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- W4225753310 abstract "The positive transcription elongation factor b (P-TEFb) is a critical coactivator for transcription of most cellular and viral genes, including those of HIV. While P-TEFb is regulated by 7SK snRNA in proliferating cells, P-TEFb is absent due to diminished levels of CycT1 in quiescent and terminally differentiated cells, which has remained unexplored. In these cells, we found that CycT1 not bound to CDK9 is rapidly degraded. Moreover, productive CycT1:CDK9 interactions are increased by PKC-mediated phosphorylation of CycT1 in human cells. Conversely, dephosphorylation of CycT1 by PP1 reverses this process. Thus, PKC inhibitors or removal of PKC by chronic activation results in P-TEFb disassembly and CycT1 degradation. This finding not only recapitulates P-TEFb depletion in resting CD4+ T cells but also in anergic T cells. Importantly, our studies reveal mechanisms of P-TEFb inactivation underlying T cell quiescence, anergy, and exhaustion as well as proviral latency and terminally differentiated cells." @default.
- W4225753310 created "2022-05-05" @default.
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- W4225753310 date "2021-11-25" @default.
- W4225753310 modified "2023-10-18" @default.
- W4225753310 title "Reversible phosphorylation of cyclin T1 promotes assembly and stability of P-TEFb" @default.
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- W4225753310 cites W1968118598 @default.
- W4225753310 cites W1968984443 @default.
- W4225753310 cites W1973000551 @default.
- W4225753310 cites W1976499671 @default.
- W4225753310 cites W1983228426 @default.
- W4225753310 cites W1983546572 @default.
- W4225753310 cites W1989039704 @default.
- W4225753310 cites W1991749307 @default.
- W4225753310 cites W1995110654 @default.
- W4225753310 cites W2003715268 @default.
- W4225753310 cites W2035711293 @default.
- W4225753310 cites W2041532798 @default.
- W4225753310 cites W2046854154 @default.
- W4225753310 cites W2055802474 @default.
- W4225753310 cites W2057228860 @default.
- W4225753310 cites W2058565051 @default.
- W4225753310 cites W2060143438 @default.
- W4225753310 cites W2075670261 @default.
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- W4225753310 cites W2112141228 @default.
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- W4225753310 cites W2118233996 @default.
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- W4225753310 cites W2122466812 @default.
- W4225753310 cites W2127284613 @default.
- W4225753310 cites W2128705810 @default.
- W4225753310 cites W2132629607 @default.
- W4225753310 cites W2135229538 @default.
- W4225753310 cites W2135736528 @default.
- W4225753310 cites W2142868265 @default.
- W4225753310 cites W2148917483 @default.
- W4225753310 cites W2151375318 @default.
- W4225753310 cites W2155212300 @default.
- W4225753310 cites W2155603822 @default.
- W4225753310 cites W2157910557 @default.
- W4225753310 cites W2162082053 @default.
- W4225753310 cites W2162914583 @default.
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- W4225753310 cites W2313116527 @default.
- W4225753310 cites W2319148284 @default.
- W4225753310 cites W2322237813 @default.
- W4225753310 cites W2416819443 @default.
- W4225753310 cites W2467821849 @default.
- W4225753310 cites W2494243053 @default.
- W4225753310 cites W2522058963 @default.
- W4225753310 cites W2592937467 @default.
- W4225753310 cites W2613119007 @default.
- W4225753310 cites W2738102269 @default.
- W4225753310 cites W2788334321 @default.
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- W4225753310 doi "https://doi.org/10.7554/elife.68473" @default.
- W4225753310 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34821217" @default.
- W4225753310 hasPublicationYear "2021" @default.
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