Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225647574> ?p ?o ?g. }
- W4225647574 abstract "During Drosophila embryogenesis, the essential pioneer factor Zelda defines hundreds of cis-regulatory regions and in doing so reprograms the zygotic transcriptome. While Zelda is essential later in development, it is unclear how the ability of Zelda to define cis-regulatory regions is shaped by cell-type-specific chromatin architecture. Asymmetric division of neural stem cells (neuroblasts) in the fly brain provide an excellent paradigm for investigating the cell-type-specific functions of this pioneer factor. We show that Zelda synergistically functions with Notch to maintain neuroblasts in an undifferentiated state. Zelda misexpression reprograms progenitor cells to neuroblasts, but this capacity is limited by transcriptional repressors critical for progenitor commitment. Zelda genomic occupancy in neuroblasts is reorganized as compared to the embryo, and this reorganization is correlated with differences in chromatin accessibility and cofactor availability. We propose that Zelda regulates essential transitions in the neuroblasts and embryo through a shared gene-regulatory network driven by cell-type-specific enhancers." @default.
- W4225647574 created "2022-05-05" @default.
- W4225647574 creator A5010048030 @default.
- W4225647574 creator A5022969344 @default.
- W4225647574 creator A5034623422 @default.
- W4225647574 creator A5040631498 @default.
- W4225647574 creator A5049621420 @default.
- W4225647574 creator A5053548185 @default.
- W4225647574 creator A5084597012 @default.
- W4225647574 creator A5085051587 @default.
- W4225647574 date "2021-12-09" @default.
- W4225647574 modified "2023-10-10" @default.
- W4225647574 title "Cell-type-specific chromatin occupancy by the pioneer factor Zelda drives key developmental transitions in Drosophila" @default.
- W4225647574 cites W1734170005 @default.
- W4225647574 cites W1818806520 @default.
- W4225647574 cites W1963527872 @default.
- W4225647574 cites W1968065062 @default.
- W4225647574 cites W1971451591 @default.
- W4225647574 cites W1974908487 @default.
- W4225647574 cites W1979513200 @default.
- W4225647574 cites W1981336776 @default.
- W4225647574 cites W1984801642 @default.
- W4225647574 cites W1989618744 @default.
- W4225647574 cites W1991354119 @default.
- W4225647574 cites W2002262418 @default.
- W4225647574 cites W2002602524 @default.
- W4225647574 cites W2004533772 @default.
- W4225647574 cites W2014677321 @default.
- W4225647574 cites W2021892293 @default.
- W4225647574 cites W2022050896 @default.
- W4225647574 cites W2026556066 @default.
- W4225647574 cites W2026998481 @default.
- W4225647574 cites W2027354106 @default.
- W4225647574 cites W2029492292 @default.
- W4225647574 cites W2034466289 @default.
- W4225647574 cites W2040994502 @default.
- W4225647574 cites W2044830131 @default.
- W4225647574 cites W2046769573 @default.
- W4225647574 cites W2054220127 @default.
- W4225647574 cites W2056445079 @default.
- W4225647574 cites W2065387800 @default.
- W4225647574 cites W2065571115 @default.
- W4225647574 cites W2073612080 @default.
- W4225647574 cites W2073759231 @default.
- W4225647574 cites W2073761355 @default.
- W4225647574 cites W2081357269 @default.
- W4225647574 cites W2082867955 @default.
- W4225647574 cites W2088170594 @default.
- W4225647574 cites W2097175728 @default.
- W4225647574 cites W2097353028 @default.
- W4225647574 cites W2098313605 @default.
- W4225647574 cites W2100581810 @default.
- W4225647574 cites W2102619694 @default.
- W4225647574 cites W2102663142 @default.
- W4225647574 cites W2107227145 @default.
- W4225647574 cites W2108234281 @default.
- W4225647574 cites W2110905563 @default.
- W4225647574 cites W2112137379 @default.
- W4225647574 cites W2117757143 @default.
- W4225647574 cites W2117977423 @default.
- W4225647574 cites W2122097157 @default.
- W4225647574 cites W2124296544 @default.
- W4225647574 cites W2126958666 @default.
- W4225647574 cites W2128016314 @default.
- W4225647574 cites W2129422654 @default.
- W4225647574 cites W2129785061 @default.
- W4225647574 cites W2131271579 @default.
- W4225647574 cites W2137654905 @default.
- W4225647574 cites W2142553004 @default.
- W4225647574 cites W2144091055 @default.
- W4225647574 cites W2148120557 @default.
- W4225647574 cites W2154262793 @default.
- W4225647574 cites W2160680240 @default.
- W4225647574 cites W2166037178 @default.
- W4225647574 cites W2170551349 @default.
- W4225647574 cites W2170664141 @default.
- W4225647574 cites W2171675401 @default.
- W4225647574 cites W2171808845 @default.
- W4225647574 cites W2179438025 @default.
- W4225647574 cites W2281392042 @default.
- W4225647574 cites W2288694327 @default.
- W4225647574 cites W2314176140 @default.
- W4225647574 cites W2315765031 @default.
- W4225647574 cites W2336566078 @default.
- W4225647574 cites W2341539131 @default.
- W4225647574 cites W2409052598 @default.
- W4225647574 cites W2411397641 @default.
- W4225647574 cites W2416629879 @default.
- W4225647574 cites W2462979104 @default.
- W4225647574 cites W2549864964 @default.
- W4225647574 cites W2557087167 @default.
- W4225647574 cites W2567402724 @default.
- W4225647574 cites W2573731673 @default.
- W4225647574 cites W2588030177 @default.
- W4225647574 cites W2594706714 @default.
- W4225647574 cites W2611346822 @default.
- W4225647574 cites W2611929604 @default.
- W4225647574 cites W2771292125 @default.
- W4225647574 cites W2783335334 @default.
- W4225647574 cites W2785791409 @default.