Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225647583> ?p ?o ?g. }
- W4225647583 endingPage "e0265256" @default.
- W4225647583 startingPage "e0265256" @default.
- W4225647583 abstract "Neurodegenerative diseases, such as Parkinson's disease, are heterogeneous disorders with a multifactorial nature involving impaired bioenergetics. Stem-regenerative medicine and bioenergetics have been proposed as promising therapeutic targets in the neurologic field. The rationale of the present study was to assess the potential of human-derived adipose stem cells (hASCs) to transdifferentiate into neuronal-like cells (NhASCs and neurospheres) and explore the hASC bioenergetic profile. hASC neuronal transdifferentiation was performed through neurobasal media and differentiation factor exposure. High resolution respirometry was assessed. Increased MAP-2 neuronal marker protein expression upon neuronal induction (p<0.05 undifferentiated hASCs vs. 28-36 days of differentiation) and increased bIII-tubulin neuronal marker protein expression upon neuronal induction (p<0.05 undifferentiated hASCs vs. 6-28-36 days of differentiation) were found. The bioenergetic profile was detectable through high-resolution respirometry approaches in hASCs but did not lead to differential oxidative capacity rates in healthy or clinically diagnosed PD-hASCs. We confirmed the capability of transdifferentiation to the neuronal-like profile of hASCs derived from the forearms of human subjects and characterized the bioenergetic profile. Suboptimal maximal respiratory capacity trends in PD were found. Neuronal induction leading to positive neuronal protein expression markers is a relevant issue that encourages the suitability of NhASC models in neurodegeneration." @default.
- W4225647583 created "2022-05-05" @default.
- W4225647583 creator A5013356684 @default.
- W4225647583 creator A5017650280 @default.
- W4225647583 creator A5025718532 @default.
- W4225647583 creator A5031061515 @default.
- W4225647583 creator A5034781983 @default.
- W4225647583 creator A5039879107 @default.
- W4225647583 creator A5053821673 @default.
- W4225647583 creator A5077658775 @default.
- W4225647583 creator A5078491678 @default.
- W4225647583 creator A5080998360 @default.
- W4225647583 creator A5086187645 @default.
- W4225647583 creator A5077451032 @default.
- W4225647583 date "2022-03-15" @default.
- W4225647583 modified "2023-10-18" @default.
- W4225647583 title "Neuronal induction and bioenergetics characterization of human forearm adipose stem cells from Parkinson’s disease patients and healthy controls" @default.
- W4225647583 cites W1498174432 @default.
- W4225647583 cites W191921287 @default.
- W4225647583 cites W1970865563 @default.
- W4225647583 cites W1978894995 @default.
- W4225647583 cites W1980267283 @default.
- W4225647583 cites W1999436412 @default.
- W4225647583 cites W2005848913 @default.
- W4225647583 cites W2020670112 @default.
- W4225647583 cites W2026535137 @default.
- W4225647583 cites W2029025070 @default.
- W4225647583 cites W2049908093 @default.
- W4225647583 cites W2078145840 @default.
- W4225647583 cites W2087277712 @default.
- W4225647583 cites W2094635970 @default.
- W4225647583 cites W2107503723 @default.
- W4225647583 cites W2115062578 @default.
- W4225647583 cites W2578095037 @default.
- W4225647583 cites W2588436274 @default.
- W4225647583 cites W2793997925 @default.
- W4225647583 cites W2805331197 @default.
- W4225647583 cites W2904266952 @default.
- W4225647583 cites W2943137279 @default.
- W4225647583 cites W2943329679 @default.
- W4225647583 cites W2948225712 @default.
- W4225647583 cites W295334069 @default.
- W4225647583 cites W2990195010 @default.
- W4225647583 cites W2992936365 @default.
- W4225647583 cites W3029713241 @default.
- W4225647583 cites W3120554217 @default.
- W4225647583 cites W3124704489 @default.
- W4225647583 cites W3142030308 @default.
- W4225647583 cites W3157412789 @default.
- W4225647583 cites W3157644511 @default.
- W4225647583 cites W3168037248 @default.
- W4225647583 cites W403995496 @default.
- W4225647583 doi "https://doi.org/10.1371/journal.pone.0265256" @default.
- W4225647583 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35290400" @default.
- W4225647583 hasPublicationYear "2022" @default.
- W4225647583 type Work @default.
- W4225647583 citedByCount "0" @default.
- W4225647583 crossrefType "journal-article" @default.
- W4225647583 hasAuthorship W4225647583A5013356684 @default.
- W4225647583 hasAuthorship W4225647583A5017650280 @default.
- W4225647583 hasAuthorship W4225647583A5025718532 @default.
- W4225647583 hasAuthorship W4225647583A5031061515 @default.
- W4225647583 hasAuthorship W4225647583A5034781983 @default.
- W4225647583 hasAuthorship W4225647583A5039879107 @default.
- W4225647583 hasAuthorship W4225647583A5053821673 @default.
- W4225647583 hasAuthorship W4225647583A5077451032 @default.
- W4225647583 hasAuthorship W4225647583A5077658775 @default.
- W4225647583 hasAuthorship W4225647583A5078491678 @default.
- W4225647583 hasAuthorship W4225647583A5080998360 @default.
- W4225647583 hasAuthorship W4225647583A5086187645 @default.
- W4225647583 hasBestOaLocation W42256475831 @default.
- W4225647583 hasConcept C100206155 @default.
- W4225647583 hasConcept C126322002 @default.
- W4225647583 hasConcept C169760540 @default.
- W4225647583 hasConcept C2776925932 @default.
- W4225647583 hasConcept C2779134260 @default.
- W4225647583 hasConcept C2779734285 @default.
- W4225647583 hasConcept C28328180 @default.
- W4225647583 hasConcept C28859421 @default.
- W4225647583 hasConcept C4746552 @default.
- W4225647583 hasConcept C60870556 @default.
- W4225647583 hasConcept C71924100 @default.
- W4225647583 hasConcept C86803240 @default.
- W4225647583 hasConcept C95444343 @default.
- W4225647583 hasConceptScore W4225647583C100206155 @default.
- W4225647583 hasConceptScore W4225647583C126322002 @default.
- W4225647583 hasConceptScore W4225647583C169760540 @default.
- W4225647583 hasConceptScore W4225647583C2776925932 @default.
- W4225647583 hasConceptScore W4225647583C2779134260 @default.
- W4225647583 hasConceptScore W4225647583C2779734285 @default.
- W4225647583 hasConceptScore W4225647583C28328180 @default.
- W4225647583 hasConceptScore W4225647583C28859421 @default.
- W4225647583 hasConceptScore W4225647583C4746552 @default.
- W4225647583 hasConceptScore W4225647583C60870556 @default.
- W4225647583 hasConceptScore W4225647583C71924100 @default.
- W4225647583 hasConceptScore W4225647583C86803240 @default.
- W4225647583 hasConceptScore W4225647583C95444343 @default.
- W4225647583 hasFunder F4320310210 @default.