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- W4225549372 abstract "Heart failure is a major public health problem, and abnormal iron metabolism is common in patients with heart failure. Although iron is necessary for metabolic homeostasis, it induces a programmed iron-dependent form of necrosis, ferroptosis. Iron release from ferritin storage is through nuclear receptor coactivator 4 (NCOA4)-mediated autophagic degradation, known as ferritinophagy. However, the role of ferritinophagy and ferroptosis in the stressed heart remains unclear. To examine the role of ferritinophagy in cardiomyocytes, cardiomyocyte-specific NCOA4-deficient mice were generated. The mice were subjected to pressure overload by means of transverse aortic constriction to induce heart failure. Deletion of Ncoa4 in mouse hearts reduced left ventricular chamber size and improved cardiac function along with the attenuation of the upregulation of ferritinophagy-mediated ferritin degradation 4 weeks after pressure overload. Free ferrous iron overload and increased lipid peroxidation were suppressed in NCOA4-deficient hearts. A potent inhibitor of lipid peroxidation, ferrostatin-1, significantly mitigated the development of pressure overload-induced dilated cardiomyopathy in wild-type mice. Thus, the activation of ferritinophagy results in the development of heart failure, whereas inhibition of this process protects the heart against hemodynamic stress." @default.
- W4225549372 created "2022-05-05" @default.
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- W4225549372 date "2022-01-01" @default.
- W4225549372 modified "2023-10-18" @default.
- W4225549372 title "Iron derived from ferritinophagy induces cardiomyocyte death and heart failure in mice" @default.
- W4225549372 doi "https://doi.org/10.1254/jpssuppl.95.0_1-yia-18" @default.
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