Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225725743> ?p ?o ?g. }
- W4225725743 endingPage "369" @default.
- W4225725743 startingPage "350" @default.
- W4225725743 abstract "Irritable bowel syndrome (IBS) is a common disorder of gut–brain interaction with an increasing prevalence, and its precise aetiology remains unclear. Gut microbiota dysbiosis has been found to be associated with IBS pathogenesis. In addition, a high incidence of bile acid diarrhoea and disturbed bile acid metabolism has been observed in IBS patients. The abundant microorganisms inhabited in human gut have essential functions in bile acid biotransformation, and can immensely affect the size and constitution of bile acid pool. Meanwhile, the alterations of bile acid profile can inversely interfere with the gut microbiota. This review discussed the role of intricate correlations between bile acids and gut microbiota in IBS pathogenesis and delineated the possible molecular mechanisms, mainly the signalling induced by farnesoid X receptor and transmembrane G protein-coupled receptor 5. Besides, some biomarkers for identifying bile acid diarrhoea in IBS population were listed, assisting the diagnosis and classification of IBS. Moreover, it also assessed some therapeutic strategies for IBS that regulate the bile acid–gut microbiota axis, such as dietary modulation, probiotics/prebiotics, faecal microbiota transplantation, and antibiotics. Collectively, this article illustrated the relationship between bile acids and gut microbiota in IBS pathophysiology and might offer some novel therapeutic options for IBS." @default.
- W4225725743 created "2022-05-05" @default.
- W4225725743 creator A5000349249 @default.
- W4225725743 creator A5013236912 @default.
- W4225725743 creator A5016302401 @default.
- W4225725743 creator A5023689602 @default.
- W4225725743 creator A5038032242 @default.
- W4225725743 creator A5038647128 @default.
- W4225725743 creator A5049041942 @default.
- W4225725743 creator A5049490875 @default.
- W4225725743 creator A5063486512 @default.
- W4225725743 creator A5085698762 @default.
- W4225725743 date "2022-04-07" @default.
- W4225725743 modified "2023-10-13" @default.
- W4225725743 title "Bile acid–gut microbiota crosstalk in irritable bowel syndrome" @default.
- W4225725743 cites W1482883615 @default.
- W4225725743 cites W1485938486 @default.
- W4225725743 cites W1559708388 @default.
- W4225725743 cites W1567998653 @default.
- W4225725743 cites W1581234793 @default.
- W4225725743 cites W1588937542 @default.
- W4225725743 cites W1600562837 @default.
- W4225725743 cites W1733923064 @default.
- W4225725743 cites W1756046628 @default.
- W4225725743 cites W1761317375 @default.
- W4225725743 cites W1894632157 @default.
- W4225725743 cites W1964357386 @default.
- W4225725743 cites W1965796890 @default.
- W4225725743 cites W1966906395 @default.
- W4225725743 cites W1968091752 @default.
- W4225725743 cites W1970465623 @default.
- W4225725743 cites W1971384756 @default.
- W4225725743 cites W1974616640 @default.
- W4225725743 cites W1976118863 @default.
- W4225725743 cites W1982917920 @default.
- W4225725743 cites W1985425847 @default.
- W4225725743 cites W1985539406 @default.
- W4225725743 cites W1988779510 @default.
- W4225725743 cites W1988920656 @default.
- W4225725743 cites W1989813246 @default.
- W4225725743 cites W1990065303 @default.
- W4225725743 cites W1990819179 @default.
- W4225725743 cites W1991804239 @default.
- W4225725743 cites W1992676701 @default.
- W4225725743 cites W1998578987 @default.
- W4225725743 cites W2000891332 @default.
- W4225725743 cites W2002456808 @default.
- W4225725743 cites W2003525898 @default.
- W4225725743 cites W2005844485 @default.
- W4225725743 cites W2007435811 @default.
- W4225725743 cites W2014335245 @default.
- W4225725743 cites W2018274907 @default.
- W4225725743 cites W2021173194 @default.
- W4225725743 cites W2021206718 @default.
- W4225725743 cites W2021444563 @default.
- W4225725743 cites W2023123778 @default.
- W4225725743 cites W2023816042 @default.
- W4225725743 cites W2028507955 @default.
- W4225725743 cites W2029354866 @default.
- W4225725743 cites W2035779227 @default.
- W4225725743 cites W2039821896 @default.
- W4225725743 cites W2040743397 @default.
- W4225725743 cites W2041451676 @default.
- W4225725743 cites W2042763169 @default.
- W4225725743 cites W2044635500 @default.
- W4225725743 cites W2048799669 @default.
- W4225725743 cites W2049506766 @default.
- W4225725743 cites W2053176597 @default.
- W4225725743 cites W2053581007 @default.
- W4225725743 cites W2053946842 @default.
- W4225725743 cites W2056134733 @default.
- W4225725743 cites W2061365505 @default.
- W4225725743 cites W2062930664 @default.
- W4225725743 cites W2063009130 @default.
- W4225725743 cites W2065147071 @default.
- W4225725743 cites W2065462174 @default.
- W4225725743 cites W2070691522 @default.
- W4225725743 cites W2071273298 @default.
- W4225725743 cites W2071450296 @default.
- W4225725743 cites W2073455422 @default.
- W4225725743 cites W2074046926 @default.
- W4225725743 cites W2080105605 @default.
- W4225725743 cites W2083981417 @default.
- W4225725743 cites W2086241020 @default.
- W4225725743 cites W2087717115 @default.
- W4225725743 cites W2088256169 @default.
- W4225725743 cites W2088781465 @default.
- W4225725743 cites W2092488476 @default.
- W4225725743 cites W2093776293 @default.
- W4225725743 cites W2094665977 @default.
- W4225725743 cites W2096129454 @default.
- W4225725743 cites W2096828108 @default.
- W4225725743 cites W2099579483 @default.
- W4225725743 cites W2100311096 @default.
- W4225725743 cites W2109541361 @default.
- W4225725743 cites W2115289235 @default.
- W4225725743 cites W2117139515 @default.
- W4225725743 cites W2120656648 @default.