FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225568068> ?p ?o ?g. }

• W4225568068 endingPage "2149" @default.
• W4225568068 startingPage "2140" @default.
• W4225568068 abstract "Anxiety disorders are highly prevalent among individuals with a history of prenatal alcohol exposure (PAE), and adolescent rodents demonstrate anxiety-like behavior following moderate PAE on Gestational Day (G) 12. A likely systemic target of PAE is the stress peptide corticotropin-releasing factor (CRF), as activation of CRF receptor 1 (CRFR1) in the medial nucleus of the central amygdala (CeM) is known to increase anxiety-like behavior in adults. To determine if CRF-CRFR1 interactions underly PAE-induced anxiety, functional changes in CRF system activity were investigated in adolescent male and female Sprague Dawley rats following G12 PAE. Compared to air-exposed controls, PAE increased basal spontaneous (s) inhibitory postsynaptic current (IPSC) frequency in the CeM of males, but not females. Furthermore, PAE blunted CRFR1-regulated miniature (m) IPSCs in a sex- and concentration-specific manner, and only PAE males demonstrated tonic CRFR1 activity in the CeM. It was further determined that G12 PAE decreased CRFR1 mRNA in the CeM of males while increasing regional expression in females. Finally, infusion of a CRFR1 agonist into the CeM of adolescents produced a blunted expression of CRFR1-induced anxiety-like behavior exclusively in PAE males, mirroring the blunted physiology demonstrated by PAE males. Cumulatively, these data suggest that CRFR1 function within the CeM is age- and sex-specific, and PAE not only increases the expression of anxiety-like behavior, but may reduce the efficacy of treatment for PAE-induced anxiety through CRFR1-associated mechanisms. Therefore, future research will be necessary to develop targeted treatment of anxiety disorders in individuals with a history of PAE." @default.
• W4225568068 created "2022-05-05" @default.
• W4225568068 creator A5049791269 @default.
• W4225568068 creator A5063420657 @default.
• W4225568068 date "2022-04-27" @default.
• W4225568068 modified "2023-10-15" @default.
• W4225568068 title "Moderate prenatal alcohol exposure modifies sex-specific CRFR1 activity in the central amygdala and anxiety-like behavior in adolescent offspring" @default.
• W4225568068 cites W1848640059 @default.
• W4225568068 cites W1970657660 @default.
• W4225568068 cites W1984109440 @default.
• W4225568068 cites W1985454844 @default.
• W4225568068 cites W1992642926 @default.
• W4225568068 cites W2037249096 @default.
• W4225568068 cites W2049638289 @default.
• W4225568068 cites W2053303406 @default.
• W4225568068 cites W2069946469 @default.
• W4225568068 cites W2076525549 @default.
• W4225568068 cites W2080220128 @default.
• W4225568068 cites W2080318269 @default.
• W4225568068 cites W2082827602 @default.
• W4225568068 cites W2084539827 @default.
• W4225568068 cites W2095127499 @default.
• W4225568068 cites W2099180447 @default.
• W4225568068 cites W2119458248 @default.
• W4225568068 cites W2133944759 @default.
• W4225568068 cites W2143532600 @default.
• W4225568068 cites W2152948116 @default.
• W4225568068 cites W2153404961 @default.
• W4225568068 cites W2153592313 @default.
• W4225568068 cites W2164292837 @default.
• W4225568068 cites W2176169250 @default.
• W4225568068 cites W2233635691 @default.
• W4225568068 cites W2332754519 @default.
• W4225568068 cites W2406588315 @default.
• W4225568068 cites W2508271754 @default.
• W4225568068 cites W2563744755 @default.
• W4225568068 cites W2593254042 @default.
• W4225568068 cites W2598932612 @default.
• W4225568068 cites W2759686120 @default.
• W4225568068 cites W2790021031 @default.
• W4225568068 cites W2794786155 @default.
• W4225568068 cites W2797632989 @default.
• W4225568068 cites W2809809433 @default.
• W4225568068 cites W2885069373 @default.
• W4225568068 cites W2887560233 @default.
• W4225568068 cites W2889351762 @default.
• W4225568068 cites W2915426823 @default.
• W4225568068 cites W2951483376 @default.
• W4225568068 cites W3016165193 @default.
• W4225568068 cites W3122166137 @default.
• W4225568068 cites W3137323555 @default.
• W4225568068 cites W4200151969 @default.
• W4225568068 doi "https://doi.org/10.1038/s41386-022-01327-z" @default.
• W4225568068 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35478009" @default.
• W4225568068 hasPublicationYear "2022" @default.
• W4225568068 type Work @default.
• W4225568068 citedByCount "5" @default.
• W4225568068 countsByYear W42255680682022 @default.
• W4225568068 countsByYear W42255680682023 @default.
• W4225568068 crossrefType "journal-article" @default.
• W4225568068 hasAuthorship W4225568068A5049791269 @default.
• W4225568068 hasAuthorship W4225568068A5063420657 @default.
• W4225568068 hasBestOaLocation W42255680682 @default.
• W4225568068 hasConcept C112672928 @default.
• W4225568068 hasConcept C118552586 @default.
• W4225568068 hasConcept C126322002 @default.
• W4225568068 hasConcept C134018914 @default.
• W4225568068 hasConcept C15744967 @default.
• W4225568068 hasConcept C173586616 @default.
• W4225568068 hasConcept C2779144063 @default.
• W4225568068 hasConcept C2779234561 @default.
• W4225568068 hasConcept C54355233 @default.
• W4225568068 hasConcept C558461103 @default.
• W4225568068 hasConcept C71924100 @default.
• W4225568068 hasConcept C86803240 @default.
• W4225568068 hasConceptScore W4225568068C112672928 @default.
• W4225568068 hasConceptScore W4225568068C118552586 @default.
• W4225568068 hasConceptScore W4225568068C126322002 @default.
• W4225568068 hasConceptScore W4225568068C134018914 @default.
• W4225568068 hasConceptScore W4225568068C15744967 @default.
• W4225568068 hasConceptScore W4225568068C173586616 @default.
• W4225568068 hasConceptScore W4225568068C2779144063 @default.
• W4225568068 hasConceptScore W4225568068C2779234561 @default.
• W4225568068 hasConceptScore W4225568068C54355233 @default.
• W4225568068 hasConceptScore W4225568068C558461103 @default.
• W4225568068 hasConceptScore W4225568068C71924100 @default.
• W4225568068 hasConceptScore W4225568068C86803240 @default.
• W4225568068 hasFunder F4320337330 @default.
• W4225568068 hasIssue "12" @default.
• W4225568068 hasLocation W42255680681 @default.
• W4225568068 hasLocation W42255680682 @default.
• W4225568068 hasLocation W42255680683 @default.
• W4225568068 hasOpenAccess W4225568068 @default.
• W4225568068 hasPrimaryLocation W42255680681 @default.
• W4225568068 hasRelatedWork W1980117820 @default.
• W4225568068 hasRelatedWork W1982821560 @default.
• W4225568068 hasRelatedWork W1996322489 @default.
• W4225568068 hasRelatedWork W2016258313 @default.

• next