Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225647521> ?p ?o ?g. }
- W4225647521 abstract "The formations of correct three-dimensional structures of proteins are essential to their functions. Cotranslational folding is vital for proteins to form correct structures in vivo. Although some experiments have shown that cotranslational folding can improve the efficiency of folding, its microscopic mechanism is not yet clear. Previously, we built a model of the ribosomal exit tunnel and investigated the cotranslational folding of a three-helix protein by using all-atom molecular dynamics simulations. Here we study the cotranslational folding of three β-sheet-enriched proteins using the same method. The results show that cotranslational folding can enhance the helical population in most cases and reduce non-native long-range contacts before emerging from the ribosomal exit tunnel. After exiting the tunnel, all proteins fall into local minimal states and the structural ensembles of cotranslational folding show more helical conformations than those of free folding. In particular, for one of the three proteins, the GTT WW domain, we find that one local minimum state of the cotranslational folding is the known folding intermediate, which is not found in free folding. This result suggests that the cotranslational folding may increase the folding efficiency by accelerating the sampling more than by avoiding the misfolded state, which is presently a mainstream viewpoint." @default.
- W4225647521 created "2022-05-05" @default.
- W4225647521 creator A5081344481 @default.
- W4225647521 creator A5088434807 @default.
- W4225647521 date "2022-02-03" @default.
- W4225647521 modified "2023-10-17" @default.
- W4225647521 title "Role of cotranslational folding for β-sheet-enriched proteins: A perspective from molecular dynamics simulations" @default.
- W4225647521 cites W1504552716 @default.
- W4225647521 cites W1910438362 @default.
- W4225647521 cites W1965352738 @default.
- W4225647521 cites W1973702310 @default.
- W4225647521 cites W1974333371 @default.
- W4225647521 cites W1975304761 @default.
- W4225647521 cites W1988092390 @default.
- W4225647521 cites W2004822259 @default.
- W4225647521 cites W2008708467 @default.
- W4225647521 cites W2022614391 @default.
- W4225647521 cites W2026076714 @default.
- W4225647521 cites W2026101733 @default.
- W4225647521 cites W2026814176 @default.
- W4225647521 cites W2029667189 @default.
- W4225647521 cites W2032807934 @default.
- W4225647521 cites W2035266068 @default.
- W4225647521 cites W2039911942 @default.
- W4225647521 cites W2041811349 @default.
- W4225647521 cites W2049695588 @default.
- W4225647521 cites W2062110094 @default.
- W4225647521 cites W2065248572 @default.
- W4225647521 cites W2067236515 @default.
- W4225647521 cites W2070360313 @default.
- W4225647521 cites W2070885633 @default.
- W4225647521 cites W2082312460 @default.
- W4225647521 cites W2085717111 @default.
- W4225647521 cites W2086402782 @default.
- W4225647521 cites W2092035637 @default.
- W4225647521 cites W2098354564 @default.
- W4225647521 cites W2102524306 @default.
- W4225647521 cites W2103325328 @default.
- W4225647521 cites W2118233996 @default.
- W4225647521 cites W2125865850 @default.
- W4225647521 cites W2149505288 @default.
- W4225647521 cites W2163915395 @default.
- W4225647521 cites W2163951588 @default.
- W4225647521 cites W2184623063 @default.
- W4225647521 cites W2257602426 @default.
- W4225647521 cites W2313116527 @default.
- W4225647521 cites W2316113687 @default.
- W4225647521 cites W2323537917 @default.
- W4225647521 cites W2332712348 @default.
- W4225647521 cites W2345349091 @default.
- W4225647521 cites W2400939208 @default.
- W4225647521 cites W2404280981 @default.
- W4225647521 cites W2433535207 @default.
- W4225647521 cites W2560234147 @default.
- W4225647521 cites W2582755844 @default.
- W4225647521 cites W2620912806 @default.
- W4225647521 cites W2788861451 @default.
- W4225647521 cites W2790462587 @default.
- W4225647521 cites W2797146534 @default.
- W4225647521 cites W2805624672 @default.
- W4225647521 cites W2808042005 @default.
- W4225647521 cites W2834127074 @default.
- W4225647521 cites W2883873487 @default.
- W4225647521 cites W2899110998 @default.
- W4225647521 cites W2902670890 @default.
- W4225647521 cites W2905515294 @default.
- W4225647521 cites W2950067174 @default.
- W4225647521 cites W2950609213 @default.
- W4225647521 cites W2951806599 @default.
- W4225647521 cites W2960982755 @default.
- W4225647521 cites W2965081535 @default.
- W4225647521 cites W3024325870 @default.
- W4225647521 cites W3037017537 @default.
- W4225647521 cites W3124703980 @default.
- W4225647521 doi "https://doi.org/10.1103/physreve.105.024402" @default.
- W4225647521 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35291071" @default.
- W4225647521 hasPublicationYear "2022" @default.
- W4225647521 type Work @default.
- W4225647521 citedByCount "3" @default.
- W4225647521 countsByYear W42256475212022 @default.
- W4225647521 countsByYear W42256475212023 @default.
- W4225647521 crossrefType "journal-article" @default.
- W4225647521 hasAuthorship W4225647521A5081344481 @default.
- W4225647521 hasAuthorship W4225647521A5088434807 @default.
- W4225647521 hasConcept C119599485 @default.
- W4225647521 hasConcept C12554922 @default.
- W4225647521 hasConcept C127413603 @default.
- W4225647521 hasConcept C147597530 @default.
- W4225647521 hasConcept C162203774 @default.
- W4225647521 hasConcept C185592680 @default.
- W4225647521 hasConcept C19472624 @default.
- W4225647521 hasConcept C204328495 @default.
- W4225647521 hasConcept C2776545253 @default.
- W4225647521 hasConcept C46449900 @default.
- W4225647521 hasConcept C55493867 @default.
- W4225647521 hasConcept C59593255 @default.
- W4225647521 hasConcept C8010536 @default.
- W4225647521 hasConcept C86803240 @default.
- W4225647521 hasConceptScore W4225647521C119599485 @default.
- W4225647521 hasConceptScore W4225647521C12554922 @default.