Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225680954> ?p ?o ?g. }
- W4225680954 endingPage "5833" @default.
- W4225680954 startingPage "5818" @default.
- W4225680954 abstract "Abstract The assembly of high molecular mass ribonucleoprotein complexes typically relies on the binary interaction of defined RNA sequences or precisely folded RNA motifs with dedicated RNA-binding domains on the protein side. Here we describe a new molecular recognition principle of RNA molecules by a high molecular mass protein complex. By chemically probing the solvent accessibility of mitochondrial pre-mRNAs when bound to the Trypanosoma brucei editosome, we identified multiple similar but non-identical RNA motifs as editosome contact sites. However, by treating the different motifs as mathematical graph objects we demonstrate that they fit a consensus 2D-graph consisting of 4 vertices (V) and 3 edges (E) with a Laplacian eigenvalue of 0.5477 (λ2). We establish that synthetic 4V(3E)-RNAs are sufficient to compete for the editosomal pre-mRNA binding site and that they inhibit RNA editing in vitro. Furthermore, we demonstrate that only two topological indices are necessary to predict the binding of any RNA motif to the editosome with a high level of confidence. Our analysis corroborates that the editosome has adapted to the structural multiplicity of the mitochondrial mRNA folding space by recognizing a fuzzy continuum of RNA folds that fit a consensus graph descriptor." @default.
- W4225680954 created "2022-05-05" @default.
- W4225680954 creator A5063814653 @default.
- W4225680954 date "2022-05-17" @default.
- W4225680954 modified "2023-10-18" @default.
- W4225680954 title "OUP accepted manuscript" @default.
- W4225680954 cites W1625699506 @default.
- W4225680954 cites W1650372104 @default.
- W4225680954 cites W1774947891 @default.
- W4225680954 cites W1842452185 @default.
- W4225680954 cites W1974747849 @default.
- W4225680954 cites W1983505024 @default.
- W4225680954 cites W1991138622 @default.
- W4225680954 cites W2000500223 @default.
- W4225680954 cites W2004283265 @default.
- W4225680954 cites W2021229217 @default.
- W4225680954 cites W2021639635 @default.
- W4225680954 cites W2023514407 @default.
- W4225680954 cites W2030790862 @default.
- W4225680954 cites W2034133446 @default.
- W4225680954 cites W2043757580 @default.
- W4225680954 cites W2046966555 @default.
- W4225680954 cites W2056151289 @default.
- W4225680954 cites W2080348578 @default.
- W4225680954 cites W2082038343 @default.
- W4225680954 cites W2086561953 @default.
- W4225680954 cites W2088845970 @default.
- W4225680954 cites W2090046658 @default.
- W4225680954 cites W2096327663 @default.
- W4225680954 cites W2100139545 @default.
- W4225680954 cites W2106632741 @default.
- W4225680954 cites W2111852544 @default.
- W4225680954 cites W2115463474 @default.
- W4225680954 cites W2118688581 @default.
- W4225680954 cites W2121289117 @default.
- W4225680954 cites W2124555115 @default.
- W4225680954 cites W2131592707 @default.
- W4225680954 cites W2138859947 @default.
- W4225680954 cites W2142068708 @default.
- W4225680954 cites W2143416770 @default.
- W4225680954 cites W2145594096 @default.
- W4225680954 cites W2163646378 @default.
- W4225680954 cites W2214103070 @default.
- W4225680954 cites W2267790137 @default.
- W4225680954 cites W2302990590 @default.
- W4225680954 cites W2318794083 @default.
- W4225680954 cites W2321301219 @default.
- W4225680954 cites W2340257497 @default.
- W4225680954 cites W2396676392 @default.
- W4225680954 cites W2396866349 @default.
- W4225680954 cites W2409601037 @default.
- W4225680954 cites W2488347478 @default.
- W4225680954 cites W259468590 @default.
- W4225680954 cites W2625742743 @default.
- W4225680954 cites W2761730841 @default.
- W4225680954 cites W2794527405 @default.
- W4225680954 cites W2794654572 @default.
- W4225680954 cites W2796420015 @default.
- W4225680954 cites W2808035792 @default.
- W4225680954 cites W2884698972 @default.
- W4225680954 cites W2886834918 @default.
- W4225680954 cites W2920949012 @default.
- W4225680954 cites W2949907488 @default.
- W4225680954 cites W2997552612 @default.
- W4225680954 cites W3004193861 @default.
- W4225680954 cites W3007953280 @default.
- W4225680954 cites W3015191920 @default.
- W4225680954 cites W3031661900 @default.
- W4225680954 cites W3046952964 @default.
- W4225680954 cites W3082079732 @default.
- W4225680954 cites W3104929221 @default.
- W4225680954 cites W3105676248 @default.
- W4225680954 cites W3127370042 @default.
- W4225680954 cites W3133756645 @default.
- W4225680954 cites W3134841589 @default.
- W4225680954 cites W69557463 @default.
- W4225680954 cites W70041852 @default.
- W4225680954 doi "https://doi.org/10.1093/nar/gkac357" @default.
- W4225680954 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35580050" @default.
- W4225680954 hasPublicationYear "2022" @default.
- W4225680954 type Work @default.
- W4225680954 citedByCount "0" @default.
- W4225680954 crossrefType "journal-article" @default.
- W4225680954 hasAuthorship W4225680954A5063814653 @default.
- W4225680954 hasBestOaLocation W42256809541 @default.
- W4225680954 hasConcept C104317684 @default.
- W4225680954 hasConcept C21786251 @default.
- W4225680954 hasConcept C41282012 @default.
- W4225680954 hasConcept C54355233 @default.
- W4225680954 hasConcept C67705224 @default.
- W4225680954 hasConcept C70721500 @default.
- W4225680954 hasConcept C86803240 @default.
- W4225680954 hasConceptScore W4225680954C104317684 @default.
- W4225680954 hasConceptScore W4225680954C21786251 @default.
- W4225680954 hasConceptScore W4225680954C41282012 @default.
- W4225680954 hasConceptScore W4225680954C54355233 @default.
- W4225680954 hasConceptScore W4225680954C67705224 @default.
- W4225680954 hasConceptScore W4225680954C70721500 @default.