Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225622419> ?p ?o ?g. }
- W4225622419 abstract "Research efforts to combat antimalarial drug resistance rely on quick, robust, and sensitive methods to genetically characterize Plasmodium falciparum parasites. We developed a single-nucleotide polymorphism (SNP)-based genotyping method that can assess 33 drug resistance-conferring SNPs in dhfr, dhps, pfmdr1, pfcrt, and k13 in nine PCRs, performed directly from P. falciparum cultures or infected blood. We also optimized multiplexed fragment analysis and gel electrophoresis-based microsatellite typing methods using a set of five markers that can distinguish 12 laboratory strains of diverse geographical and temporal origin. We demonstrate how these methods can be applied to screen for the multidrug-resistant KEL1/PLA1/PfPailin (KelPP) lineage that has been sweeping across the Greater Mekong Subregion, verify parasite in vitro SNP-editing, identify novel recombinant genetic cross progeny, or cluster strains to infer their geographical origins. Results were compared with Illumina-based whole-genome sequence analysis that provides the most detailed sequence information but is cost-prohibitive. These adaptable, simple, and inexpensive methods can be easily implemented into routine genotyping of P. falciparum parasites in both laboratory and field settings." @default.
- W4225622419 created "2022-05-05" @default.
- W4225622419 creator A5004057964 @default.
- W4225622419 creator A5008928099 @default.
- W4225622419 creator A5038988231 @default.
- W4225622419 creator A5044913327 @default.
- W4225622419 creator A5071314941 @default.
- W4225622419 creator A5077631479 @default.
- W4225622419 date "2022-01-18" @default.
- W4225622419 modified "2023-10-17" @default.
- W4225622419 title "Comparative Analysis of Plasmodium falciparum Genotyping via SNP Detection, Microsatellite Profiling, and Whole-Genome Sequencing" @default.
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