Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225797030> ?p ?o ?g. }
- W4225797030 abstract "Bacterial small RNAs (sRNAs) contribute to a variety of regulatory mechanisms that modulate a wide range of pathways, including metabolism, virulence, and antibiotic resistance. We investigated the involvement of sRNAs in rifampicin resistance in the opportunistic pathogen Staphylococcus aureus. Using a competition assay with an sRNA mutant library, we identified 6S RNA as being required for protection against low concentrations of rifampicin, an RNA polymerase (RNAP) inhibitor. This effect applied to rifabutin and fidaxomicin, two other RNAP-targeting antibiotics. 6S RNA is highly conserved in bacteria, and its absence in two other major pathogens, Salmonella enterica and Clostridioides difficile, also impaired susceptibility to RNAP inhibitors. In S. aureus, 6S RNA is produced from an autonomous gene and accumulates in stationary phase. In contrast to what was reported for Escherichia coli, S. aureus 6S RNA does not appear to play a critical role in the transition from exponential to stationary phase but affects σB-regulated expression in prolonged stationary phase. Nevertheless, its protective effect against rifampicin is independent of alternative sigma factor σB activity. Our results suggest that 6S RNA helps maintain RNAP-σA integrity in S. aureus, which could in turn help bacteria withstand low concentrations of RNAP inhibitors." @default.
- W4225797030 created "2022-05-05" @default.
- W4225797030 creator A5020554149 @default.
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- W4225797030 creator A5080333951 @default.
- W4225797030 date "2022-05-17" @default.
- W4225797030 modified "2023-10-16" @default.
- W4225797030 title "6S RNA-Dependent Susceptibility to RNA Polymerase Inhibitors" @default.
- W4225797030 cites W1488701566 @default.
- W4225797030 cites W1529969086 @default.
- W4225797030 cites W1878404532 @default.
- W4225797030 cites W1900505923 @default.
- W4225797030 cites W1922930809 @default.
- W4225797030 cites W1969939375 @default.
- W4225797030 cites W1972573548 @default.
- W4225797030 cites W1978663080 @default.
- W4225797030 cites W1979973356 @default.
- W4225797030 cites W1982777646 @default.
- W4225797030 cites W1989534009 @default.
- W4225797030 cites W1990046762 @default.
- W4225797030 cites W1992986900 @default.
- W4225797030 cites W1996035684 @default.
- W4225797030 cites W2001696799 @default.
- W4225797030 cites W2004252769 @default.
- W4225797030 cites W2006805047 @default.
- W4225797030 cites W2008643214 @default.
- W4225797030 cites W2015977256 @default.
- W4225797030 cites W2029348973 @default.
- W4225797030 cites W2033026452 @default.
- W4225797030 cites W2037461115 @default.
- W4225797030 cites W2038231155 @default.
- W4225797030 cites W2038809697 @default.
- W4225797030 cites W2039508595 @default.
- W4225797030 cites W2040148360 @default.
- W4225797030 cites W2044618828 @default.
- W4225797030 cites W2055506322 @default.
- W4225797030 cites W2062802692 @default.
- W4225797030 cites W2067948873 @default.
- W4225797030 cites W2068372433 @default.
- W4225797030 cites W2081073001 @default.
- W4225797030 cites W2082553170 @default.
- W4225797030 cites W2082965031 @default.
- W4225797030 cites W2083433373 @default.
- W4225797030 cites W2089198524 @default.
- W4225797030 cites W2091044669 @default.
- W4225797030 cites W2096049571 @default.
- W4225797030 cites W2097493383 @default.
- W4225797030 cites W2098508116 @default.
- W4225797030 cites W2103056313 @default.
- W4225797030 cites W2109219778 @default.
- W4225797030 cites W2110763275 @default.
- W4225797030 cites W2111512612 @default.
- W4225797030 cites W2115263303 @default.
- W4225797030 cites W2116017762 @default.
- W4225797030 cites W2116137883 @default.
- W4225797030 cites W2119278807 @default.
- W4225797030 cites W2122192796 @default.
- W4225797030 cites W2127582460 @default.
- W4225797030 cites W2130407230 @default.
- W4225797030 cites W2130512803 @default.
- W4225797030 cites W2135673226 @default.
- W4225797030 cites W2140187633 @default.
- W4225797030 cites W2140591243 @default.
- W4225797030 cites W2141474738 @default.
- W4225797030 cites W2143907677 @default.
- W4225797030 cites W2147057508 @default.
- W4225797030 cites W2154896818 @default.
- W4225797030 cites W2160006457 @default.
- W4225797030 cites W2163781079 @default.
- W4225797030 cites W2169614539 @default.
- W4225797030 cites W2169781795 @default.
- W4225797030 cites W2179438025 @default.
- W4225797030 cites W2217917186 @default.
- W4225797030 cites W2227544360 @default.
- W4225797030 cites W2239954133 @default.
- W4225797030 cites W2314649741 @default.
- W4225797030 cites W2322749552 @default.
- W4225797030 cites W2397790962 @default.
- W4225797030 cites W2401064884 @default.
- W4225797030 cites W2516700361 @default.
- W4225797030 cites W2547755118 @default.
- W4225797030 cites W2559011085 @default.
- W4225797030 cites W2588370254 @default.
- W4225797030 cites W2774433577 @default.
- W4225797030 cites W2781904465 @default.
- W4225797030 cites W2788073388 @default.
- W4225797030 cites W2799907054 @default.
- W4225797030 cites W2808346089 @default.
- W4225797030 cites W2901070409 @default.
- W4225797030 cites W2940015645 @default.
- W4225797030 cites W3012937271 @default.
- W4225797030 cites W3013725920 @default.
- W4225797030 cites W3049402265 @default.
- W4225797030 cites W3082231373 @default.
- W4225797030 cites W3097612522 @default.