FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225674020> ?p ?o ?g. }

• W4225674020 abstract "Degree of expression of programmed death-ligand 1 (PD-L1) is related with Immune check point inhibitors (ICIs) response but it needs sufficient tumor tissue. There is unmet need for easily accessible and prognostic peripheral blood (PB) biomarkers. We investigated the application of serum peripheral lymphocyte count (PLC) as a predictive PB biomarker for ICI response in patients with NSCLC. We conducted a retrospective study and reviewed the patients with NSCLC who were treated with ICIs from April 1, 2016, to March 31, 2019. The PLC before and after 1 month of immunotherapy was collected. We evaluated the association between PLC and progression-free survival (PFS), overall survival (OS) and adverse events. A total of 231 patients were treated with ICIs for NSCLC. The median follow-up period was 4.7 months and the disease progressed in 138 patients (59.7%). Compared with the lowest quartile (Q1: the lowest 25%), the highest quartile (Q4: the highest 25%) of post-treatment PLC showed a significantly higher PFS (HR 0.28, 95% CI 0.16-0.52) and OS (HR 0.35, 95% CI 0.19-0.65) in the adjusted model. An association between adverse events and PLC was not observed. We revealed that an increased pre- and post-treatment PLC was associated with favorable PFS and OS with NSCLC patients treated with ICIs. PLC could be a helpful for ICI responses in NSCLC." @default.
• W4225674020 created "2022-05-05" @default.
• W4225674020 creator A5003756007 @default.
• W4225674020 creator A5026874845 @default.
• W4225674020 creator A5038725268 @default.
• W4225674020 creator A5046563074 @default.
• W4225674020 creator A5073626707 @default.
• W4225674020 creator A5087503438 @default.
• W4225674020 date "2022-01-12" @default.
• W4225674020 modified "2023-10-02" @default.
• W4225674020 title "Peripheral lymphocyte count as a surrogate marker of immune checkpoint inhibitor therapy outcomes in patients with non-small-cell lung cancer" @default.
• W4225674020 cites W1795565596 @default.
• W4225674020 cites W1996668651 @default.
• W4225674020 cites W2020914260 @default.
• W4225674020 cites W2053991659 @default.
• W4225674020 cites W2061590134 @default.
• W4225674020 cites W2075691289 @default.
• W4225674020 cites W2075879891 @default.
• W4225674020 cites W2089437237 @default.
• W4225674020 cites W2104347254 @default.
• W4225674020 cites W2141293913 @default.
• W4225674020 cites W2142598717 @default.
• W4225674020 cites W2148237316 @default.
• W4225674020 cites W2152061559 @default.
• W4225674020 cites W2156353875 @default.
• W4225674020 cites W2198093519 @default.
• W4225674020 cites W2212074200 @default.
• W4225674020 cites W2262857054 @default.
• W4225674020 cites W2415251397 @default.
• W4225674020 cites W2478891054 @default.
• W4225674020 cites W2534958209 @default.
• W4225674020 cites W2560367415 @default.
• W4225674020 cites W2572174216 @default.
• W4225674020 cites W2592144107 @default.
• W4225674020 cites W2609289346 @default.
• W4225674020 cites W2762777471 @default.
• W4225674020 cites W2767225644 @default.
• W4225674020 cites W2782676239 @default.
• W4225674020 cites W2789601009 @default.
• W4225674020 cites W2789677706 @default.
• W4225674020 cites W2791483720 @default.
• W4225674020 cites W2796493064 @default.
• W4225674020 cites W2796929908 @default.
• W4225674020 cites W2797608722 @default.
• W4225674020 cites W2797675588 @default.
• W4225674020 cites W2892951532 @default.
• W4225674020 cites W2894582328 @default.
• W4225674020 cites W2900657494 @default.
• W4225674020 cites W2910937665 @default.
• W4225674020 cites W2944860885 @default.
• W4225674020 cites W2974999760 @default.
• W4225674020 cites W3005834155 @default.
• W4225674020 cites W4288283969 @default.
• W4225674020 doi "https://doi.org/10.1038/s41598-021-04630-9" @default.
• W4225674020 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35022510" @default.
• W4225674020 hasPublicationYear "2022" @default.
• W4225674020 type Work @default.
• W4225674020 citedByCount "11" @default.
• W4225674020 countsByYear W42256740202022 @default.
• W4225674020 countsByYear W42256740202023 @default.
• W4225674020 crossrefType "journal-article" @default.
• W4225674020 hasAuthorship W4225674020A5003756007 @default.
• W4225674020 hasAuthorship W4225674020A5026874845 @default.
• W4225674020 hasAuthorship W4225674020A5038725268 @default.
• W4225674020 hasAuthorship W4225674020A5046563074 @default.
• W4225674020 hasAuthorship W4225674020A5073626707 @default.
• W4225674020 hasAuthorship W4225674020A5087503438 @default.
• W4225674020 hasBestOaLocation W42256740201 @default.
• W4225674020 hasConcept C121608353 @default.
• W4225674020 hasConcept C126322002 @default.
• W4225674020 hasConcept C141341695 @default.
• W4225674020 hasConcept C143998085 @default.
• W4225674020 hasConcept C167135981 @default.
• W4225674020 hasConcept C168563851 @default.
• W4225674020 hasConcept C185592680 @default.
• W4225674020 hasConcept C197934379 @default.
• W4225674020 hasConcept C203014093 @default.
• W4225674020 hasConcept C203092338 @default.
• W4225674020 hasConcept C2776256026 @default.
• W4225674020 hasConcept C2777701055 @default.
• W4225674020 hasConcept C2777761686 @default.
• W4225674020 hasConcept C2781197716 @default.
• W4225674020 hasConcept C44249647 @default.
• W4225674020 hasConcept C46762472 @default.
• W4225674020 hasConcept C50382708 @default.
• W4225674020 hasConcept C55493867 @default.
• W4225674020 hasConcept C68443243 @default.
• W4225674020 hasConcept C71924100 @default.
• W4225674020 hasConcept C8891405 @default.
• W4225674020 hasConcept C90924648 @default.
• W4225674020 hasConceptScore W4225674020C121608353 @default.
• W4225674020 hasConceptScore W4225674020C126322002 @default.
• W4225674020 hasConceptScore W4225674020C141341695 @default.
• W4225674020 hasConceptScore W4225674020C143998085 @default.
• W4225674020 hasConceptScore W4225674020C167135981 @default.
• W4225674020 hasConceptScore W4225674020C168563851 @default.
• W4225674020 hasConceptScore W4225674020C185592680 @default.
• W4225674020 hasConceptScore W4225674020C197934379 @default.
• W4225674020 hasConceptScore W4225674020C203014093 @default.
• W4225674020 hasConceptScore W4225674020C203092338 @default.

• next