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- W4225564636 abstract ": The caspase family is commonly involved in the pathophysiology of acute brain injury (ABI) through complex apoptotic, pyroptotic, and inflammatory pathways. Current translational strategies for caspase modulation in ABI primarily focus on caspase inhibitors. Because there are no caspase-inhibiting drugs approved for clinical use on the market, the development of caspase inhibitors remains an attractive challenge for researchers and clinicians. Therefore, we conducted the present review with the aim of providing a comprehensive introduction of caspases in ABI. In this review, we summarized the available evidence and potential mechanisms regarding the biological function of caspases. We also reviewed the therapeutic effects of caspase inhibitors on ABI and its subsequent complications. However, various important issues remain unclear, prompting further verification of the efficacy and safety regarding clinical application of caspase inhibitors. We believe that our work will be helpful to further understand the critical role of the caspase family and will provide novel therapeutic potential for ABI treatment." @default.
- W4225564636 created "2022-05-05" @default.
- W4225564636 creator A5000212688 @default.
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- W4225564636 date "2022-06-01" @default.
- W4225564636 modified "2023-10-18" @default.
- W4225564636 title "The Role of Caspase Family in Acute Brain Injury: The Potential Therapeutic Targets in the Future" @default.
- W4225564636 cites W126490209 @default.
- W4225564636 cites W14550876 @default.
- W4225564636 cites W1496818047 @default.
- W4225564636 cites W1522782595 @default.
- W4225564636 cites W1528489066 @default.
- W4225564636 cites W1536213364 @default.
- W4225564636 cites W1539741413 @default.
- W4225564636 cites W1541679432 @default.
- W4225564636 cites W1542039550 @default.
- W4225564636 cites W1548169857 @default.
- W4225564636 cites W1570809006 @default.
- W4225564636 cites W1593410425 @default.
- W4225564636 cites W1904500917 @default.
- W4225564636 cites W1936565989 @default.
- W4225564636 cites W1942214720 @default.
- W4225564636 cites W1959223184 @default.
- W4225564636 cites W1966654200 @default.
- W4225564636 cites W1967866252 @default.
- W4225564636 cites W1968112618 @default.
- W4225564636 cites W1970407770 @default.
- W4225564636 cites W1971682015 @default.
- W4225564636 cites W1973348739 @default.
- W4225564636 cites W1974340416 @default.
- W4225564636 cites W1975448513 @default.
- W4225564636 cites W1976150153 @default.
- W4225564636 cites W1979052642 @default.
- W4225564636 cites W1980322143 @default.
- W4225564636 cites W1984028519 @default.
- W4225564636 cites W1984346050 @default.
- W4225564636 cites W1984759940 @default.
- W4225564636 cites W1984767608 @default.
- W4225564636 cites W1988601630 @default.
- W4225564636 cites W1990958589 @default.
- W4225564636 cites W1995757963 @default.
- W4225564636 cites W1997351400 @default.
- W4225564636 cites W1998763437 @default.
- W4225564636 cites W1999322875 @default.
- W4225564636 cites W1999331588 @default.
- W4225564636 cites W2003702237 @default.
- W4225564636 cites W2003855031 @default.
- W4225564636 cites W2005410446 @default.
- W4225564636 cites W2005893249 @default.
- W4225564636 cites W2010832638 @default.
- W4225564636 cites W2012789061 @default.
- W4225564636 cites W2016540525 @default.
- W4225564636 cites W2022647670 @default.
- W4225564636 cites W2030754641 @default.
- W4225564636 cites W2032235027 @default.
- W4225564636 cites W2032802322 @default.
- W4225564636 cites W2033828028 @default.
- W4225564636 cites W2034557611 @default.
- W4225564636 cites W2036162274 @default.
- W4225564636 cites W2039515131 @default.
- W4225564636 cites W2040088974 @default.
- W4225564636 cites W2041978829 @default.
- W4225564636 cites W2043902549 @default.
- W4225564636 cites W2044326611 @default.
- W4225564636 cites W2046802002 @default.
- W4225564636 cites W2058977340 @default.
- W4225564636 cites W2060911909 @default.
- W4225564636 cites W2067656886 @default.
- W4225564636 cites W2069434863 @default.
- W4225564636 cites W2075800579 @default.
- W4225564636 cites W2076916992 @default.
- W4225564636 cites W2077606257 @default.
- W4225564636 cites W2083271570 @default.
- W4225564636 cites W2083954838 @default.
- W4225564636 cites W2084092378 @default.
- W4225564636 cites W2085848065 @default.
- W4225564636 cites W2086188681 @default.
- W4225564636 cites W2094839012 @default.
- W4225564636 cites W2097221730 @default.
- W4225564636 cites W2100871428 @default.
- W4225564636 cites W2101950940 @default.
- W4225564636 cites W2104526708 @default.
- W4225564636 cites W2117733553 @default.
- W4225564636 cites W2121753028 @default.
- W4225564636 cites W2121842388 @default.
- W4225564636 cites W2125403082 @default.
- W4225564636 cites W2127326606 @default.
- W4225564636 cites W2127650233 @default.