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- W4225553023 abstract "Fosfomycin trometamol (FT) has shown promising in vitro activity against multidrug-resistant (MDR) uropathogens; however, clinical data are limited in pediatric patients. We conducted a retrospective study to describe the clinical and microbiological outcomes of uncomplicated lower urinary tract infections (LUTIs) due to MDR Escherichia coli treated with oral FT in female adolescents. A total of 70 outpatients, with a median age of 13 years (range 12-16 years), were included. FT was initiated as definitive treatment of UTIs in all patients due to documented resistance against alternative oral agents. All patients received a single dose of 3 g oral FT. The post-treatment clinical and microbiological cure rates were 97% (68/70) and 94% (66/70), respectively. Only two (3%) patients reported mild, self-limited diarrhea. UTI relapse occurred in two (3%) patients. Our results suggest that oral FT might be an alternative option for outpatient treatment of uncomplicated LUTIs due to MDR E. coli in female adolescents." @default.
- W4225553023 created "2022-05-05" @default.
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- W4225553023 date "2021-07-21" @default.
- W4225553023 modified "2023-10-17" @default.
- W4225553023 title "Oral fosfomycin for treating lower urinary tract infections due to multidrug-resistant <i>Escherichia coli</i> in female adolescents" @default.
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- W4225553023 doi "https://doi.org/10.1080/1120009x.2021.1955203" @default.
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