FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225566369> ?p ?o ?g. }

• W4225566369 endingPage "S26" @default.
• W4225566369 startingPage "S26" @default.
• W4225566369 abstract "Abstract BACKGROUND Partial enteral nutritional therapy (PEN, defined as 80% of daily caloric intake from formula) has shown similar efficacy in inducing remission for pediatric Crohn’s Disease (CD) in comparison to exclusive enteral nutrition (EEN, defined as 100% of daily caloric intake from formula). Long-term outcomes of PEN are not well defined in the literature We aimed to study the long-term outcomes of PEN as defined by the number of patients still on maintenance PEN at 1 and 2 years after initiation. METHODS This was a retrospective cohort study using electronic medical record data at a large pediatric academic center. Patients diagnosed with CD between ages 7-19 years at PEN initiation with available follow-up data were included. Exclusion criteria were diagnoses of ulcerative colitis or indeterminate colitis, concomitant treatment with systemic steroids (prednisone (or equivalent) dose &gt; 20 mg daily), biologics, or immunomodulators. Data collected included demographic and IBD characteristics as well as details of PEN therapy. We calculated the one and two-year PEN persistence rates and used Kaplan-Meier methods to produce survival curves of PEN persistence with adjustment for censoring. RESULTS Between 2009 and 2021, forty-nine participants met inclusion criteria (out of 114 assessed for inclusion). Participants were mostly white (n = 38, 77%), and male (n = 30, 61%). The mean age at CD diagnosis was 11.4 years (standard deviation, SD: 2.9 years) and the mean age at PEN initiation was 12.1 years (SD: 2.6 years). The most common reasons for PEN initiation were primary induction (n = 30, 61%), family/patient preference to avoid other medications (n = 26, 53%), and failure of primary medical therapy (n = 10, 20%). The most chosen formula type for PEN therapy was partially hydrolyzed formulas (n = 30, 61%), followed by standard formulas with whole intact proteins (n = 16, 33%). The one-year PEN persistence rate was 51% (26/49) and the two-year persistence rate was 25% (12/49) (table1). The median time on PEN was 1.3 years (IQR: 0.6 – 2.2 years) (Figure 1). The most common reasons for discontinuation were disease relapse/progression (n=32/41,78%) and treatment non-adherence (n =8/41, 20%). A small number of individuals discontinued due to formula intolerance (n = 3/41,7%). The most common medical therapies escalated to were infliximab (n =21/41, 51%), and adalimumab (n = 8/41, 20%) when PEN was discontinued. DISCUSSION Our study suggests that PEN therapy can be used as potential long-term treatment strategy for mild pediatric Crohn’s disease while avoiding corticosteroids and side-effects common with other IBD therapies. Secondary analysis is underway to understand predictors of response or failure to PEN therapy such as disease location/ distribution, type of formula, and the amount of calories from food vs. formula." @default.
• W4225566369 created "2022-05-05" @default.
• W4225566369 creator A5023456831 @default.
• W4225566369 creator A5036799096 @default.
• W4225566369 creator A5044479753 @default.
• W4225566369 creator A5047571911 @default.
• W4225566369 creator A5060021862 @default.
• W4225566369 date "2022-01-22" @default.
• W4225566369 modified "2023-09-30" @default.
• W4225566369 title "LONG TERM OUTCOMES OF PARTIAL ENTERAL NUTRITION THERAPY IN CHILDREN WITH CROHN’S DISEASE" @default.
• W4225566369 doi "https://doi.org/10.1093/ibd/izac015.040" @default.
• W4225566369 hasPublicationYear "2022" @default.
• W4225566369 type Work @default.
• W4225566369 citedByCount "0" @default.
• W4225566369 crossrefType "journal-article" @default.
• W4225566369 hasAuthorship W4225566369A5023456831 @default.
• W4225566369 hasAuthorship W4225566369A5036799096 @default.
• W4225566369 hasAuthorship W4225566369A5044479753 @default.
• W4225566369 hasAuthorship W4225566369A5047571911 @default.
• W4225566369 hasAuthorship W4225566369A5060021862 @default.
• W4225566369 hasBestOaLocation W42255663691 @default.
• W4225566369 hasConcept C10515644 @default.
• W4225566369 hasConcept C126322002 @default.
• W4225566369 hasConcept C167135981 @default.
• W4225566369 hasConcept C187212893 @default.
• W4225566369 hasConcept C195910791 @default.
• W4225566369 hasConcept C2776694085 @default.
• W4225566369 hasConcept C2778283404 @default.
• W4225566369 hasConcept C2778720950 @default.
• W4225566369 hasConcept C2779134260 @default.
• W4225566369 hasConcept C2779280984 @default.
• W4225566369 hasConcept C2779384505 @default.
• W4225566369 hasConcept C44315111 @default.
• W4225566369 hasConcept C71924100 @default.
• W4225566369 hasConcept C72563966 @default.
• W4225566369 hasConcept C78722104 @default.
• W4225566369 hasConceptScore W4225566369C10515644 @default.
• W4225566369 hasConceptScore W4225566369C126322002 @default.
• W4225566369 hasConceptScore W4225566369C167135981 @default.
• W4225566369 hasConceptScore W4225566369C187212893 @default.
• W4225566369 hasConceptScore W4225566369C195910791 @default.
• W4225566369 hasConceptScore W4225566369C2776694085 @default.
• W4225566369 hasConceptScore W4225566369C2778283404 @default.
• W4225566369 hasConceptScore W4225566369C2778720950 @default.
• W4225566369 hasConceptScore W4225566369C2779134260 @default.
• W4225566369 hasConceptScore W4225566369C2779280984 @default.
• W4225566369 hasConceptScore W4225566369C2779384505 @default.
• W4225566369 hasConceptScore W4225566369C44315111 @default.
• W4225566369 hasConceptScore W4225566369C71924100 @default.
• W4225566369 hasConceptScore W4225566369C72563966 @default.
• W4225566369 hasConceptScore W4225566369C78722104 @default.
• W4225566369 hasIssue "Supplement_1" @default.
• W4225566369 hasLocation W42255663691 @default.
• W4225566369 hasOpenAccess W4225566369 @default.
• W4225566369 hasPrimaryLocation W42255663691 @default.
• W4225566369 hasRelatedWork W153643452 @default.
• W4225566369 hasRelatedWork W173232826 @default.
• W4225566369 hasRelatedWork W2030388492 @default.
• W4225566369 hasRelatedWork W2100557404 @default.
• W4225566369 hasRelatedWork W2414964530 @default.
• W4225566369 hasRelatedWork W2612106233 @default.
• W4225566369 hasRelatedWork W2796007103 @default.
• W4225566369 hasRelatedWork W3006581504 @default.
• W4225566369 hasRelatedWork W3159303587 @default.
• W4225566369 hasRelatedWork W4283155250 @default.
• W4225566369 hasVolume "28" @default.
• W4225566369 isParatext "false" @default.
• W4225566369 isRetracted "false" @default.
• W4225566369 workType "article" @default.