FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225650796> ?p ?o ?g. }

• W4225650796 abstract "Abstract Human Infection Studies (HIS) have emerged as an important research approach with the potential to fast track the global development of vaccines and treatments for infectious diseases, including in low resource settings. Given the high level of burdens involved in many HIS, particularly prolonged residency and biological sampling requirements, it can be challenging to identify levels of study payments that provide adequate compensation but avoid ‘undue’ levels of inducement to participate. Through this embedded ethics study, involving 97 healthy volunteers and other research stakeholders in a malaria HIS programme in Kenya, and using in-depth interviews, focus group discussions and observations during and after a malaria HIS, we give a grounded account of ethical issues emerging in relation to study payments in this setting. While careful community, national, international scientific and ethics review processes meant that risks of serious harm were highly unlikely, the levels of motivation to join HIS seen could raise concerns about study payments being too high. Particular value was placed on the reliability, rather than level, of study payment in this setting, where subsistence livelihoods are common. Study volunteers were generally clear about the study aims at the point of recruitment, and this knowledge was retained over a year later, although most reported experiencing more burdens than anticipated at enrolment. Strict study screening procedures, regular clinical and laboratory monitoring of volunteers, with prompt treatment with antimalarial at predetermined endpoints suggested that the risks of serious harm were highly unlikely. Ethical concerns emerged in relation to volunteers’ attempts to conceal symptoms, hoping to prolong residency periods and increase study payments; and volunteers making decisions that compromised important family relationships and personal values. Our findings support an interpretation that, although study volunteers were keen to join the study to access cash payments, they also paid attention to other features of the study and the general clinical research landscape, including levels of risk associated with study participation. Overall, our analysis shows that the ethical concerns emerging from the study payments can be addressed through practical measures, hinged on reducing burdens and strengthening communication, raising important issues for research policy and planning." @default.
• W4225650796 created "2022-05-05" @default.
• W4225650796 creator A5009075899 @default.
• W4225650796 creator A5011091618 @default.
• W4225650796 creator A5039570583 @default.
• W4225650796 creator A5047631647 @default.
• W4225650796 creator A5057821484 @default.
• W4225650796 creator A5084346395 @default.
• W4225650796 creator A5091752515 @default.
• W4225650796 date "2022-04-20" @default.
• W4225650796 modified "2023-10-09" @default.
• W4225650796 title "Ethical considerations around volunteer payments in a malaria human infection study in Kenya: an embedded empirical ethics study" @default.
• W4225650796 cites W1483728677 @default.
• W4225650796 cites W1593345018 @default.
• W4225650796 cites W1751385169 @default.
• W4225650796 cites W1885409381 @default.
• W4225650796 cites W1899236894 @default.
• W4225650796 cites W1973031667 @default.
• W4225650796 cites W1976770755 @default.
• W4225650796 cites W1983192941 @default.
• W4225650796 cites W1994258624 @default.
• W4225650796 cites W2002888583 @default.
• W4225650796 cites W2047321261 @default.
• W4225650796 cites W2066453852 @default.
• W4225650796 cites W2072768480 @default.
• W4225650796 cites W2076422447 @default.
• W4225650796 cites W2086372410 @default.
• W4225650796 cites W2117553507 @default.
• W4225650796 cites W2119678836 @default.
• W4225650796 cites W2123114485 @default.
• W4225650796 cites W2137275956 @default.
• W4225650796 cites W2137999875 @default.
• W4225650796 cites W2151557978 @default.
• W4225650796 cites W2160466152 @default.
• W4225650796 cites W2160708061 @default.
• W4225650796 cites W2165845288 @default.
• W4225650796 cites W2213819824 @default.
• W4225650796 cites W2463878667 @default.
• W4225650796 cites W2600564521 @default.
• W4225650796 cites W2746829895 @default.
• W4225650796 cites W2767216810 @default.
• W4225650796 cites W2777088297 @default.
• W4225650796 cites W2797982574 @default.
• W4225650796 cites W2884414588 @default.
• W4225650796 cites W2888249886 @default.
• W4225650796 cites W2897694664 @default.
• W4225650796 cites W2901431198 @default.
• W4225650796 cites W2902002127 @default.
• W4225650796 cites W2906302237 @default.
• W4225650796 cites W2913046851 @default.
• W4225650796 cites W2944323804 @default.
• W4225650796 cites W2980537309 @default.
• W4225650796 cites W3012771818 @default.
• W4225650796 cites W3026524644 @default.
• W4225650796 cites W3039832990 @default.
• W4225650796 cites W3040737374 @default.
• W4225650796 cites W3045013662 @default.
• W4225650796 cites W3048737734 @default.
• W4225650796 cites W3096851696 @default.
• W4225650796 cites W3103371089 @default.
• W4225650796 cites W3128532561 @default.
• W4225650796 cites W3129661736 @default.
• W4225650796 cites W3131686248 @default.
• W4225650796 cites W3131898973 @default.
• W4225650796 cites W3152986440 @default.
• W4225650796 cites W3155031444 @default.
• W4225650796 cites W3163346164 @default.
• W4225650796 cites W409600501 @default.
• W4225650796 cites W4294738730 @default.
• W4225650796 cites W4322701288 @default.
• W4225650796 doi "https://doi.org/10.1186/s12910-022-00783-y" @default.
• W4225650796 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35443642" @default.
• W4225650796 hasPublicationYear "2022" @default.
• W4225650796 type Work @default.
• W4225650796 citedByCount "1" @default.
• W4225650796 countsByYear W42256507962022 @default.
• W4225650796 crossrefType "journal-article" @default.
• W4225650796 hasAuthorship W4225650796A5009075899 @default.
• W4225650796 hasAuthorship W4225650796A5011091618 @default.
• W4225650796 hasAuthorship W4225650796A5039570583 @default.
• W4225650796 hasAuthorship W4225650796A5047631647 @default.
• W4225650796 hasAuthorship W4225650796A5057821484 @default.
• W4225650796 hasAuthorship W4225650796A5084346395 @default.
• W4225650796 hasAuthorship W4225650796A5091752515 @default.
• W4225650796 hasBestOaLocation W42256507961 @default.
• W4225650796 hasConcept C10138342 @default.
• W4225650796 hasConcept C118518473 @default.
• W4225650796 hasConcept C118552586 @default.
• W4225650796 hasConcept C121242521 @default.
• W4225650796 hasConcept C142724271 @default.
• W4225650796 hasConcept C144133560 @default.
• W4225650796 hasConcept C145097563 @default.
• W4225650796 hasConcept C153997805 @default.
• W4225650796 hasConcept C156005406 @default.
• W4225650796 hasConcept C15744967 @default.
• W4225650796 hasConcept C166957645 @default.
• W4225650796 hasConcept C17744445 @default.
• W4225650796 hasConcept C188084074 @default.
• W4225650796 hasConcept C199539241 @default.
• W4225650796 hasConcept C203014093 @default.

• next