FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225568522> ?p ?o ?g. }

• W4225568522 endingPage "824" @default.
• W4225568522 startingPage "812" @default.
• W4225568522 abstract "The application of genetic relationships among individuals, characterized by a genetic relationship matrix (GRM), has far-reaching effects in human genetics. However, the current standard to calculate the GRM treats linked markers as independent and does not explicitly model the underlying genealogical history of the study sample. Here, we propose a coalescent-informed framework, namely the expected GRM (eGRM), to infer the expected relatedness between pairs of individuals given an ancestral recombination graph (ARG) of the sample. Through extensive simulations, we show that the eGRM is an unbiased estimate of latent pairwise genome-wide relatedness and is robust when computed with ARG inferred from incomplete genetic data. As a result, the eGRM better captures the structure of a population than the canonical GRM, even when using the same genetic information. More importantly, our framework allows a principled approach to estimate the eGRM at different time depths of the ARG, thereby revealing the time-varying nature of population structure in a sample. When applied to SNP array genotypes from a population sample from Northern and Eastern Finland, we find that clustering analysis with the eGRM reveals population structure driven by subpopulations that would not be apparent via the canonical GRM and that temporally the population model is consistent with recent divergence and expansion. Taken together, our proposed eGRM provides a robust tree-centric estimate of relatedness with wide application to genetic studies." @default.
• W4225568522 created "2022-05-05" @default.
• W4225568522 creator A5014280142 @default.
• W4225568522 creator A5020348074 @default.
• W4225568522 creator A5029082038 @default.
• W4225568522 date "2022-05-01" @default.
• W4225568522 modified "2023-10-02" @default.
• W4225568522 title "A genealogical estimate of genetic relationships" @default.
• W4225568522 cites W1955610689 @default.
• W4225568522 cites W1964224776 @default.
• W4225568522 cites W1966775465 @default.
• W4225568522 cites W1979900996 @default.
• W4225568522 cites W1980168725 @default.
• W4225568522 cites W1983539381 @default.
• W4225568522 cites W1983764461 @default.
• W4225568522 cites W1992085420 @default.
• W4225568522 cites W1995664705 @default.
• W4225568522 cites W1999172566 @default.
• W4225568522 cites W2004646826 @default.
• W4225568522 cites W2025865441 @default.
• W4225568522 cites W2031781568 @default.
• W4225568522 cites W2062549788 @default.
• W4225568522 cites W2066669827 @default.
• W4225568522 cites W2067715889 @default.
• W4225568522 cites W2079927753 @default.
• W4225568522 cites W2080873675 @default.
• W4225568522 cites W2086021638 @default.
• W4225568522 cites W2088486634 @default.
• W4225568522 cites W2091705028 @default.
• W4225568522 cites W2108169091 @default.
• W4225568522 cites W2113697014 @default.
• W4225568522 cites W2119344723 @default.
• W4225568522 cites W2125300654 @default.
• W4225568522 cites W2133148918 @default.
• W4225568522 cites W2134049753 @default.
• W4225568522 cites W2155496693 @default.
• W4225568522 cites W2157752701 @default.
• W4225568522 cites W2168933019 @default.
• W4225568522 cites W2229599978 @default.
• W4225568522 cites W2544062746 @default.
• W4225568522 cites W2763344981 @default.
• W4225568522 cites W2763810423 @default.
• W4225568522 cites W2888434560 @default.
• W4225568522 cites W2924359406 @default.
• W4225568522 cites W2951585336 @default.
• W4225568522 cites W2951641704 @default.
• W4225568522 cites W2964006510 @default.
• W4225568522 cites W2966176854 @default.
• W4225568522 cites W2970142068 @default.
• W4225568522 cites W2970459958 @default.
• W4225568522 cites W2971662497 @default.
• W4225568522 cites W2972528716 @default.
• W4225568522 cites W3022098085 @default.
• W4225568522 cites W3031413374 @default.
• W4225568522 cites W3098933058 @default.
• W4225568522 cites W3103625006 @default.
• W4225568522 cites W3120004201 @default.
• W4225568522 cites W3120438017 @default.
• W4225568522 cites W3139043797 @default.
• W4225568522 cites W3172849315 @default.
• W4225568522 cites W3173382720 @default.
• W4225568522 cites W3204843784 @default.
• W4225568522 cites W4213436894 @default.
• W4225568522 cites W4226084702 @default.
• W4225568522 doi "https://doi.org/10.1016/j.ajhg.2022.03.016" @default.
• W4225568522 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35417677" @default.
• W4225568522 hasPublicationYear "2022" @default.
• W4225568522 type Work @default.
• W4225568522 citedByCount "6" @default.
• W4225568522 countsByYear W42255685222022 @default.
• W4225568522 countsByYear W42255685222023 @default.
• W4225568522 crossrefType "journal-article" @default.
• W4225568522 hasAuthorship W4225568522A5014280142 @default.
• W4225568522 hasAuthorship W4225568522A5020348074 @default.
• W4225568522 hasAuthorship W4225568522A5029082038 @default.
• W4225568522 hasBestOaLocation W42255685221 @default.
• W4225568522 hasConcept C104317684 @default.
• W4225568522 hasConcept C105795698 @default.
• W4225568522 hasConcept C144024400 @default.
• W4225568522 hasConcept C149923435 @default.
• W4225568522 hasConcept C184898388 @default.
• W4225568522 hasConcept C185592680 @default.
• W4225568522 hasConcept C193252679 @default.
• W4225568522 hasConcept C198531522 @default.
• W4225568522 hasConcept C2554327 @default.
• W4225568522 hasConcept C2908647359 @default.
• W4225568522 hasConcept C33923547 @default.
• W4225568522 hasConcept C43617362 @default.
• W4225568522 hasConcept C54355233 @default.
• W4225568522 hasConcept C78458016 @default.
• W4225568522 hasConcept C85721925 @default.
• W4225568522 hasConcept C86803240 @default.
• W4225568522 hasConceptScore W4225568522C104317684 @default.
• W4225568522 hasConceptScore W4225568522C105795698 @default.
• W4225568522 hasConceptScore W4225568522C144024400 @default.
• W4225568522 hasConceptScore W4225568522C149923435 @default.
• W4225568522 hasConceptScore W4225568522C184898388 @default.
• W4225568522 hasConceptScore W4225568522C185592680 @default.

• next