FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225727263> ?p ?o ?g. }

• W4225727263 abstract "Autologous stem cell transplantation (ASCT) is an established therapy for many hematological diseases. This study assessed the pattern of ASCTs at a tertiary care center and associated factors, including pre-harvest CD34+ stem cell levels, leading to improved engraftment outcomes.A retrospective study was conducted in India, between February 2009-August 2020. Patients who underwent ASCT for different hematological malignancies (n=65) were included, and the patients' age, sex, type and stage of disease, pre- and post-harvest CD34+ counts, and time to attain platelet/neutrophil engraftment or febrile neutropenia were analyzed. The post-harvest CD34+ dose was calculated. Pre-conditioning was performed using Granulocyte Colony Stimulating Factor (GCSF)±Plerixafor. Progression-free survival (PFS) was calculated using relapse/death as the endpoint.The median age of the cohort (n=65) was 49 years, with a male preponderance. Multiple myeloma was the most common malignancy (70.8% [46/65]), requiring ASCT. The median time to ASCT was 13 months. All patients had received GCSF, while Plerixafor was used in 17 patients with a pre-harvest CD34+ count of <10 cells/μL. The median pre-harvest CD34+ concentration and post-harvest CD34+ cell dose was 27.54 cells/μL (n=26) and 5.23×106 cells/kg body weight (n=65), respectively. The median time to engraftment was 11 and 12 days, for neutrophils and platelets, respectively. One patient did not engraft and was excluded from the analysis. The time required to attain neutrophil engraftment was significantly lower (p=0.02) among freshly harvested stem cells (n=48) than that of cryopreserved products (n=17). Platelet engraftment associated with CD34+ pre- and post-harvest levels was not significant (p=0.06). The time to attain neutropenia and subsequent febrile neutropenia was significantly lower with an adequate post-harvest CD34+ dose (p=0.009). Febrile neutropenia was seen in 83.1% (54/65) patients. The median time for febrile neutropenia was 4 days post-ASCT. Pre- and post-harvest CD34+ concentrations were directly proportional to each other (p<0.001). The median PFS was 112 months (n=65). Survival was better in males (median PFS: 112 months) vs. females (median PFS: 59 months) (p=0.27). Eight patients relapsed, and eight patients had died.Although unrelated to age or sex, the post-harvest CD34+ dose was inversely related to febrile neutropenia. As pre- and post-harvest CD34+ levels were directly proportional, pre-harvest CD34+ concentrations may be reliably used to assess engraftment outcomes. Rapid neutrophil engraftment was noted in fresh stem cells with PFS of 112 months, and was better among males, the exact reason being unknown. Thus, a larger number of patients should be followed up to obtain an accurate picture." @default.
• W4225727263 created "2022-05-05" @default.
• W4225727263 creator A5001796977 @default.
• W4225727263 creator A5032402858 @default.
• W4225727263 creator A5032886035 @default.
• W4225727263 creator A5045837832 @default.
• W4225727263 creator A5046429882 @default.
• W4225727263 creator A5047899027 @default.
• W4225727263 creator A5055708314 @default.
• W4225727263 creator A5060847272 @default.
• W4225727263 creator A5070415173 @default.
• W4225727263 creator A5086114700 @default.
• W4225727263 creator A5091686090 @default.
• W4225727263 date "2022-01-01" @default.
• W4225727263 modified "2023-10-14" @default.
• W4225727263 title "Pattern of autologous stem cell transplants at a tertiary care government hospital, with emphasis on transplant outcomes with pre-harvest CD34+ level" @default.
• W4225727263 cites W1158218703 @default.
• W4225727263 cites W1532162953 @default.
• W4225727263 cites W1805804819 @default.
• W4225727263 cites W1984166296 @default.
• W4225727263 cites W1987610068 @default.
• W4225727263 cites W1988068150 @default.
• W4225727263 cites W1996320020 @default.
• W4225727263 cites W2010071686 @default.
• W4225727263 cites W2010365172 @default.
• W4225727263 cites W2054771846 @default.
• W4225727263 cites W2064378168 @default.
• W4225727263 cites W2098921577 @default.
• W4225727263 cites W2115266573 @default.
• W4225727263 cites W2136161953 @default.
• W4225727263 cites W2149502955 @default.
• W4225727263 cites W2154615874 @default.
• W4225727263 cites W2169721813 @default.
• W4225727263 cites W2248611751 @default.
• W4225727263 cites W2382216665 @default.
• W4225727263 cites W2383338988 @default.
• W4225727263 cites W2518085824 @default.
• W4225727263 cites W2621741324 @default.
• W4225727263 cites W2775695736 @default.
• W4225727263 cites W2782906623 @default.
• W4225727263 cites W2810362089 @default.
• W4225727263 cites W2915049818 @default.
• W4225727263 cites W2915646204 @default.
• W4225727263 cites W2979631845 @default.
• W4225727263 cites W3034037943 @default.
• W4225727263 doi "https://doi.org/10.31547/bct-2021-010" @default.
• W4225727263 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36714265" @default.
• W4225727263 hasPublicationYear "2022" @default.
• W4225727263 type Work @default.
• W4225727263 citedByCount "0" @default.
• W4225727263 crossrefType "journal-article" @default.
• W4225727263 hasAuthorship W4225727263A5001796977 @default.
• W4225727263 hasAuthorship W4225727263A5032402858 @default.
• W4225727263 hasAuthorship W4225727263A5032886035 @default.
• W4225727263 hasAuthorship W4225727263A5045837832 @default.
• W4225727263 hasAuthorship W4225727263A5046429882 @default.
• W4225727263 hasAuthorship W4225727263A5047899027 @default.
• W4225727263 hasAuthorship W4225727263A5055708314 @default.
• W4225727263 hasAuthorship W4225727263A5060847272 @default.
• W4225727263 hasAuthorship W4225727263A5070415173 @default.
• W4225727263 hasAuthorship W4225727263A5086114700 @default.
• W4225727263 hasAuthorship W4225727263A5091686090 @default.
• W4225727263 hasBestOaLocation W42257272631 @default.
• W4225727263 hasConcept C10205521 @default.
• W4225727263 hasConcept C126322002 @default.
• W4225727263 hasConcept C129470790 @default.
• W4225727263 hasConcept C13373296 @default.
• W4225727263 hasConcept C141071460 @default.
• W4225727263 hasConcept C170493617 @default.
• W4225727263 hasConcept C2776364478 @default.
• W4225727263 hasConcept C2776694085 @default.
• W4225727263 hasConcept C2777063308 @default.
• W4225727263 hasConcept C2777767877 @default.
• W4225727263 hasConcept C2778828106 @default.
• W4225727263 hasConcept C2779050716 @default.
• W4225727263 hasConcept C28328180 @default.
• W4225727263 hasConcept C2911091166 @default.
• W4225727263 hasConcept C54355233 @default.
• W4225727263 hasConcept C71924100 @default.
• W4225727263 hasConcept C74133956 @default.
• W4225727263 hasConcept C86803240 @default.
• W4225727263 hasConceptScore W4225727263C10205521 @default.
• W4225727263 hasConceptScore W4225727263C126322002 @default.
• W4225727263 hasConceptScore W4225727263C129470790 @default.
• W4225727263 hasConceptScore W4225727263C13373296 @default.
• W4225727263 hasConceptScore W4225727263C141071460 @default.
• W4225727263 hasConceptScore W4225727263C170493617 @default.
• W4225727263 hasConceptScore W4225727263C2776364478 @default.
• W4225727263 hasConceptScore W4225727263C2776694085 @default.
• W4225727263 hasConceptScore W4225727263C2777063308 @default.
• W4225727263 hasConceptScore W4225727263C2777767877 @default.
• W4225727263 hasConceptScore W4225727263C2778828106 @default.
• W4225727263 hasConceptScore W4225727263C2779050716 @default.
• W4225727263 hasConceptScore W4225727263C28328180 @default.
• W4225727263 hasConceptScore W4225727263C2911091166 @default.
• W4225727263 hasConceptScore W4225727263C54355233 @default.
• W4225727263 hasConceptScore W4225727263C71924100 @default.
• W4225727263 hasConceptScore W4225727263C74133956 @default.
• W4225727263 hasConceptScore W4225727263C86803240 @default.
• W4225727263 hasIssue "1" @default.

• next