FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225738788> ?p ?o ?g. }

• W4225738788 endingPage "895" @default.
• W4225738788 startingPage "887" @default.
• W4225738788 abstract "Abstract Objective We investigated the metabolic changes in pancreatic ductal adenocarcinoma to identify the mechanisms of treatment response of neoadjuvant chemoradiation therapy. Methods Frozen tumor and non-neoplastic pancreas tissues were prospectively obtained from 88 patients with pancreatic ductal adenocarcinoma who underwent curative-intent surgery. Sixty-two patients received neoadjuvant chemoradiation therapy and 26 patients did not receive neoadjuvant therapy (control group). Comprehensive analysis of metabolites in tumor and non-neoplastic pancreatic tissue was performed by capillary electrophoresis-mass spectrometry. Results Capillary electrophoresis-mass spectrometry detected 90 metabolites for analysis among more than 500 ionic metabolites quantified. There were significant differences in 27 tumor metabolites between the neoadjuvant chemoradiation therapy and control groups. There were significant differences in eight metabolites [1-MethylnNicotinamide, Carnitine, Glucose, Glutathione (red), N-acetylglucosamine 6-phosphate, N-acetylglucosamine 1-phosphate, UMP, Phosphocholine] between good responder and poor responder for neoadjuvant chemoradiation therapy. Among these metabolites, phosphocholine, Carnitine and Glutathione were associated with recurrence-free survival only in the neoadjuvant chemoradiation therapy group. Microarray confirmed marked gene suppression of choline transporters [CTL1-4 (SLC44A1-44A4)] in pancreatic ductal adenocarcinoma tissue of neoadjuvant chemoradiation therapy group. Conclusion The present study identifies several important metabolic consequences and potential neoadjuvant chemoradiation therapy targets in pancreatic ductal adenocarcinoma. Choline metabolism is one of the key pathways involved in recurrence of the patients with pancreatic ductal adenocarcinoma who received neoadjuvant chemoradiation therapy." @default.
• W4225738788 created "2022-05-05" @default.
• W4225738788 creator A5004387926 @default.
• W4225738788 creator A5007240978 @default.
• W4225738788 creator A5017666745 @default.
• W4225738788 creator A5017931660 @default.
• W4225738788 creator A5018382490 @default.
• W4225738788 creator A5025984729 @default.
• W4225738788 creator A5038138665 @default.
• W4225738788 creator A5041602945 @default.
• W4225738788 creator A5044755346 @default.
• W4225738788 creator A5044938272 @default.
• W4225738788 creator A5045666187 @default.
• W4225738788 creator A5049122521 @default.
• W4225738788 creator A5056637524 @default.
• W4225738788 creator A5061501935 @default.
• W4225738788 creator A5072237903 @default.
• W4225738788 creator A5073825678 @default.
• W4225738788 creator A5081010938 @default.
• W4225738788 creator A5085278426 @default.
• W4225738788 creator A5087195765 @default.
• W4225738788 date "2022-05-06" @default.
• W4225738788 modified "2023-10-14" @default.
• W4225738788 title "Tumor metabolic alterations after neoadjuvant chemoradiotherapy predict postoperative recurrence in patients with pancreatic cancer" @default.
• W4225738788 cites W1522874790 @default.
• W4225738788 cites W1910910895 @default.
• W4225738788 cites W1964820180 @default.
• W4225738788 cites W1967956133 @default.
• W4225738788 cites W2020058751 @default.
• W4225738788 cites W2041399911 @default.
• W4225738788 cites W2072451938 @default.
• W4225738788 cites W2077003423 @default.
• W4225738788 cites W2083166156 @default.
• W4225738788 cites W2087593234 @default.
• W4225738788 cites W2128634317 @default.
• W4225738788 cites W2149212516 @default.
• W4225738788 cites W2156233892 @default.
• W4225738788 cites W2223535266 @default.
• W4225738788 cites W2395626624 @default.
• W4225738788 cites W2399064224 @default.
• W4225738788 cites W2412717755 @default.
• W4225738788 cites W2513596443 @default.
• W4225738788 cites W2519942994 @default.
• W4225738788 cites W2578297329 @default.
• W4225738788 cites W2593338845 @default.
• W4225738788 cites W2593627366 @default.
• W4225738788 cites W2604473882 @default.
• W4225738788 cites W2624783949 @default.
• W4225738788 cites W2749296525 @default.
• W4225738788 cites W2766375979 @default.
• W4225738788 cites W2768787369 @default.
• W4225738788 cites W2791549657 @default.
• W4225738788 cites W2912196744 @default.
• W4225738788 doi "https://doi.org/10.1093/jjco/hyac074" @default.
• W4225738788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35523689" @default.
• W4225738788 hasPublicationYear "2022" @default.
• W4225738788 type Work @default.
• W4225738788 citedByCount "3" @default.
• W4225738788 countsByYear W42257387882023 @default.
• W4225738788 crossrefType "journal-article" @default.
• W4225738788 hasAuthorship W4225738788A5004387926 @default.
• W4225738788 hasAuthorship W4225738788A5007240978 @default.
• W4225738788 hasAuthorship W4225738788A5017666745 @default.
• W4225738788 hasAuthorship W4225738788A5017931660 @default.
• W4225738788 hasAuthorship W4225738788A5018382490 @default.
• W4225738788 hasAuthorship W4225738788A5025984729 @default.
• W4225738788 hasAuthorship W4225738788A5038138665 @default.
• W4225738788 hasAuthorship W4225738788A5041602945 @default.
• W4225738788 hasAuthorship W4225738788A5044755346 @default.
• W4225738788 hasAuthorship W4225738788A5044938272 @default.
• W4225738788 hasAuthorship W4225738788A5045666187 @default.
• W4225738788 hasAuthorship W4225738788A5049122521 @default.
• W4225738788 hasAuthorship W4225738788A5056637524 @default.
• W4225738788 hasAuthorship W4225738788A5061501935 @default.
• W4225738788 hasAuthorship W4225738788A5072237903 @default.
• W4225738788 hasAuthorship W4225738788A5073825678 @default.
• W4225738788 hasAuthorship W4225738788A5081010938 @default.
• W4225738788 hasAuthorship W4225738788A5085278426 @default.
• W4225738788 hasAuthorship W4225738788A5087195765 @default.
• W4225738788 hasBestOaLocation W42257387881 @default.
• W4225738788 hasConcept C121608353 @default.
• W4225738788 hasConcept C126322002 @default.
• W4225738788 hasConcept C143998085 @default.
• W4225738788 hasConcept C2778292576 @default.
• W4225738788 hasConcept C2778764654 @default.
• W4225738788 hasConcept C2780210213 @default.
• W4225738788 hasConcept C2781182431 @default.
• W4225738788 hasConcept C530470458 @default.
• W4225738788 hasConcept C71924100 @default.
• W4225738788 hasConceptScore W4225738788C121608353 @default.
• W4225738788 hasConceptScore W4225738788C126322002 @default.
• W4225738788 hasConceptScore W4225738788C143998085 @default.
• W4225738788 hasConceptScore W4225738788C2778292576 @default.
• W4225738788 hasConceptScore W4225738788C2778764654 @default.
• W4225738788 hasConceptScore W4225738788C2780210213 @default.
• W4225738788 hasConceptScore W4225738788C2781182431 @default.
• W4225738788 hasConceptScore W4225738788C530470458 @default.
• W4225738788 hasConceptScore W4225738788C71924100 @default.

• next