Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225568583> ?p ?o ?g. }
- W4225568583 abstract "Genomic studies of bacteria have long pointed toward widespread prevalence of small open reading frames (sORFs) encoding for short proteins, <100 amino acids in length. Despite the mounting genomic evidence of their robust expression, relatively little progress has been made in their mass spectrometry-based detection and various blanket statements have been used to explain this observed discrepancy. In this study, we provide a large-scale riboproteogenomics investigation of the challenging nature of proteomic detection of such small proteins as informed by conditional translation data. A panel of physiochemical properties alongside recently developed mass spectrometry detectability metrics was interrogated to provide a comprehensive evidence-based assessment of sORF-encoded polypeptide (SEP) detectability. Moreover, a large-scale proteomics and translatomics compendium of proteins produced by Salmonella Typhimurium (S. Typhimurium), a model human pathogen, across a panel of growth conditions is presented and used in support of our in silico SEP detectability analysis. This integrative approach is used to provide a data-driven census of small proteins expressed by S. Typhimurium across growth phases and infection-relevant conditions. Taken together, our study pinpoints current limitations in proteomics-based detection of novel small proteins currently missing from bacterial genome annotations." @default.
- W4225568583 created "2022-05-05" @default.
- W4225568583 creator A5020555281 @default.
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- W4225568583 creator A5079964045 @default.
- W4225568583 date "2022-01-01" @default.
- W4225568583 modified "2023-09-26" @default.
- W4225568583 title "Hidden in plain sight: challenges in proteomics detection of small ORF-encoded polypeptides" @default.
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- W4225568583 doi "https://doi.org/10.1093/femsml/uqac005" @default.
- W4225568583 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37223358" @default.
- W4225568583 hasPublicationYear "2022" @default.
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