FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225680065> ?p ?o ?g. }

• W4225680065 endingPage "496" @default.
• W4225680065 startingPage "484" @default.
• W4225680065 abstract "Cancer therapy frequently fails due to the emergence of resistance. Many tumors include phenotypically immature tumor cells, which have been implicated in therapy resistance. Neuroblastoma cells can adopt a lineage-committed adrenergic (ADRN) or an immature mesenchymal (MES) state. They differ in epigenetic landscape and transcription factors, and MES cells are more resistant to chemotherapy. Here we analyzed the response of MES cells to targeted drugs. Activating anaplastic lymphoma kinase (ALK) mutations are frequently found in neuroblastoma and ALK inhibitors (ALKi) are in clinical trials. ALKi treatment of ADRN neuroblastoma cells with a tumor-driving ALK mutation induced cell death. Conversely, MES cells did not express either mutant or wild-type ALK and were resistant to ALKi, and MES cells formed tumors that progressed under ALKi therapy. In assessing the role of MES cells in relapse development, TRAIL was identified to specifically induce apoptosis in MES cells and to suppress MES tumor growth. Addition of TRAIL to ALKi treatment of neuroblastoma xenografts delayed relapses in a subset of the animals, suggesting a role for MES cells in relapse formation. While ADRN cells resembled normal embryonal neuroblasts, MES cells resembled immature precursor cells, which also lacked ALK expression. Resistance to targeted drugs can therefore be an intrinsic property of immature cancer cells based on their resemblance to developmental precursors. SIGNIFICANCE: In neuroblastoma, mesenchymal tumor cells lack expression of the tumor-driving ALK oncogene and are resistant to ALKi, but dual treatment with ALKi and mesenchymal cell-targeting TRAIL delays tumor relapse." @default.
• W4225680065 created "2022-05-05" @default.
• W4225680065 creator A5004371463 @default.
• W4225680065 creator A5005937429 @default.
• W4225680065 creator A5010154184 @default.
• W4225680065 creator A5020869847 @default.
• W4225680065 creator A5025711138 @default.
• W4225680065 creator A5030370050 @default.
• W4225680065 creator A5039407364 @default.
• W4225680065 creator A5042638480 @default.
• W4225680065 creator A5044156327 @default.
• W4225680065 creator A5046131129 @default.
• W4225680065 creator A5053808178 @default.
• W4225680065 creator A5058332134 @default.
• W4225680065 creator A5059764970 @default.
• W4225680065 creator A5062389932 @default.
• W4225680065 creator A5064588631 @default.
• W4225680065 creator A5074069398 @default.
• W4225680065 creator A5075272520 @default.
• W4225680065 creator A5076800395 @default.
• W4225680065 creator A5081239513 @default.
• W4225680065 creator A5086033960 @default.
• W4225680065 creator A5091191169 @default.
• W4225680065 date "2021-12-01" @default.
• W4225680065 modified "2023-10-10" @default.
• W4225680065 title "Mesenchymal-Type Neuroblastoma Cells Escape ALK Inhibitors" @default.
• W4225680065 cites W1493594926 @default.
• W4225680065 cites W1971578941 @default.
• W4225680065 cites W2004966039 @default.
• W4225680065 cites W2010978319 @default.
• W4225680065 cites W2022354436 @default.
• W4225680065 cites W2032767287 @default.
• W4225680065 cites W2035282066 @default.
• W4225680065 cites W2044936103 @default.
• W4225680065 cites W2052005627 @default.
• W4225680065 cites W2052801268 @default.
• W4225680065 cites W2060275730 @default.
• W4225680065 cites W2063337289 @default.
• W4225680065 cites W2066417528 @default.
• W4225680065 cites W2103600998 @default.
• W4225680065 cites W2124140824 @default.
• W4225680065 cites W2125290561 @default.
• W4225680065 cites W2127956110 @default.
• W4225680065 cites W2158416296 @default.
• W4225680065 cites W2168768703 @default.
• W4225680065 cites W2261133602 @default.
• W4225680065 cites W2344709972 @default.
• W4225680065 cites W2546514099 @default.
• W4225680065 cites W2551595687 @default.
• W4225680065 cites W2603523955 @default.
• W4225680065 cites W2613058366 @default.
• W4225680065 cites W2702680930 @default.
• W4225680065 cites W2726594986 @default.
• W4225680065 cites W2738563754 @default.
• W4225680065 cites W2783011222 @default.
• W4225680065 cites W2802053370 @default.
• W4225680065 cites W2807677124 @default.
• W4225680065 cites W2884607428 @default.
• W4225680065 cites W2911858378 @default.
• W4225680065 cites W2934396339 @default.
• W4225680065 cites W2962905556 @default.
• W4225680065 cites W2965076400 @default.
• W4225680065 cites W3081464583 @default.
• W4225680065 cites W3086206613 @default.
• W4225680065 cites W3112137768 @default.
• W4225680065 cites W3128250744 @default.
• W4225680065 cites W3128720712 @default.
• W4225680065 cites W3134770103 @default.
• W4225680065 cites W3137366663 @default.
• W4225680065 cites W3145462477 @default.
• W4225680065 cites W3167360675 @default.
• W4225680065 cites W4211147182 @default.
• W4225680065 doi "https://doi.org/10.1158/0008-5472.can-21-1621" @default.
• W4225680065 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34853072" @default.
• W4225680065 hasPublicationYear "2021" @default.
• W4225680065 type Work @default.
• W4225680065 citedByCount "12" @default.
• W4225680065 countsByYear W42256800652022 @default.
• W4225680065 countsByYear W42256800652023 @default.
• W4225680065 crossrefType "journal-article" @default.
• W4225680065 hasAuthorship W4225680065A5004371463 @default.
• W4225680065 hasAuthorship W4225680065A5005937429 @default.
• W4225680065 hasAuthorship W4225680065A5010154184 @default.
• W4225680065 hasAuthorship W4225680065A5020869847 @default.
• W4225680065 hasAuthorship W4225680065A5025711138 @default.
• W4225680065 hasAuthorship W4225680065A5030370050 @default.
• W4225680065 hasAuthorship W4225680065A5039407364 @default.
• W4225680065 hasAuthorship W4225680065A5042638480 @default.
• W4225680065 hasAuthorship W4225680065A5044156327 @default.
• W4225680065 hasAuthorship W4225680065A5046131129 @default.
• W4225680065 hasAuthorship W4225680065A5053808178 @default.
• W4225680065 hasAuthorship W4225680065A5058332134 @default.
• W4225680065 hasAuthorship W4225680065A5059764970 @default.
• W4225680065 hasAuthorship W4225680065A5062389932 @default.
• W4225680065 hasAuthorship W4225680065A5064588631 @default.
• W4225680065 hasAuthorship W4225680065A5074069398 @default.
• W4225680065 hasAuthorship W4225680065A5075272520 @default.
• W4225680065 hasAuthorship W4225680065A5076800395 @default.

• next