FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225580413> ?p ?o ?g. }

• W4225580413 abstract "Inflammation and oxidative stress are the major leading hypothetical causes of schizophrenia. Unconjugated bilirubin (UCB) is an efficient endogenous plasma antioxidant. Inflammation is closely linked to oxidative stress. The relationship between UCB and inflammatory markers should be paid close attention in schizophrenia acute stage. In this paper, combined UCB and inflammatory markers were evaluated for their capability in predicting schizophrenia in the acute stage to find an easy and effective indicator to identify acute schizophrenia.A total of 6,937 acute schizophrenia patients and 6,404 healthy controls (HCs) were enrolled. UCB and peripheral biomarkers of inflammation derived from complete blood counts (CBC) were investigated in the subjects with acute schizophrenia, and the results were compared with HCs. Simultaneously, Spearman test was employed to assess the correlation between the variables, while logistic regression was adopted to determine the combined equation and receiver operating characteristic curve was used to evaluate the combined value of UCB and peripheral biomarkers of inflammation derived from CBC to predict schizophrenia in the acute stage.The study indicates that white blood cells, neutrophil, monocyte, mean platelet volume (MPV), red cell distribution width (RDW), neutrophil/lymphocyte ratio (NLR), and monocyte/lymphocyte ratio (MLR) have significantly increased in schizophrenia (p < 0.05 for all), while platelet, lymphocyte, and platelet/lymphocyte ratio (PLR) in schizophrenia have significantly decreased (p < 0.05 for all). UCB exhibits negative correlation with MPV significantly (r = 0.121, p < 0.001), and no correlation with neutrophil and monocyte. The correlations between UCB and other peripheral biomarkers of inflammation derived from CBC are very weak. MPV, RDW, NLR, MLR, PLR, and UCB were taken as independent variables for a logistic regression analysis. The model was as follows: Logit (P1)=-6.141+0.827 MPV+5.613 MLR-0.005 PLR-0.346 UBC. The combination demonstrates better effectiveness in predicting schizophrenia in the acute stage (AUC 0.831, 95% CI 0.825 to 0.837).UCB has a protective effect on acute stage of schizophrenia, which is weak and indirect by affecting the proinflammatory processes. Our findings suggest that a combination of MLR, MPV, PLR, and UBC could be used to predict acute stage of schizophrenia." @default.
• W4225580413 created "2022-05-05" @default.
• W4225580413 creator A5003728286 @default.
• W4225580413 creator A5035898128 @default.
• W4225580413 creator A5037014669 @default.
• W4225580413 creator A5041242808 @default.
• W4225580413 creator A5048068113 @default.
• W4225580413 creator A5051608735 @default.
• W4225580413 creator A5056450584 @default.
• W4225580413 creator A5085010886 @default.
• W4225580413 date "2022-04-07" @default.
• W4225580413 modified "2023-10-06" @default.
• W4225580413 title "Relation Between Unconjugated Bilirubin and Peripheral Biomarkers of Inflammation Derived From Complete Blood Counts in Patients With Acute Stage of Schizophrenia" @default.
• W4225580413 cites W1502278269 @default.
• W4225580413 cites W2009658150 @default.
• W4225580413 cites W2017175635 @default.
• W4225580413 cites W2029057166 @default.
• W4225580413 cites W2043470691 @default.
• W4225580413 cites W2051453027 @default.
• W4225580413 cites W2066961008 @default.
• W4225580413 cites W2073078793 @default.
• W4225580413 cites W2074204454 @default.
• W4225580413 cites W2080380084 @default.
• W4225580413 cites W2084932471 @default.
• W4225580413 cites W2089772634 @default.
• W4225580413 cites W2092000328 @default.
• W4225580413 cites W2099487057 @default.
• W4225580413 cites W2119343421 @default.
• W4225580413 cites W2122719023 @default.
• W4225580413 cites W2124866821 @default.
• W4225580413 cites W2129306023 @default.
• W4225580413 cites W2160408631 @default.
• W4225580413 cites W2403101744 @default.
• W4225580413 cites W2508592054 @default.
• W4225580413 cites W2597156470 @default.
• W4225580413 cites W2624404469 @default.
• W4225580413 cites W2769663778 @default.
• W4225580413 cites W2783894827 @default.
• W4225580413 cites W2809279197 @default.
• W4225580413 cites W2888342366 @default.
• W4225580413 cites W2900874796 @default.
• W4225580413 cites W2904619664 @default.
• W4225580413 cites W2918026097 @default.
• W4225580413 cites W2923950848 @default.
• W4225580413 cites W2926208866 @default.
• W4225580413 cites W2936452886 @default.
• W4225580413 cites W2963282460 @default.
• W4225580413 cites W2969651572 @default.
• W4225580413 cites W2983765585 @default.
• W4225580413 cites W2996042558 @default.
• W4225580413 cites W2996191106 @default.
• W4225580413 cites W3007146357 @default.
• W4225580413 cites W3025251616 @default.
• W4225580413 cites W3028631687 @default.
• W4225580413 cites W3084224661 @default.
• W4225580413 cites W3095364288 @default.
• W4225580413 cites W3097869190 @default.
• W4225580413 cites W3141340405 @default.
• W4225580413 cites W4211025465 @default.
• W4225580413 doi "https://doi.org/10.3389/fpsyt.2022.843985" @default.
• W4225580413 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35463529" @default.
• W4225580413 hasPublicationYear "2022" @default.
• W4225580413 type Work @default.
• W4225580413 citedByCount "2" @default.
• W4225580413 countsByYear W42255804132023 @default.
• W4225580413 crossrefType "journal-article" @default.
• W4225580413 hasAuthorship W4225580413A5003728286 @default.
• W4225580413 hasAuthorship W4225580413A5035898128 @default.
• W4225580413 hasAuthorship W4225580413A5037014669 @default.
• W4225580413 hasAuthorship W4225580413A5041242808 @default.
• W4225580413 hasAuthorship W4225580413A5048068113 @default.
• W4225580413 hasAuthorship W4225580413A5051608735 @default.
• W4225580413 hasAuthorship W4225580413A5056450584 @default.
• W4225580413 hasAuthorship W4225580413A5085010886 @default.
• W4225580413 hasBestOaLocation W42255804131 @default.
• W4225580413 hasConcept C118552586 @default.
• W4225580413 hasConcept C126322002 @default.
• W4225580413 hasConcept C190481736 @default.
• W4225580413 hasConcept C203014093 @default.
• W4225580413 hasConcept C2776151105 @default.
• W4225580413 hasConcept C2776412080 @default.
• W4225580413 hasConcept C2776914184 @default.
• W4225580413 hasConcept C2777063308 @default.
• W4225580413 hasConcept C2777761686 @default.
• W4225580413 hasConcept C2778488018 @default.
• W4225580413 hasConcept C2781184567 @default.
• W4225580413 hasConcept C2781195455 @default.
• W4225580413 hasConcept C29730261 @default.
• W4225580413 hasConcept C71924100 @default.
• W4225580413 hasConcept C74133956 @default.
• W4225580413 hasConcept C78529466 @default.
• W4225580413 hasConcept C89560881 @default.
• W4225580413 hasConcept C90924648 @default.
• W4225580413 hasConceptScore W4225580413C118552586 @default.
• W4225580413 hasConceptScore W4225580413C126322002 @default.
• W4225580413 hasConceptScore W4225580413C190481736 @default.
• W4225580413 hasConceptScore W4225580413C203014093 @default.
• W4225580413 hasConceptScore W4225580413C2776151105 @default.
• W4225580413 hasConceptScore W4225580413C2776412080 @default.
• W4225580413 hasConceptScore W4225580413C2776914184 @default.

• next