FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225714471> ?p ?o ?g. }

• W4225714471 endingPage "1116" @default.
• W4225714471 startingPage "1103" @default.
• W4225714471 abstract "The availability of new classes of antiretroviral drugs is critical for treatment-experienced patients due to drug resistance to and unwanted side effects from current drugs. Our aim was therefore to evaluate the anti-HIV-1 activity of a new set of antivirals, dipeptides (WG-am or VQ-am) combined with a single-stranded oligonucleotide (ssON). The dipeptides were identified as naturally occurring and enriched in feces and systemic circulation in HIV-1-infected elite controllers and were proposed to act as entry inhibitors by binding to HIV-1 gp120. The ssON is DNA 35-mer, stabilized by phosphorothioate modifications, which acts on the endocytic step by binding to cell host receptors and inhibiting viruses through interference with binding to nucleolin.Chou-Talalay's Combination Index method for quantifying synergism was used to evaluate the drug combinations. Patient-derived chimeric viruses encoding the gp120 (env region) were produced by transient transfection and used to evaluate the antiviral profile of the combinations by drug susceptibility assays.We found that the combination WG-am:ssON or VQ-am:ssON had low combination index values, suggesting strong antiviral synergism. Of the two combinations, WG-am:ssON (1 mM:1 μM) had high efficacy against all prototype or patient-derived HIV-1 isolates tested, independent of subtype including the HIV-1-A6 sub-subtype. In addition, the antiviral effect was independent of co-receptor usage in patient-derived strains.WG-am and ssON alone significantly inhibited HIV-1 replication regardless of viral subtype and co-receptor usage, and the combination WG-am:ssON (1 mM:1 μM) was even more effective due to synergism." @default.
• W4225714471 created "2022-05-05" @default.
• W4225714471 creator A5009876808 @default.
• W4225714471 creator A5034073363 @default.
• W4225714471 creator A5039969623 @default.
• W4225714471 creator A5049782797 @default.
• W4225714471 date "2022-04-07" @default.
• W4225714471 modified "2023-10-18" @default.
• W4225714471 title "Novel Naturally Occurring Dipeptides and Single-Stranded Oligonucleotide Act as Entry Inhibitors and Exhibit a Strong Synergistic Anti-HIV-1 Profile" @default.
• W4225714471 cites W1964364336 @default.
• W4225714471 cites W1974543288 @default.
• W4225714471 cites W1999048558 @default.
• W4225714471 cites W2063295801 @default.
• W4225714471 cites W2077945404 @default.
• W4225714471 cites W2096439168 @default.
• W4225714471 cites W2096495877 @default.
• W4225714471 cites W2111428445 @default.
• W4225714471 cites W2113446109 @default.
• W4225714471 cites W2119146932 @default.
• W4225714471 cites W2122210884 @default.
• W4225714471 cites W2129719419 @default.
• W4225714471 cites W2138289438 @default.
• W4225714471 cites W2140478082 @default.
• W4225714471 cites W2570679128 @default.
• W4225714471 cites W2570738774 @default.
• W4225714471 cites W2605885576 @default.
• W4225714471 cites W2620616353 @default.
• W4225714471 cites W2777971517 @default.
• W4225714471 cites W2779839150 @default.
• W4225714471 cites W2794439426 @default.
• W4225714471 cites W2884122408 @default.
• W4225714471 cites W2897002724 @default.
• W4225714471 cites W2901716534 @default.
• W4225714471 cites W2903782576 @default.
• W4225714471 cites W2955527495 @default.
• W4225714471 cites W2970206200 @default.
• W4225714471 cites W2970256309 @default.
• W4225714471 cites W2996685553 @default.
• W4225714471 cites W3021802132 @default.
• W4225714471 cites W3030947224 @default.
• W4225714471 cites W3046561496 @default.
• W4225714471 cites W3108424837 @default.
• W4225714471 cites W3112126666 @default.
• W4225714471 cites W3112455680 @default.
• W4225714471 cites W3137565606 @default.
• W4225714471 cites W3179279869 @default.
• W4225714471 doi "https://doi.org/10.1007/s40121-022-00626-8" @default.
• W4225714471 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35391633" @default.
• W4225714471 hasPublicationYear "2022" @default.
• W4225714471 type Work @default.
• W4225714471 citedByCount "4" @default.
• W4225714471 countsByYear W42257144712022 @default.
• W4225714471 countsByYear W42257144712023 @default.
• W4225714471 crossrefType "journal-article" @default.
• W4225714471 hasAuthorship W4225714471A5009876808 @default.
• W4225714471 hasAuthorship W4225714471A5034073363 @default.
• W4225714471 hasAuthorship W4225714471A5039969623 @default.
• W4225714471 hasAuthorship W4225714471A5049782797 @default.
• W4225714471 hasBestOaLocation W42257144711 @default.
• W4225714471 hasConcept C129312508 @default.
• W4225714471 hasConcept C140704245 @default.
• W4225714471 hasConcept C159047783 @default.
• W4225714471 hasConcept C170493617 @default.
• W4225714471 hasConcept C183873130 @default.
• W4225714471 hasConcept C190062978 @default.
• W4225714471 hasConcept C2522874641 @default.
• W4225714471 hasConcept C2776525860 @default.
• W4225714471 hasConcept C2776997796 @default.
• W4225714471 hasConcept C2780035454 @default.
• W4225714471 hasConcept C28005876 @default.
• W4225714471 hasConcept C3013748606 @default.
• W4225714471 hasConcept C552990157 @default.
• W4225714471 hasConcept C55493867 @default.
• W4225714471 hasConcept C58475186 @default.
• W4225714471 hasConcept C71924100 @default.
• W4225714471 hasConcept C79747257 @default.
• W4225714471 hasConcept C86803240 @default.
• W4225714471 hasConcept C98274493 @default.
• W4225714471 hasConceptScore W4225714471C129312508 @default.
• W4225714471 hasConceptScore W4225714471C140704245 @default.
• W4225714471 hasConceptScore W4225714471C159047783 @default.
• W4225714471 hasConceptScore W4225714471C170493617 @default.
• W4225714471 hasConceptScore W4225714471C183873130 @default.
• W4225714471 hasConceptScore W4225714471C190062978 @default.
• W4225714471 hasConceptScore W4225714471C2522874641 @default.
• W4225714471 hasConceptScore W4225714471C2776525860 @default.
• W4225714471 hasConceptScore W4225714471C2776997796 @default.
• W4225714471 hasConceptScore W4225714471C2780035454 @default.
• W4225714471 hasConceptScore W4225714471C28005876 @default.
• W4225714471 hasConceptScore W4225714471C3013748606 @default.
• W4225714471 hasConceptScore W4225714471C552990157 @default.
• W4225714471 hasConceptScore W4225714471C55493867 @default.
• W4225714471 hasConceptScore W4225714471C58475186 @default.
• W4225714471 hasConceptScore W4225714471C71924100 @default.
• W4225714471 hasConceptScore W4225714471C79747257 @default.
• W4225714471 hasConceptScore W4225714471C86803240 @default.
• W4225714471 hasConceptScore W4225714471C98274493 @default.
• W4225714471 hasFunder F4320321033 @default.

• next