FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225792065> ?p ?o ?g. }

• W4225792065 endingPage "i295" @default.
• W4225792065 startingPage "i294" @default.
• W4225792065 abstract "Abstract Background Calprotectin is a small calcium-binding protein that when measured in human stool has shown utility in assessing the degree of bowel inflammation in inflammatory bowel disease (IBD) and in distinguishing IBD from irritable bowel syndrome (IBS). However, most fecal calprotectin (FCP) assays are slow and inconvenient. This study examined the analytical agreement and clinical utility of a point of care (POC) assay for FCP. Methods A fast (~5 min.), time-resolved fluorescence resonance energy transfer based immunoassay (Procise FCP™) was developed for the POC measurement of FCP using 15 mg of fecal specimen eluted in collection fluid from the Procise Stool Collection Device™. The analytical agreement between the Procise FCP assay and a commercial ELISA assay: Inova Quanta Lite Calprotectin Extended Range was assessed using 46 leftover deidentified fecal specimens. Clinical performance of the assay was assessed using stored frozen stool specimens from a nested cohort derived from a prospective study of chronic diarrhea patients. Chronic diarrhea was defined as unexplained diarrhea of at least 4 weeks duration. Study subjects were males and females of ages 2 – 70 with no chronic liver disease and were consecutively enrolled. Diagnoses were made by attending physicians, and IBD patients did not necessarily have active disease beyond diarrhea at the time of specimen collection. Primary endpoint: Proportion of patients diagnosed with either IBS or IBD testing positive for FCP. Statistical analysis Method comparison analysis was performed by Deming linear regression. A post hoc analysis of patients from the diarrhea study diagnosed with either IBS or IBD was performed. The significance of the proportion of patients diagnosed with either IBS or IBD testing positive for FCP was calculated using Fisher’s Exact Probability Test. The assay was assessed at cut-offs of 50 µg/g and 120 µg/g. Results Figure 1. Table 1. Table 2. Conclusion The Procise FCP assay shows excellent analytical agreement to another commercial FCP assay and can clinically significantly distinguish between IBD and IBS in chronic diarrhea patients. Thus, the assay can aid in the differentiation of IBD from IBS. Distinguishing IBS from IBD with a convenient POC format test enhances the clinical utility of FCP by enabling faster treatment response" @default.
• W4225792065 created "2022-05-05" @default.
• W4225792065 creator A5006395460 @default.
• W4225792065 creator A5023280555 @default.
• W4225792065 creator A5039792217 @default.
• W4225792065 creator A5051950804 @default.
• W4225792065 creator A5055083846 @default.
• W4225792065 creator A5059082657 @default.
• W4225792065 creator A5066116325 @default.
• W4225792065 creator A5066881525 @default.
• W4225792065 creator A5081931838 @default.
• W4225792065 creator A5085604066 @default.
• W4225792065 date "2022-01-01" @default.
• W4225792065 modified "2023-09-25" @default.
• W4225792065 title "P250 Clinical validation of a point of care test for fecal calprotectin in distinguishing irritable bowel syndrome from Inflammatory Bowel Disease" @default.
• W4225792065 doi "https://doi.org/10.1093/ecco-jcc/jjab232.377" @default.
• W4225792065 hasPublicationYear "2022" @default.
• W4225792065 type Work @default.
• W4225792065 citedByCount "0" @default.
• W4225792065 crossrefType "journal-article" @default.
• W4225792065 hasAuthorship W4225792065A5006395460 @default.
• W4225792065 hasAuthorship W4225792065A5023280555 @default.
• W4225792065 hasAuthorship W4225792065A5039792217 @default.
• W4225792065 hasAuthorship W4225792065A5051950804 @default.
• W4225792065 hasAuthorship W4225792065A5055083846 @default.
• W4225792065 hasAuthorship W4225792065A5059082657 @default.
• W4225792065 hasAuthorship W4225792065A5066116325 @default.
• W4225792065 hasAuthorship W4225792065A5066881525 @default.
• W4225792065 hasAuthorship W4225792065A5081931838 @default.
• W4225792065 hasAuthorship W4225792065A5085604066 @default.
• W4225792065 hasBestOaLocation W42257920651 @default.
• W4225792065 hasConcept C126322002 @default.
• W4225792065 hasConcept C151730666 @default.
• W4225792065 hasConcept C188816634 @default.
• W4225792065 hasConcept C2778260677 @default.
• W4225792065 hasConcept C2778271842 @default.
• W4225792065 hasConcept C2778292693 @default.
• W4225792065 hasConcept C2779008522 @default.
• W4225792065 hasConcept C2779134260 @default.
• W4225792065 hasConcept C2779802037 @default.
• W4225792065 hasConcept C61716771 @default.
• W4225792065 hasConcept C71924100 @default.
• W4225792065 hasConcept C86803240 @default.
• W4225792065 hasConcept C90924648 @default.
• W4225792065 hasConceptScore W4225792065C126322002 @default.
• W4225792065 hasConceptScore W4225792065C151730666 @default.
• W4225792065 hasConceptScore W4225792065C188816634 @default.
• W4225792065 hasConceptScore W4225792065C2778260677 @default.
• W4225792065 hasConceptScore W4225792065C2778271842 @default.
• W4225792065 hasConceptScore W4225792065C2778292693 @default.
• W4225792065 hasConceptScore W4225792065C2779008522 @default.
• W4225792065 hasConceptScore W4225792065C2779134260 @default.
• W4225792065 hasConceptScore W4225792065C2779802037 @default.
• W4225792065 hasConceptScore W4225792065C61716771 @default.
• W4225792065 hasConceptScore W4225792065C71924100 @default.
• W4225792065 hasConceptScore W4225792065C86803240 @default.
• W4225792065 hasConceptScore W4225792065C90924648 @default.
• W4225792065 hasIssue "Supplement_1" @default.
• W4225792065 hasLocation W42257920651 @default.
• W4225792065 hasOpenAccess W4225792065 @default.
• W4225792065 hasPrimaryLocation W42257920651 @default.
• W4225792065 hasRelatedWork W1741021874 @default.
• W4225792065 hasRelatedWork W1974116373 @default.
• W4225792065 hasRelatedWork W2072766425 @default.
• W4225792065 hasRelatedWork W2344730593 @default.
• W4225792065 hasRelatedWork W2380744585 @default.
• W4225792065 hasRelatedWork W2383717596 @default.
• W4225792065 hasRelatedWork W2393279812 @default.
• W4225792065 hasRelatedWork W4212847486 @default.
• W4225792065 hasRelatedWork W4306903709 @default.
• W4225792065 hasRelatedWork W2536471341 @default.
• W4225792065 hasVolume "16" @default.
• W4225792065 isParatext "false" @default.
• W4225792065 isRetracted "false" @default.
• W4225792065 workType "article" @default.