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- W4225796353 startingPage "213" @default.
- W4225796353 abstract "The manifold actions of the pro-inflammatory and regenerative chemokine CXCL12/SDF-1α are executed through the canonical GProteinCoupledReceptor CXCR4, and the non-canonical ACKR3/CXCR7. Platelets express CXCR4, ACKR3/CXCR7, and are a vital source of CXCL12/SDF-1α themselves. In recent years, a regulatory impact of the CXCL12-CXCR4-CXCR7 axis on platelet biogenesis, i.e., megakaryopoiesis, thrombotic and thrombo-inflammatory actions have been revealed through experimental and clinical studies. Platelet surface expression of ACKR3/CXCR7 is significantly enhanced following myocardial infarction (MI) in acute coronary syndrome (ACS) patients, and is also associated with improved functional recovery and prognosis. The therapeutic implications of ACKR3/CXCR7 in myocardial regeneration and improved recovery following an ischemic episode, are well documented. Cardiomyocytes, cardiac-fibroblasts, endothelial lining of the blood vessels perfusing the heart, besides infiltrating platelets and monocytes, all express ACKR3/CXCR7. This review recapitulates ligand induced differential trafficking of platelet CXCR4-ACKR3/CXCR7 affecting their surface availability, and in regulating thrombo-inflammatory platelet functions and survival through CXCR4 or ACKR3/CXCR7. It emphasizes the pro-thrombotic influence of CXCL12/SDF-1α exerted through CXCR4, as opposed to the anti-thrombotic impact of ACKR3/CXCR7. Offering an innovative translational perspective, this review also discusses the advantages and challenges of utilizing ACKR3/CXCR7 as a potential anti-thrombotic strategy in platelet-associated cardiovascular disorders, particularly in coronary artery disease (CAD) patients post-MI." @default.
- W4225796353 created "2022-05-05" @default.
- W4225796353 creator A5071436332 @default.
- W4225796353 date "2022-01-09" @default.
- W4225796353 modified "2023-09-30" @default.
- W4225796353 title "Atypical Roles of the Chemokine Receptor ACKR3/CXCR7 in Platelet Pathophysiology" @default.
- W4225796353 cites W1503765703 @default.
- W4225796353 cites W1538857721 @default.
- W4225796353 cites W1539398892 @default.
- W4225796353 cites W1793367538 @default.
- W4225796353 cites W1890667195 @default.
- W4225796353 cites W1969027117 @default.
- W4225796353 cites W1973063128 @default.
- W4225796353 cites W1975264481 @default.
- W4225796353 cites W1977091420 @default.
- W4225796353 cites W1980738842 @default.
- W4225796353 cites W1981149366 @default.
- W4225796353 cites W1995656788 @default.
- W4225796353 cites W1997695335 @default.
- W4225796353 cites W1997868017 @default.
- W4225796353 cites W2001798594 @default.
- W4225796353 cites W2002258555 @default.
- W4225796353 cites W2008842656 @default.
- W4225796353 cites W2013627255 @default.
- W4225796353 cites W2024659862 @default.
- W4225796353 cites W2026565203 @default.
- W4225796353 cites W2028488136 @default.
- W4225796353 cites W2030406672 @default.
- W4225796353 cites W2030490621 @default.
- W4225796353 cites W2032468013 @default.
- W4225796353 cites W2032555624 @default.
- W4225796353 cites W2033314236 @default.
- W4225796353 cites W2033426336 @default.
- W4225796353 cites W2034297565 @default.
- W4225796353 cites W2036187245 @default.
- W4225796353 cites W2037787296 @default.
- W4225796353 cites W2048870371 @default.
- W4225796353 cites W2053942776 @default.
- W4225796353 cites W2054312277 @default.
- W4225796353 cites W2054597378 @default.
- W4225796353 cites W2054850265 @default.
- W4225796353 cites W2055998280 @default.
- W4225796353 cites W2056531031 @default.
- W4225796353 cites W2058806710 @default.
- W4225796353 cites W2060392450 @default.
- W4225796353 cites W2060728883 @default.
- W4225796353 cites W2061340549 @default.
- W4225796353 cites W2061712065 @default.
- W4225796353 cites W2061859660 @default.
- W4225796353 cites W2062910590 @default.
- W4225796353 cites W2065334259 @default.
- W4225796353 cites W2073020845 @default.
- W4225796353 cites W2076730304 @default.
- W4225796353 cites W2078191267 @default.
- W4225796353 cites W2080185076 @default.
- W4225796353 cites W2082819432 @default.
- W4225796353 cites W2083642109 @default.
- W4225796353 cites W2087120448 @default.
- W4225796353 cites W2088604735 @default.
- W4225796353 cites W2090989957 @default.
- W4225796353 cites W2092674918 @default.
- W4225796353 cites W2094449383 @default.
- W4225796353 cites W2095102966 @default.
- W4225796353 cites W2103682586 @default.
- W4225796353 cites W2105050461 @default.
- W4225796353 cites W2105468643 @default.
- W4225796353 cites W2106415952 @default.
- W4225796353 cites W2107175727 @default.
- W4225796353 cites W2120067620 @default.
- W4225796353 cites W2122346622 @default.
- W4225796353 cites W2122921041 @default.
- W4225796353 cites W2132274201 @default.
- W4225796353 cites W2136956402 @default.
- W4225796353 cites W2137121530 @default.
- W4225796353 cites W2138354938 @default.
- W4225796353 cites W2141173755 @default.
- W4225796353 cites W2142221381 @default.
- W4225796353 cites W2143063196 @default.
- W4225796353 cites W2145505149 @default.
- W4225796353 cites W2147707433 @default.
- W4225796353 cites W2152221076 @default.
- W4225796353 cites W2153044787 @default.
- W4225796353 cites W2153827357 @default.
- W4225796353 cites W2155560850 @default.
- W4225796353 cites W2159597354 @default.
- W4225796353 cites W2159913536 @default.
- W4225796353 cites W2160471996 @default.
- W4225796353 cites W2161488081 @default.
- W4225796353 cites W2161632137 @default.
- W4225796353 cites W2162289305 @default.
- W4225796353 cites W2166366276 @default.
- W4225796353 cites W2166421867 @default.
- W4225796353 cites W2166905638 @default.
- W4225796353 cites W2170228671 @default.
- W4225796353 cites W2179527818 @default.
- W4225796353 cites W2179689306 @default.
- W4225796353 cites W2180537859 @default.
- W4225796353 cites W2264612298 @default.