FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225565542> ?p ?o ?g. }

• W4225565542 endingPage "700" @default.
• W4225565542 startingPage "685" @default.
• W4225565542 abstract "Chronic obstructive pulmonary disease (COPD) is an inflammatory-related disease highly associated with increased lung cancer risk. Studies have explored the tumor promoting roles for zinc finger protein 143 (ZNF143). However, the role of ZNF143 in COPD and tumor microenvironment of non-small cell lung cancer (NSCLC) has not been fully elucidated.COPD-related key genes were identified by differential gene expression evaluation, WGCNA and SVM-RFE analysis using mRNA expression data retrieved from public databases. ROC analysis was conducted to evaluate the diagnostic value of ZNF143. Correlation between ZNF143 and clinic-pathological features, associations with tumor-infiltrating immune cells (TICs) and the relationship with predictors of immunotherapy efficacy were explored. ZNF143 gene expression was validated by qRT-PCR using an independent cohort.Bioinformatic and machine learning analysis showed that ZNF143 was a COPD-related gene. ZNF143 expression was significantly upregulated in COPD and is a potential diagnostic biomarker in COPD with AUC > 0.85. ZNF143 expression was significantly upregulated in lung squamous cell carcinoma (LUSC) and lung adenocarcinoma (LUAD). ZNF143 expression levels were significantly higher in LUAD patients with COPD relative to the levels in patients only with LUAD. Upregulation of ZNF143 in patients with comorbidity of NSCLC and COPD was further confirmed by qRT-PCR analysis. High expression of ZNF143 was significantly correlated with advanced TNM stage in LUSC. High ZNF143 expression was associated with activated TICs in both LUAD and LUSC samples. Moreover, ZNF143 expression was significantly correlated with the levels of several known predictors of immunotherapy efficacy, including PD-L1, PD-L2, TMB and TIDE in NSCLC.ZNF143 is a novel COPD biomarker. High expression level of ZNF143 is associated with immune microenvironment and high risk of progression of COPD to NSCLC." @default.
• W4225565542 created "2022-05-05" @default.
• W4225565542 creator A5016671452 @default.
• W4225565542 creator A5036423556 @default.
• W4225565542 creator A5048826252 @default.
• W4225565542 creator A5049132248 @default.
• W4225565542 creator A5058328352 @default.
• W4225565542 creator A5069849278 @default.
• W4225565542 creator A5073216396 @default.
• W4225565542 creator A5085460763 @default.
• W4225565542 creator A5085707610 @default.
• W4225565542 date "2022-04-01" @default.
• W4225565542 modified "2023-10-10" @default.
• W4225565542 title "ZNF143 Expression is Associated with COPD and Tumor Microenvironment in Non-Small Cell Lung Cancer" @default.
• W4225565542 cites W1966327575 @default.
• W4225565542 cites W1972248141 @default.
• W4225565542 cites W2060070314 @default.
• W4225565542 cites W2089613496 @default.
• W4225565542 cites W2101411920 @default.
• W4225565542 cites W2104347254 @default.
• W4225565542 cites W2149441684 @default.
• W4225565542 cites W2156353875 @default.
• W4225565542 cites W2169237347 @default.
• W4225565542 cites W2172592858 @default.
• W4225565542 cites W2310005194 @default.
• W4225565542 cites W2342639474 @default.
• W4225565542 cites W2393905053 @default.
• W4225565542 cites W2396236058 @default.
• W4225565542 cites W2471208681 @default.
• W4225565542 cites W2471276740 @default.
• W4225565542 cites W2491690475 @default.
• W4225565542 cites W2559793986 @default.
• W4225565542 cites W2572174216 @default.
• W4225565542 cites W2588339892 @default.
• W4225565542 cites W2594793697 @default.
• W4225565542 cites W2597237488 @default.
• W4225565542 cites W2599766640 @default.
• W4225565542 cites W2606495925 @default.
• W4225565542 cites W2756181170 @default.
• W4225565542 cites W2759987239 @default.
• W4225565542 cites W2781771913 @default.
• W4225565542 cites W2791527925 @default.
• W4225565542 cites W2886498337 @default.
• W4225565542 cites W2890875511 @default.
• W4225565542 cites W2899053328 @default.
• W4225565542 cites W2903814629 @default.
• W4225565542 cites W2966909203 @default.
• W4225565542 cites W2999417355 @default.
• W4225565542 cites W3015218111 @default.
• W4225565542 cites W3027917450 @default.
• W4225565542 cites W3038444305 @default.
• W4225565542 cites W3046458349 @default.
• W4225565542 cites W3096437880 @default.
• W4225565542 cites W3110993626 @default.
• W4225565542 cites W3118617454 @default.
• W4225565542 cites W3121425150 @default.
• W4225565542 cites W3126266552 @default.
• W4225565542 cites W3134900129 @default.
• W4225565542 cites W3135416914 @default.
• W4225565542 cites W3135900276 @default.
• W4225565542 cites W3139275794 @default.
• W4225565542 cites W3205134688 @default.
• W4225565542 doi "https://doi.org/10.2147/copd.s352392" @default.
• W4225565542 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35400998" @default.
• W4225565542 hasPublicationYear "2022" @default.
• W4225565542 type Work @default.
• W4225565542 citedByCount "3" @default.
• W4225565542 countsByYear W42255655422022 @default.
• W4225565542 countsByYear W42255655422023 @default.
• W4225565542 crossrefType "journal-article" @default.
• W4225565542 hasAuthorship W4225565542A5016671452 @default.
• W4225565542 hasAuthorship W4225565542A5036423556 @default.
• W4225565542 hasAuthorship W4225565542A5048826252 @default.
• W4225565542 hasAuthorship W4225565542A5049132248 @default.
• W4225565542 hasAuthorship W4225565542A5058328352 @default.
• W4225565542 hasAuthorship W4225565542A5069849278 @default.
• W4225565542 hasAuthorship W4225565542A5073216396 @default.
• W4225565542 hasAuthorship W4225565542A5085460763 @default.
• W4225565542 hasAuthorship W4225565542A5085707610 @default.
• W4225565542 hasBestOaLocation W42255655421 @default.
• W4225565542 hasConcept C121608353 @default.
• W4225565542 hasConcept C126322002 @default.
• W4225565542 hasConcept C143998085 @default.
• W4225565542 hasConcept C2776107976 @default.
• W4225565542 hasConcept C2776256026 @default.
• W4225565542 hasConcept C2776780178 @default.
• W4225565542 hasConcept C2781182431 @default.
• W4225565542 hasConcept C2781197716 @default.
• W4225565542 hasConcept C55493867 @default.
• W4225565542 hasConcept C71924100 @default.
• W4225565542 hasConcept C86803240 @default.
• W4225565542 hasConceptScore W4225565542C121608353 @default.
• W4225565542 hasConceptScore W4225565542C126322002 @default.
• W4225565542 hasConceptScore W4225565542C143998085 @default.
• W4225565542 hasConceptScore W4225565542C2776107976 @default.
• W4225565542 hasConceptScore W4225565542C2776256026 @default.
• W4225565542 hasConceptScore W4225565542C2776780178 @default.
• W4225565542 hasConceptScore W4225565542C2781182431 @default.

• next