Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225659890> ?p ?o ?g. }
- W4225659890 endingPage "3708" @default.
- W4225659890 startingPage "3693" @default.
- W4225659890 abstract "Periodic gene expression dynamics are key to cell and organism physiology. Studies of oscillatory expression have focused on networks with intuitive regulatory negative feedback loops, leaving unknown whether other common biochemical reactions can produce oscillations. Oscillation and noise have been proposed to support mammalian progenitor cells' capacity to restore heterogenous, multimodal expression from extreme subpopulations, but underlying networks and specific roles of noise remained elusive. We use mass-action-based models to show that regulated RNA degradation involving as few as two RNA species-applicable to nearly half of human protein-coding genes-can generate sustained oscillations without explicit feedback. Diverging oscillation periods synergize with noise to robustly restore cell populations' bimodal expression on timescales of days. The global bifurcation organizing this divergence relies on an oscillator and bistable switch which cannot be decomposed into two structural modules. Our work reveals surprisingly rich dynamics of post-transcriptional reactions and a potentially widespread mechanism underlying development, tissue regeneration, and cancer cell heterogeneity." @default.
- W4225659890 created "2022-05-05" @default.
- W4225659890 creator A5007686024 @default.
- W4225659890 creator A5066374461 @default.
- W4225659890 creator A5072122666 @default.
- W4225659890 creator A5080899968 @default.
- W4225659890 date "2022-04-05" @default.
- W4225659890 modified "2023-10-14" @default.
- W4225659890 title "Nonmodular oscillator and switch based on RNA decay drive regeneration of multimodal gene expression" @default.
- W4225659890 cites W1645305843 @default.
- W4225659890 cites W1967066846 @default.
- W4225659890 cites W1980561748 @default.
- W4225659890 cites W1989900581 @default.
- W4225659890 cites W1991425207 @default.
- W4225659890 cites W1994500037 @default.
- W4225659890 cites W1997443428 @default.
- W4225659890 cites W1998819524 @default.
- W4225659890 cites W2000619385 @default.
- W4225659890 cites W2003503318 @default.
- W4225659890 cites W2020596227 @default.
- W4225659890 cites W2023398004 @default.
- W4225659890 cites W2025549697 @default.
- W4225659890 cites W2030945597 @default.
- W4225659890 cites W2035824523 @default.
- W4225659890 cites W2038819846 @default.
- W4225659890 cites W2043946672 @default.
- W4225659890 cites W2050444114 @default.
- W4225659890 cites W2052799855 @default.
- W4225659890 cites W2053156756 @default.
- W4225659890 cites W2053490054 @default.
- W4225659890 cites W2058955985 @default.
- W4225659890 cites W2059073003 @default.
- W4225659890 cites W2061174980 @default.
- W4225659890 cites W2071147887 @default.
- W4225659890 cites W2073586815 @default.
- W4225659890 cites W2075040103 @default.
- W4225659890 cites W2106014350 @default.
- W4225659890 cites W2106362845 @default.
- W4225659890 cites W2111510713 @default.
- W4225659890 cites W2114870653 @default.
- W4225659890 cites W2125198788 @default.
- W4225659890 cites W2127403997 @default.
- W4225659890 cites W2132278571 @default.
- W4225659890 cites W2133351686 @default.
- W4225659890 cites W2134394278 @default.
- W4225659890 cites W2134629862 @default.
- W4225659890 cites W2141688036 @default.
- W4225659890 cites W2142806844 @default.
- W4225659890 cites W2143145944 @default.
- W4225659890 cites W2147078972 @default.
- W4225659890 cites W2155131748 @default.
- W4225659890 cites W2157886337 @default.
- W4225659890 cites W2159793493 @default.
- W4225659890 cites W2164925597 @default.
- W4225659890 cites W2168221215 @default.
- W4225659890 cites W2174187976 @default.
- W4225659890 cites W2174734928 @default.
- W4225659890 cites W2177744475 @default.
- W4225659890 cites W2178975387 @default.
- W4225659890 cites W2260902767 @default.
- W4225659890 cites W2300489152 @default.
- W4225659890 cites W2380368735 @default.
- W4225659890 cites W2407256865 @default.
- W4225659890 cites W2500689306 @default.
- W4225659890 cites W2512004978 @default.
- W4225659890 cites W2518828632 @default.
- W4225659890 cites W2524432326 @default.
- W4225659890 cites W2527919097 @default.
- W4225659890 cites W2600688328 @default.
- W4225659890 cites W2609996848 @default.
- W4225659890 cites W2619381903 @default.
- W4225659890 cites W2621895366 @default.
- W4225659890 cites W2782454362 @default.
- W4225659890 cites W2790962488 @default.
- W4225659890 cites W2868772566 @default.
- W4225659890 cites W2884300959 @default.
- W4225659890 cites W2886119735 @default.
- W4225659890 cites W2892730319 @default.
- W4225659890 cites W2898174520 @default.
- W4225659890 cites W2911585371 @default.
- W4225659890 cites W2922397855 @default.
- W4225659890 cites W2950077617 @default.
- W4225659890 cites W2962842478 @default.
- W4225659890 cites W2963934840 @default.
- W4225659890 cites W2963948130 @default.
- W4225659890 cites W2965603720 @default.
- W4225659890 cites W3010309622 @default.
- W4225659890 cites W3048608287 @default.
- W4225659890 cites W3094345105 @default.
- W4225659890 cites W3105797230 @default.
- W4225659890 cites W3107405110 @default.
- W4225659890 cites W3134083665 @default.
- W4225659890 cites W3156668143 @default.
- W4225659890 cites W3186667648 @default.
- W4225659890 cites W3194205397 @default.
- W4225659890 cites W3202556172 @default.
- W4225659890 cites W3204408559 @default.
- W4225659890 cites W3205173002 @default.