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• W4225746162 abstract "Objective: This study aimed to determine whether the apparent diffusion coefficients (ADCs) determined by diffusion-weighted imaging (DWI) of magnetic resonance imaging (MRI) could facilitate the malignancy grading of various gliomas. Methods: Sixty patients with a primary cerebral glioma underwent diffusion-weighted and gadolinium-enhanced (Gd) T1-weighted MRI using a 1.5-T MRI scanner. Scoring was performed based on signal intensities on DWI and Gd images. The mean and minimum ADC values were calculated, and Ki-67 staining was performed for each histological sample to evaluate their tumor proliferative potential. Then, the DWI, Gd, and combined scores were analyzed and compared with the Ki-67 staining index and malignant grade. The relationships among the mean and minimum ADC values, Ki-67 staining index, and malignant grade were also evaluated. Results: The minimum ADC was inversely correlated with the Ki-67 staining index, with a low minimum ADC suggestive of tumor malignancy. The qualitative evaluation of the D score of water molecule diffusion on DWI accurately reflected the pathological grades of gliomas, with an effectiveness that was at least as good as the quantitative analysis using the minimum ADC. The diagnostic value of Gd images in determining glioma malignancy grades was inferior to that of DWI. Conclusion: Both DWI and gadolinium-enhanced images of MRI should be considered essential for the diagnosis of tumor malignancy." @default.
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• W4225746162 date "2021-12-01" @default.
• W4225746162 modified "2023-10-18" @default.
• W4225746162 title "Evaluation of the malignant potential of gliomas using diffusion-weighted and gadolinium-enhanced magnetic resonance imaging" @default.
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• W4225746162 doi "https://doi.org/10.26599/bsa.2021.9050023" @default.
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