FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225786140> ?p ?o ?g. }

• W4225786140 endingPage "1641" @default.
• W4225786140 startingPage "1619" @default.
• W4225786140 abstract "Is there an association between the different endometrial preparation protocols for frozen embryo transfer (FET) and obstetric and perinatal outcomes?Programmed FET protocols were associated with a significantly higher risk of hypertensive disorders of pregnancy (HDP), pre-eclampsia (PE), post-partum hemorrhage (PPH) and cesarean section (CS) when compared with natural FET protocols.An important and growing source of concern regarding the use of FET on a wide spectrum of women, is represented by its association with obstetric and perinatal complications. However, reasons behind these increased risks are still unknown and understudied.Systematic review with meta-analysis. We systematically searched PubMed, MEDLINE, Embase and Scopus, from database inception to 1 November 2021. Published randomized controlled trials, cohort and case control studies were all eligible for inclusion. The risk of bias was assessed using the Newcastle-Ottawa Quality Assessment Scale. The quality of evidence was also evaluated using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach.Studies were included only if investigators reported obstetric and/or perinatal outcomes for at least two of the following endometrial preparation protocols: programmed FET cycle (PC-FET) (i.e. treatment with hormone replacement therapy (HRT)); total natural FET cycle (tNC-FET); modified natural FET cycle (mNC-FET); stimulated FET cycle (SC-FET).Pooled results showed a higher risk of HDP (12 studies, odds ratio (OR) 1.90; 95% CI 1.64-2.20; P < 0.00001; I2 = 50%) (very low quality), pregnancy-induced hypertension (5 studies, OR 1.46; 95% CI 1.03-2.07; P = 0.03; I2 = 0%) (very low quality), PE (8 studies, OR 2.11; 95% CI 1.87-2.39; P < 0.00001; I2 = 29%) (low quality), placenta previa (10 studies, OR 1.27; 95% CI 1.05-1.54; P = 0.01; I2 = 8%) (very low quality), PPH (6 studies, OR 2.53; 95% CI 2.19-2.93; P < 0.00001; I2 = 0%) (low quality), CS (12 studies, OR 1.62; 95% CI 1.53-1.71; P < 0.00001; I2 = 48%) (very low quality), preterm birth (15 studies, OR 1.19; 95% CI 1.09-1.29; P < 0.0001; I2 = 47%) (very low quality), very preterm birth (7 studies, OR 1.63; 95% CI 1.23-2.15; P = 0.0006; I2 = 21%) (very low quality), placenta accreta (2 studies, OR 6.29; 95% CI 2.75-14.40; P < 0.0001; I2 = 0%) (very low quality), preterm premature rupture of membranes (3 studies, OR 1.84; 95% CI 0.82-4.11; P = 0.14; I2 = 61%) (very low quality), post-term birth (OR 1.90; 95% CI 1.25-2.90; P = 0.003; I2 = 73%) (very low quality), macrosomia (10 studies, OR 1.18; 95% CI 1.05-1.32; P = 0.007; I2 = 45%) (very low quality) and large for gestational age (LGA) (14 studies, OR 1.08; 95% CI 1.01-1.16; P = 0.02; I2 = 50%) (very low quality), in PC-FET pregnancies when compared with NC (tNC + mNC)-FET pregnancies. However, after pooling of ORs adjusted for the possible confounding variables, the endometrial preparation by HRT maintained a significant association in all sub-analyses exclusively with HDP, PE, PPH (low quality) and CS (very low quality).The principal limitation concerns the heterogeneity across studies in: (i) timing and dosage of HRT; (ii) embryo stage at transfer; and (iii) inclusion of preimplantation genetic testing cycles. To address it, we undertook subgroup analyses by pooling only ORs adjusted for a specific possible confounding factor.Endometrial preparation protocols with HRT were associated with worse obstetric and perinatal outcomes. However, because of the methodological weaknesses, recommendations for clinical practice cannot be made. Well conducted prospective studies are thus warranted to establish a safe endometrial preparation strategy for FET cycles aimed at limiting superimposed risks in women with an 'a priori' high-risk profile for obstetric and perinatal complications.None.CRD42021249927." @default.
• W4225786140 created "2022-05-05" @default.
• W4225786140 creator A5036017087 @default.
• W4225786140 creator A5037954837 @default.
• W4225786140 date "2022-05-13" @default.
• W4225786140 modified "2023-10-06" @default.
• W4225786140 title "Obstetric and perinatal outcomes following programmed compared to natural frozen-thawed embryo transfer cycles: a systematic review and meta-analysis" @default.
• W4225786140 cites W1247968195 @default.
• W4225786140 cites W186268426 @default.
• W4225786140 cites W1967046314 @default.
• W4225786140 cites W2091849572 @default.
• W4225786140 cites W2101442434 @default.
• W4225786140 cites W2468996569 @default.
• W4225786140 cites W2471041811 @default.
• W4225786140 cites W2575181247 @default.
• W4225786140 cites W2768946593 @default.
• W4225786140 cites W2810656455 @default.
• W4225786140 cites W2890815650 @default.
• W4225786140 cites W2896073914 @default.
• W4225786140 cites W2903585683 @default.
• W4225786140 cites W2909079157 @default.
• W4225786140 cites W2915876315 @default.
• W4225786140 cites W2916530067 @default.
• W4225786140 cites W2923104520 @default.
• W4225786140 cites W2925859572 @default.
• W4225786140 cites W2959031195 @default.
• W4225786140 cites W2962732120 @default.
• W4225786140 cites W2977714750 @default.
• W4225786140 cites W2997807561 @default.
• W4225786140 cites W3006907233 @default.
• W4225786140 cites W3009610597 @default.
• W4225786140 cites W3011599618 @default.
• W4225786140 cites W3015739340 @default.
• W4225786140 cites W3022162501 @default.
• W4225786140 cites W3032736632 @default.
• W4225786140 cites W3037549087 @default.
• W4225786140 cites W3042661563 @default.
• W4225786140 cites W3043324389 @default.
• W4225786140 cites W3081701667 @default.
• W4225786140 cites W3082225452 @default.
• W4225786140 cites W3084851529 @default.
• W4225786140 cites W3090790429 @default.
• W4225786140 cites W3112157728 @default.
• W4225786140 cites W3118601047 @default.
• W4225786140 cites W3121006341 @default.
• W4225786140 cites W3124458597 @default.
• W4225786140 cites W3128117756 @default.
• W4225786140 cites W3134586164 @default.
• W4225786140 cites W3157775770 @default.
• W4225786140 cites W3183236358 @default.
• W4225786140 doi "https://doi.org/10.1093/humrep/deac073" @default.
• W4225786140 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35553678" @default.
• W4225786140 hasPublicationYear "2022" @default.
• W4225786140 type Work @default.
• W4225786140 citedByCount "25" @default.
• W4225786140 countsByYear W42257861402022 @default.
• W4225786140 countsByYear W42257861402023 @default.
• W4225786140 crossrefType "journal-article" @default.
• W4225786140 hasAuthorship W4225786140A5036017087 @default.
• W4225786140 hasAuthorship W4225786140A5037954837 @default.
• W4225786140 hasConcept C126322002 @default.
• W4225786140 hasConcept C131872663 @default.
• W4225786140 hasConcept C156957248 @default.
• W4225786140 hasConcept C160099875 @default.
• W4225786140 hasConcept C168563851 @default.
• W4225786140 hasConcept C201903717 @default.
• W4225786140 hasConcept C2779234561 @default.
• W4225786140 hasConcept C29456083 @default.
• W4225786140 hasConcept C54355233 @default.
• W4225786140 hasConcept C71924100 @default.
• W4225786140 hasConcept C86803240 @default.
• W4225786140 hasConcept C95190672 @default.
• W4225786140 hasConceptScore W4225786140C126322002 @default.
• W4225786140 hasConceptScore W4225786140C131872663 @default.
• W4225786140 hasConceptScore W4225786140C156957248 @default.
• W4225786140 hasConceptScore W4225786140C160099875 @default.
• W4225786140 hasConceptScore W4225786140C168563851 @default.
• W4225786140 hasConceptScore W4225786140C201903717 @default.
• W4225786140 hasConceptScore W4225786140C2779234561 @default.
• W4225786140 hasConceptScore W4225786140C29456083 @default.
• W4225786140 hasConceptScore W4225786140C54355233 @default.
• W4225786140 hasConceptScore W4225786140C71924100 @default.
• W4225786140 hasConceptScore W4225786140C86803240 @default.
• W4225786140 hasConceptScore W4225786140C95190672 @default.
• W4225786140 hasIssue "7" @default.
• W4225786140 hasLocation W42257861401 @default.
• W4225786140 hasLocation W42257861402 @default.
• W4225786140 hasOpenAccess W4225786140 @default.
• W4225786140 hasPrimaryLocation W42257861401 @default.
• W4225786140 hasRelatedWork W2018450738 @default.
• W4225786140 hasRelatedWork W2286371484 @default.
• W4225786140 hasRelatedWork W2566619692 @default.
• W4225786140 hasRelatedWork W3087588175 @default.
• W4225786140 hasRelatedWork W3094705713 @default.
• W4225786140 hasRelatedWork W3159250744 @default.
• W4225786140 hasRelatedWork W4256514411 @default.
• W4225786140 hasRelatedWork W4292236216 @default.
• W4225786140 hasRelatedWork W4310244857 @default.

• next