Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225687670> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W4225687670 endingPage "379" @default.
- W4225687670 startingPage "368" @default.
- W4225687670 abstract "In the present study, the various 28 hybrid molecules containing hydrazone and sulfonate moieties were synthesized and characterized by FTIR, 1H-NMR, 13C-NMR spectroscopy and LC-MS spectrometry, besides elemental analysis. The compounds were evaluated for their antiproliferative effects against six cancer cell lines, namely A549 (non-small cell lung cancer), MCF-7 (breast cancer), HT-29 (colorectal adenocarcinoma cancer), PC-3 (androgen-independent prostate adenocarcinoma), Hep3B (hepatocellular carcinoma cancer), and HeLa (epitheloid cervix carcinoma cancer). Among all the target compounds, compounds 4g and 4h exhibited more promising effects on MCF-7 cell lines (IC50 = 17.8 μM and 21.2 μM, respectively) with high selectivity. Further mechanistic studies proposed that compounds 4g and 4h induced apoptosis is mediated through the intrinsic apoptotic pathway with changes in mitochondrial membrane potential by finally activating caspase-9 and caspase-3. The results have been encouraging enough to merit further investigation." @default.
- W4225687670 created "2022-05-05" @default.
- W4225687670 creator A5032459006 @default.
- W4225687670 creator A5036044562 @default.
- W4225687670 creator A5062530717 @default.
- W4225687670 creator A5066788214 @default.
- W4225687670 creator A5090251293 @default.
- W4225687670 date "2022-01-12" @default.
- W4225687670 modified "2023-10-01" @default.
- W4225687670 title "Synthesis and anticancer activity of novel hydrazone linkage-based aryl sulfonate derivatives as apoptosis inducers" @default.
- W4225687670 cites W1747141272 @default.
- W4225687670 cites W1821524109 @default.
- W4225687670 cites W1968789769 @default.
- W4225687670 cites W1972002031 @default.
- W4225687670 cites W1982485600 @default.
- W4225687670 cites W1991099024 @default.
- W4225687670 cites W2010600886 @default.
- W4225687670 cites W2016918418 @default.
- W4225687670 cites W2024004416 @default.
- W4225687670 cites W2044494267 @default.
- W4225687670 cites W2090186784 @default.
- W4225687670 cites W2114421026 @default.
- W4225687670 cites W2115268409 @default.
- W4225687670 cites W2117439709 @default.
- W4225687670 cites W2128327274 @default.
- W4225687670 cites W2339596429 @default.
- W4225687670 cites W2408954743 @default.
- W4225687670 cites W2599697263 @default.
- W4225687670 cites W2617724428 @default.
- W4225687670 cites W2767354031 @default.
- W4225687670 cites W2809693898 @default.
- W4225687670 cites W2950110168 @default.
- W4225687670 cites W2958236707 @default.
- W4225687670 cites W2988903075 @default.
- W4225687670 cites W3014587951 @default.
- W4225687670 cites W3044689521 @default.
- W4225687670 cites W3107034041 @default.
- W4225687670 cites W3139122527 @default.
- W4225687670 doi "https://doi.org/10.1007/s00044-021-02837-z" @default.
- W4225687670 hasPublicationYear "2022" @default.
- W4225687670 type Work @default.
- W4225687670 citedByCount "12" @default.
- W4225687670 countsByYear W42256876702022 @default.
- W4225687670 countsByYear W42256876702023 @default.
- W4225687670 crossrefType "journal-article" @default.
- W4225687670 hasAuthorship W4225687670A5032459006 @default.
- W4225687670 hasAuthorship W4225687670A5036044562 @default.
- W4225687670 hasAuthorship W4225687670A5062530717 @default.
- W4225687670 hasAuthorship W4225687670A5066788214 @default.
- W4225687670 hasAuthorship W4225687670A5090251293 @default.
- W4225687670 hasBestOaLocation W42256876702 @default.
- W4225687670 hasConcept C1491633281 @default.
- W4225687670 hasConcept C185592680 @default.
- W4225687670 hasConcept C190283241 @default.
- W4225687670 hasConcept C2777366897 @default.
- W4225687670 hasConcept C2780349576 @default.
- W4225687670 hasConcept C502942594 @default.
- W4225687670 hasConcept C55493867 @default.
- W4225687670 hasConcept C71240020 @default.
- W4225687670 hasConcept C86803240 @default.
- W4225687670 hasConceptScore W4225687670C1491633281 @default.
- W4225687670 hasConceptScore W4225687670C185592680 @default.
- W4225687670 hasConceptScore W4225687670C190283241 @default.
- W4225687670 hasConceptScore W4225687670C2777366897 @default.
- W4225687670 hasConceptScore W4225687670C2780349576 @default.
- W4225687670 hasConceptScore W4225687670C502942594 @default.
- W4225687670 hasConceptScore W4225687670C55493867 @default.
- W4225687670 hasConceptScore W4225687670C71240020 @default.
- W4225687670 hasConceptScore W4225687670C86803240 @default.
- W4225687670 hasIssue "2" @default.
- W4225687670 hasLocation W42256876701 @default.
- W4225687670 hasLocation W42256876702 @default.
- W4225687670 hasOpenAccess W4225687670 @default.
- W4225687670 hasPrimaryLocation W42256876701 @default.
- W4225687670 hasRelatedWork W2357919285 @default.
- W4225687670 hasRelatedWork W2361688784 @default.
- W4225687670 hasRelatedWork W2367968865 @default.
- W4225687670 hasRelatedWork W2374614804 @default.
- W4225687670 hasRelatedWork W2374725308 @default.
- W4225687670 hasRelatedWork W2375119081 @default.
- W4225687670 hasRelatedWork W2391226321 @default.
- W4225687670 hasRelatedWork W2392484830 @default.
- W4225687670 hasRelatedWork W2393570706 @default.
- W4225687670 hasRelatedWork W2463320161 @default.
- W4225687670 hasVolume "31" @default.
- W4225687670 isParatext "false" @default.
- W4225687670 isRetracted "false" @default.
- W4225687670 workType "article" @default.