FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225797002> ?p ?o ?g. }

• W4225797002 endingPage "148" @default.
• W4225797002 startingPage "139" @default.
• W4225797002 abstract "Pleurodesis is done as an in-patient procedure to control symptomatic recurrent malignant pleural effusion (MPE) and has a success rate of 75-80%. Thoracic ultrasonography has been shown in a small study to predict pleurodesis success early by demonstrating cessation of lung sliding (a normal sign seen in healthy patients, lung sliding indicates normal movement of the lung inside the thorax). We aimed to investigate whether the use of thoracic ultrasonography in pleurodesis pathways could shorten hospital stay in patients with MPE undergoing pleurodesis.The Efficacy of Sonographic and Biological Pleurodesis Indicators of Malignant Pleural Effusion (SIMPLE) trial was an open-label, randomised controlled trial done in ten respiratory centres in the UK and one respiratory centre in the Netherlands. Adult patients (aged ≥18 years) with confirmed MPE who required talc pleurodesis via either a chest tube or as poudrage during medical thorascopy were eligible. Patients were randomly assigned (1:1) to thoracic ultrasonography-guided care or standard care via an online platform using a minimisation algorithm. In the intervention group, daily thoracic ultrasonography examination for lung sliding in nine regions was done to derive an adherence score: present (1 point), questionable (2 points), or absent (3 points), with a lowest possible score of 9 (preserved sliding) and a highest possible score of 27 (complete absence of sliding); the chest tube was removed if the score was more than 20. In the standard care group, tube removal was based on daily output volume (per British Thoracic Society Guidelines). The primary outcome was length of hospital stay, and secondary outcomes were pleurodesis failure at 3 months, time to tube removal, all-cause mortality, symptoms and quality-of-life scores, and cost-effectiveness of thoracic ultrasonography-guided care. All outcomes were assessed in the modified intention-to-treat population (patients with missing data excluded), and a non-inferiority analysis of pleurodesis failure was done in the per-protocol population. This trial was registered with ISRCTN, ISRCTN16441661.Between Dec 31, 2015, and Dec 17, 2019, 778 patients were assessed for eligibility and 313 participants (165 [53%] male) were recruited and randomly assigned to thoracic ultrasonography-guided care (n=159) or standard care (n=154). In the modified intention-to-treat population, the median length of hospital stay was significantly shorter in the intervention group (2 days [IQR 2-4]) than in the standard care group (3 days [2-5]; difference 1 day [95% CI 1-1]; p<0·0001). In the per-protocol analysis, thoracic ultrasonography-guided care was non-inferior to standard care in terms of pleurodesis failure at 3 months, which occurred in 27 (29·7%) of 91 patients in the intervention group versus 34 (31·2%) of 109 patients in the standard care group (risk difference -1·5% [95% CI -10·2% to 7·2%]; non-inferiority margin 15%). Mean time to chest tube removal in the intervention group was 2·4 days (SD 2·5) versus 3·1 days (2·0) in the standard care group (mean difference -0·72 days [95% CI -1·22 to -0·21]; p=0·0057). There were no significant between-group differences in all-cause mortality, symptom scores, or quality-of-life scores, except on the EQ-5D visual analogue scale, which was significantly lower in the standard care group at 3 months. Although costs were similar between the groups, thoracic ultrasonography-guided care was cost-effective compared with standard care.Thoracic ultrasonography-guided care for pleurodesis in patients with MPE results in shorter hospital stay (compared with the British Thoracic Society recommendation for pleurodesis) without reducing the success rate of the procedure at 3 months. The data support consideration of standard use of thoracic ultrasonography in patients undergoing MPE-related pleurodesis.Marie Curie Cancer Care Committee." @default.
• W4225797002 created "2022-05-05" @default.
• W4225797002 creator A5000868546 @default.
• W4225797002 creator A5002693238 @default.
• W4225797002 creator A5010081088 @default.
• W4225797002 creator A5013240461 @default.
• W4225797002 creator A5018641575 @default.
• W4225797002 creator A5021002284 @default.
• W4225797002 creator A5023335403 @default.
• W4225797002 creator A5023957322 @default.
• W4225797002 creator A5030430174 @default.
• W4225797002 creator A5036416966 @default.
• W4225797002 creator A5036990987 @default.
• W4225797002 creator A5044496888 @default.
• W4225797002 creator A5046185271 @default.
• W4225797002 creator A5048009571 @default.
• W4225797002 creator A5049329206 @default.
• W4225797002 creator A5053583791 @default.
• W4225797002 creator A5057031525 @default.
• W4225797002 creator A5057249205 @default.
• W4225797002 creator A5059272486 @default.
• W4225797002 creator A5060769620 @default.
• W4225797002 creator A5061110223 @default.
• W4225797002 creator A5066647760 @default.
• W4225797002 creator A5072934006 @default.
• W4225797002 creator A5074598198 @default.
• W4225797002 creator A5075349431 @default.
• W4225797002 creator A5075986424 @default.
• W4225797002 creator A5080643221 @default.
• W4225797002 creator A5081633297 @default.
• W4225797002 creator A5082693401 @default.
• W4225797002 creator A5087425749 @default.
• W4225797002 creator A5091586566 @default.
• W4225797002 date "2022-02-01" @default.
• W4225797002 modified "2023-10-07" @default.
• W4225797002 title "Role of thoracic ultrasonography in pleurodesis pathways for malignant pleural effusions (SIMPLE): an open-label, randomised controlled trial" @default.
• W4225797002 cites W1691766376 @default.
• W4225797002 cites W1944848646 @default.
• W4225797002 cites W1966849311 @default.
• W4225797002 cites W1975166857 @default.
• W4225797002 cites W2013564592 @default.
• W4225797002 cites W2067133579 @default.
• W4225797002 cites W2118051530 @default.
• W4225797002 cites W2123080390 @default.
• W4225797002 cites W2133621533 @default.
• W4225797002 cites W2170829864 @default.
• W4225797002 cites W2213657668 @default.
• W4225797002 cites W2554915312 @default.
• W4225797002 cites W2559297711 @default.
• W4225797002 cites W2751449255 @default.
• W4225797002 cites W2770388669 @default.
• W4225797002 cites W2795716722 @default.
• W4225797002 cites W2808492717 @default.
• W4225797002 cites W2884284882 @default.
• W4225797002 cites W2884606331 @default.
• W4225797002 cites W2892255225 @default.
• W4225797002 cites W2894749894 @default.
• W4225797002 cites W2912178449 @default.
• W4225797002 cites W2992951617 @default.
• W4225797002 cites W3012257306 @default.
• W4225797002 cites W3022291641 @default.
• W4225797002 cites W3024037381 @default.
• W4225797002 cites W3026524474 @default.
• W4225797002 cites W3087599725 @default.
• W4225797002 doi "https://doi.org/10.1016/s2213-2600(21)00353-2" @default.
• W4225797002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34634246" @default.
• W4225797002 hasPublicationYear "2022" @default.
• W4225797002 type Work @default.
• W4225797002 citedByCount "11" @default.
• W4225797002 countsByYear W42257970022022 @default.
• W4225797002 countsByYear W42257970022023 @default.
• W4225797002 crossrefType "journal-article" @default.
• W4225797002 hasAuthorship W4225797002A5000868546 @default.
• W4225797002 hasAuthorship W4225797002A5002693238 @default.
• W4225797002 hasAuthorship W4225797002A5010081088 @default.
• W4225797002 hasAuthorship W4225797002A5013240461 @default.
• W4225797002 hasAuthorship W4225797002A5018641575 @default.
• W4225797002 hasAuthorship W4225797002A5021002284 @default.
• W4225797002 hasAuthorship W4225797002A5023335403 @default.
• W4225797002 hasAuthorship W4225797002A5023957322 @default.
• W4225797002 hasAuthorship W4225797002A5030430174 @default.
• W4225797002 hasAuthorship W4225797002A5036416966 @default.
• W4225797002 hasAuthorship W4225797002A5036990987 @default.
• W4225797002 hasAuthorship W4225797002A5044496888 @default.
• W4225797002 hasAuthorship W4225797002A5046185271 @default.
• W4225797002 hasAuthorship W4225797002A5048009571 @default.
• W4225797002 hasAuthorship W4225797002A5049329206 @default.
• W4225797002 hasAuthorship W4225797002A5053583791 @default.
• W4225797002 hasAuthorship W4225797002A5057031525 @default.
• W4225797002 hasAuthorship W4225797002A5057249205 @default.
• W4225797002 hasAuthorship W4225797002A5059272486 @default.
• W4225797002 hasAuthorship W4225797002A5060769620 @default.
• W4225797002 hasAuthorship W4225797002A5061110223 @default.
• W4225797002 hasAuthorship W4225797002A5066647760 @default.
• W4225797002 hasAuthorship W4225797002A5072934006 @default.
• W4225797002 hasAuthorship W4225797002A5074598198 @default.
• W4225797002 hasAuthorship W4225797002A5075349431 @default.
• W4225797002 hasAuthorship W4225797002A5075986424 @default.

• next