Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225602530> ?p ?o ?g. }
- W4225602530 abstract "Co-infection with the avian leukosis virus subgroup J (ALV-J) and the reticuloendotheliosis virus (REV) increases mutual viral replication, causing a more serious pathogenic effect by accelerating the progression of neoplasia and extending the tumor spectrum. However, the molecular mechanism underlying the synergistic replication of ALV-J and REV remains unclear.Here, we performed this study to compare the differentially expressed proteins among CEF cells infected with ALV-J, REV or both at the optimal synergistic infection time using TMT-based quantitative proteomics. We identified a total of 719 (292 upregulated and 427 downregulated) and 64 (35 upregulated and 29 downregulated) proteins by comparing co-infecting both viruses with monoinfecting ALV-J and REV, respectively. GO annotation and KEGG pathway analysis showed the differentially expressed proteins participated in virus-vector interaction, biological adhesion and immune response pathways in the synergistic actions of ALV-J and REV at the protein levels. Among the differentially expressed proteins, a large number of integrins were inhibited or increased in the co-infection group. Further, eight integrins, including ITGα1, ITGα3, ITGα5, ITGα6, ITGα8, ITGα9, ITGα11 and ITGβ3, were validated in CEF cells by qRT-PCR or western blot.These findings proved that integrins may be key regulators in the mechanism of synergistic infection of REV and ALV-J, which will provide more insight into the pathogenesis of synergism of REV and ALV-J at protein level." @default.
- W4225602530 created "2022-05-05" @default.
- W4225602530 creator A5001877853 @default.
- W4225602530 creator A5027181301 @default.
- W4225602530 creator A5049459654 @default.
- W4225602530 creator A5049723085 @default.
- W4225602530 creator A5051727848 @default.
- W4225602530 creator A5089865552 @default.
- W4225602530 date "2022-04-04" @default.
- W4225602530 modified "2023-09-26" @default.
- W4225602530 title "TMT-based proteomic analysis reveals integrins involved in the synergistic infection of reticuloendotheliosis virus and avian leukosis virus subgroup J" @default.
- W4225602530 cites W1237762235 @default.
- W4225602530 cites W1570846537 @default.
- W4225602530 cites W1583664005 @default.
- W4225602530 cites W1649385306 @default.
- W4225602530 cites W1831214496 @default.
- W4225602530 cites W1950118853 @default.
- W4225602530 cites W1994064910 @default.
- W4225602530 cites W2018513605 @default.
- W4225602530 cites W2029231027 @default.
- W4225602530 cites W2033873241 @default.
- W4225602530 cites W2036145275 @default.
- W4225602530 cites W2087963453 @default.
- W4225602530 cites W2108713158 @default.
- W4225602530 cites W2115044953 @default.
- W4225602530 cites W2124181702 @default.
- W4225602530 cites W2133464417 @default.
- W4225602530 cites W2147000598 @default.
- W4225602530 cites W2159482845 @default.
- W4225602530 cites W2342085821 @default.
- W4225602530 cites W2347043573 @default.
- W4225602530 cites W2395028992 @default.
- W4225602530 cites W2409768441 @default.
- W4225602530 cites W2415685344 @default.
- W4225602530 cites W2516217055 @default.
- W4225602530 cites W2522612544 @default.
- W4225602530 cites W2582650135 @default.
- W4225602530 cites W2596193757 @default.
- W4225602530 cites W2774276506 @default.
- W4225602530 cites W2807136282 @default.
- W4225602530 cites W2809147071 @default.
- W4225602530 cites W2809894801 @default.
- W4225602530 cites W2867022353 @default.
- W4225602530 cites W2894457946 @default.
- W4225602530 cites W2901407871 @default.
- W4225602530 cites W2910730299 @default.
- W4225602530 cites W2918303722 @default.
- W4225602530 cites W2951737903 @default.
- W4225602530 cites W2969718750 @default.
- W4225602530 cites W3035112974 @default.
- W4225602530 cites W3049211056 @default.
- W4225602530 cites W3096828292 @default.
- W4225602530 cites W3114025560 @default.
- W4225602530 cites W3157275400 @default.
- W4225602530 cites W3196313603 @default.
- W4225602530 cites W4294216483 @default.
- W4225602530 cites W74685249 @default.
- W4225602530 doi "https://doi.org/10.1186/s12917-022-03207-6" @default.
- W4225602530 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35379256" @default.
- W4225602530 hasPublicationYear "2022" @default.
- W4225602530 type Work @default.
- W4225602530 citedByCount "1" @default.
- W4225602530 countsByYear W42256025302022 @default.
- W4225602530 crossrefType "journal-article" @default.
- W4225602530 hasAuthorship W4225602530A5001877853 @default.
- W4225602530 hasAuthorship W4225602530A5027181301 @default.
- W4225602530 hasAuthorship W4225602530A5049459654 @default.
- W4225602530 hasAuthorship W4225602530A5049723085 @default.
- W4225602530 hasAuthorship W4225602530A5051727848 @default.
- W4225602530 hasAuthorship W4225602530A5089865552 @default.
- W4225602530 hasBestOaLocation W42256025301 @default.
- W4225602530 hasConcept C104317684 @default.
- W4225602530 hasConcept C127561419 @default.
- W4225602530 hasConcept C140704245 @default.
- W4225602530 hasConcept C1491633281 @default.
- W4225602530 hasConcept C150194340 @default.
- W4225602530 hasConcept C152724338 @default.
- W4225602530 hasConcept C159047783 @default.
- W4225602530 hasConcept C162317418 @default.
- W4225602530 hasConcept C195687474 @default.
- W4225602530 hasConcept C2522874641 @default.
- W4225602530 hasConcept C2776415932 @default.
- W4225602530 hasConcept C2777633396 @default.
- W4225602530 hasConcept C46111723 @default.
- W4225602530 hasConcept C502942594 @default.
- W4225602530 hasConcept C54355233 @default.
- W4225602530 hasConcept C86803240 @default.
- W4225602530 hasConceptScore W4225602530C104317684 @default.
- W4225602530 hasConceptScore W4225602530C127561419 @default.
- W4225602530 hasConceptScore W4225602530C140704245 @default.
- W4225602530 hasConceptScore W4225602530C1491633281 @default.
- W4225602530 hasConceptScore W4225602530C150194340 @default.
- W4225602530 hasConceptScore W4225602530C152724338 @default.
- W4225602530 hasConceptScore W4225602530C159047783 @default.
- W4225602530 hasConceptScore W4225602530C162317418 @default.
- W4225602530 hasConceptScore W4225602530C195687474 @default.
- W4225602530 hasConceptScore W4225602530C2522874641 @default.
- W4225602530 hasConceptScore W4225602530C2776415932 @default.
- W4225602530 hasConceptScore W4225602530C2777633396 @default.
- W4225602530 hasConceptScore W4225602530C46111723 @default.