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- W4225692552 endingPage "21.2021" @default.
- W4225692552 startingPage "ENEURO.0364" @default.
- W4225692552 abstract "Sensorimotor circuits of the lumbosacral spinal cord are required for lower urinary tract (LUT) regulation as well as being engaged in pelvic pain states. To date, no molecular markers have been identified to enable specific visualization of LUT afferents, which are embedded within spinal cord segments that also subserve somatic functions. Moreover, previous studies have not fully investigated the patterning within or across spinal segments, compared afferent innervation of the bladder and urethra, or explored possible structural sex differences in these pathways. We have addressed these questions in adult Sprague Dawley rats, using intramural microinjection of the tract tracer, B subunit of cholera toxin (CTB). Afferent distribution was analyzed within individual sections and 3D reconstructions from sections across four spinal cord segments (L5-S2), and in cleared intact spinal cord viewed with light sheet microscopy. Simultaneous mapping of preganglionic neurons showed their location throughout S1 but restricted to the caudal half of L6. Afferents from both LUT regions extended from L5 to S2, even where preganglionic motor pathways were absent. In L6 and S1, most afferents were associated with the sacral preganglionic nucleus (SPN) and sacral dorsal commissural nucleus (SDCom), with very few in the superficial laminae of the dorsal horn. Spinal innervation patterns by bladder and urethra afferents were remarkably similar, likewise the patterning in male and female rats. In conclusion, microscale to macroscale mapping has identified distinct features of LUT afferent projections to the lumbosacral cord and provided a new anatomic approach for future studies on plasticity, injury responses, and modeling of these pathways." @default.
- W4225692552 created "2022-05-05" @default.
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- W4225692552 date "2021-11-01" @default.
- W4225692552 modified "2023-09-29" @default.
- W4225692552 title "Regional Targeting of Bladder and Urethra Afferents in the Lumbosacral Spinal Cord of Male and Female Rats: A Multiscale Analysis" @default.
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- W4225692552 cites W1939566450 @default.
- W4225692552 cites W1966507881 @default.
- W4225692552 cites W1966784515 @default.
- W4225692552 cites W1969325149 @default.
- W4225692552 cites W1978158369 @default.
- W4225692552 cites W1980559971 @default.
- W4225692552 cites W198067126 @default.
- W4225692552 cites W1989252415 @default.
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- W4225692552 cites W2001814576 @default.
- W4225692552 cites W2008503082 @default.
- W4225692552 cites W2008969125 @default.
- W4225692552 cites W2011491345 @default.
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- W4225692552 cites W2017022213 @default.
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- W4225692552 cites W2065590582 @default.
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- W4225692552 cites W2101340042 @default.
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- W4225692552 cites W2907052726 @default.
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- W4225692552 doi "https://doi.org/10.1523/eneuro.0364-21.2021" @default.
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