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- W4225549376 abstract "AbstractSpreading Depression (SD) is a brain phenomenon that involves intense neuronal activities and, consequently, change the energy metabolism responsible for the production of ATP and lactate. The aim of the present work was to investigate, using mathematical modeling and computational simulations, the behavior of ATP and Lactate production during the SD. The mathematical model used to simulate SD wave describes electrochemical mechanisms from the dentate gyrus of rat hippocampus. In this work, a mathematical description of the reactions involved in energy metabolism responsible for the production of ATP and lactate, in neurons and glia, was also used to perform the simulations. Investigating how neuronal and glial energy metabolisms are able to maintain the level of ATP and lactate, it was possible to described how happens the lactate increase in the neuronal tissue during the SD. Simulations suggest that the lactate produced by glial metabolism is essential for neuronal metabolism to maintain the ATP level during SD.KeywordsLactateSpreading depressionMathematical modelSimulations" @default.
- W4225549376 created "2022-05-05" @default.
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- W4225549376 date "2022-01-01" @default.
- W4225549376 modified "2023-09-26" @default.
- W4225549376 title "Increase of Lactate Concentration During Spreading Depression" @default.
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- W4225549376 doi "https://doi.org/10.1007/978-3-030-70601-2_328" @default.
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