcept C55493867 @default.
• W4225546804 hasConcept C86803240 @default.
• W4225546804 hasConcept C8891405 @default.
• W4225546804 hasConcept C89423630 @default.
• W4225546804 hasConcept C98274493 @default.
• W4225546804 hasConceptScore W4225546804C104317684 @default.
• W4225546804 hasConceptScore W4225546804C149011108 @default.
• W4225546804 hasConceptScore W4225546804C170493617 @default.
• W4225546804 hasConceptScore W4225546804C203014093 @default.
• W4225546804 hasConceptScore W4225546804C2775864247 @default.
• W4225546804 hasConceptScore W4225546804C2778897192 @default.
• W4225546804 hasConceptScore W4225546804C2780035454 @default.
• W4225546804 hasConceptScore W4225546804C37000724 @default.
• W4225546804 hasConceptScore W4225546804C55493867 @default.
• W4225546804 hasConceptScore W4225546804C86803240 @default.
• W4225546804 hasConceptScore W4225546804C8891405 @default.

• next