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- W4225753721 abstract "Immunotherapies targeting immune checkpoint molecules have shown promising treatment for a subset of cancers; however, many cold tumors, such as prostate cancer, remain unresponsive. We aimed to identify a potential targetable marker relevant to prostate cancer and develop novel immunotherapy.Analysis of transcriptomic profiles at single-cell resolution was performed in clinical patients' samples, along with integrated analysis of multiple RNA-sequencing datasets. The antitumor activity of YY001, a novel EP4 antagonist, combined with anti-programmed cell death protein 1 (PD-1) antibody was evaluated both in vitro and in vivo.We identified EP4 (PTGER4) as expressed in epithelial cells and various immune cells and involved in modulating the prostate cancer immune microenvironment. YY001, a novel EP4 antagonist, inhibited the differentiation, maturation, and immunosuppressive function of myeloid-derived suppressor cells (MDSC) while enhancing the proliferation and anticancer functions of T cells. Furthermore, it reversed the infiltration levels of MDSCs and T cells in the tumor microenvironment by overturning the chemokine profile of tumor cells in vitro and in vivo. The combined immunotherapy demonstrated a robust antitumor immune response as indicated by the robust accumulation and activation of CD8+ cytotoxic T cells, with a significantly decreased MDSC ratio and reduced MDSC immunosuppression function.Our study identified EP4 as a specific target for prostate cancer immunotherapy and demonstrated that YY001 inhibited the growth of prostate tumors by regulating the immune microenvironment and strongly synergized with anti-PD-1 antibodies to convert completely unresponsive prostate cancers into responsive cancers, resulting in marked tumor regression, long-term survival, and lasting immunologic memory." @default.
- W4225753721 created "2022-05-05" @default.
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- W4225753721 date "2022-02-01" @default.
- W4225753721 modified "2023-10-12" @default.
- W4225753721 title "Single-Cell Analysis Reveals EP4 as a Target for Restoring T-Cell Infiltration and Sensitizing Prostate Cancer to Immunotherapy" @default.
- W4225753721 cites W1582446028 @default.
- W4225753721 cites W1983754832 @default.
- W4225753721 cites W1991235944 @default.
- W4225753721 cites W1996097278 @default.
- W4225753721 cites W2004150448 @default.
- W4225753721 cites W2019799131 @default.
- W4225753721 cites W2031756196 @default.
- W4225753721 cites W2035338709 @default.
- W4225753721 cites W2036564412 @default.
- W4225753721 cites W2039146285 @default.
- W4225753721 cites W2059586354 @default.
- W4225753721 cites W2060672294 @default.
- W4225753721 cites W2063192133 @default.
- W4225753721 cites W2075183972 @default.
- W4225753721 cites W2075371342 @default.
- W4225753721 cites W2083670478 @default.
- W4225753721 cites W2090928408 @default.
- W4225753721 cites W2108337681 @default.
- W4225753721 cites W2124473498 @default.
- W4225753721 cites W2134069241 @default.
- W4225753721 cites W2151014103 @default.
- W4225753721 cites W2152588224 @default.
- W4225753721 cites W2156675849 @default.
- W4225753721 cites W2158778756 @default.
- W4225753721 cites W2158960911 @default.
- W4225753721 cites W2160834915 @default.
- W4225753721 cites W2162085901 @default.
- W4225753721 cites W2162222767 @default.
- W4225753721 cites W2168066532 @default.
- W4225753721 cites W2168242827 @default.
- W4225753721 cites W2180120860 @default.
- W4225753721 cites W2206971126 @default.
- W4225753721 cites W2461513545 @default.
- W4225753721 cites W2531934133 @default.
- W4225753721 cites W2595314544 @default.
- W4225753721 cites W2624831627 @default.
- W4225753721 cites W2727513755 @default.
- W4225753721 cites W2737082469 @default.
- W4225753721 cites W2741796350 @default.
- W4225753721 cites W2766100101 @default.
- W4225753721 cites W2769704777 @default.
- W4225753721 cites W2790597879 @default.
- W4225753721 cites W2808837841 @default.
- W4225753721 cites W2810097927 @default.
- W4225753721 cites W2838357484 @default.
- W4225753721 cites W2886498337 @default.
- W4225753721 cites W2889646458 @default.
- W4225753721 cites W2908581980 @default.
- W4225753721 cites W2935069581 @default.
- W4225753721 cites W2947497798 @default.
- W4225753721 cites W2947747865 @default.
- W4225753721 cites W2955530789 @default.
- W4225753721 cites W2978046321 @default.
- W4225753721 cites W2994938720 @default.
- W4225753721 cites W3016360824 @default.
- W4225753721 cites W3029206054 @default.
- W4225753721 cites W3032405266 @default.
- W4225753721 cites W3036762572 @default.
- W4225753721 cites W3105880108 @default.
- W4225753721 cites W3115800286 @default.
- W4225753721 cites W3120827191 @default.
- W4225753721 cites W3134655285 @default.
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- W4225753721 doi "https://doi.org/10.1158/1078-0432.ccr-21-0299" @default.
- W4225753721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34740924" @default.
- W4225753721 hasPublicationYear "2022" @default.