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- W4225594288 abstract "Abstract The aim of the present study was to formulate a fluconazole cream for the treatment of Candida albicans. The optimized cream formulation was prepared using stearic acid, oleic acid, beeswax and borax. The uniform distribution of the active ingredient fluconazole could be confirmed in all formulated creams. The FC-C-C formulation showed satisfactory spreadability and extrudability. FC-C-C delivered (95.07 ± 15.85)% in only 36 h, and the formulation released the drug by an anomalous diffusion mechanism. The viscosity of FC-C-C was found to be (63.20 ± 0.83) cP. The antifungal study and animal studies confirmed that the prepared formulation is non-irritant and has an enhanced antifungal activity that reduces the side effects of fluconazole. The studies confirm that the prepared formulation may be useful for the treatment of Candida albicans ." @default.
- W4225594288 created "2022-05-05" @default.
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- W4225594288 date "2022-04-05" @default.
- W4225594288 modified "2023-10-13" @default.
- W4225594288 title "Development of cream to enhance the antifungal activity and reduce the side effects of fluconazole for the treatment of <i>Candida albicans</i>" @default.
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- W4225594288 doi "https://doi.org/10.1515/tsd-2022-2422" @default.
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