Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225816450> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W4225816450 abstract "Abstract Objective Recently, the Omicron strain of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread and replaced the previously dominant Delta strain. Several Omicron sublineages (BA.1, BA.1.1 and BA.2) have been identified, with in vitro and preclinical reports showing that the pathogenicity and therapeutic efficacy differs between BA.1 and BA.2. We sought to develop a TaqMan assay to identify these subvariants. Methods A TaqMan assay was constructed for rapid identification and genotyping of Omicron sublineages. We analyzed three characteristic mutations of the spike gene, Δ69–70, G339D and Q493R, by TaqMan assay. The accuracy of the TaqMan assay was examined by comparing its results with the results of whole genome sequencing (WGS) analysis. Results A total of 169 SARS-CoV-2 positive samples were analyzed by WGS and TaqMan assay. The 127 samples determined as BA.1/BA.1.1 by WGS were all positive for Δ69–70, G339D and Q493R by TaqMan assay. Forty-two samples determined as BA.2 by WGS were negative for Δ69–70 but positive for G339D and Q493R by TaqMan. The concordance rate between WGS and the TaqMan assay was 100% (169/169). Conclusion TaqMan assays targeting characteristic mutations are useful for identification and discrimination of Omicron sublineages." @default.
- W4225816450 created "2022-05-05" @default.
- W4225816450 creator A5000601248 @default.
- W4225816450 creator A5001342594 @default.
- W4225816450 creator A5014408489 @default.
- W4225816450 creator A5016283693 @default.
- W4225816450 creator A5034244372 @default.
- W4225816450 creator A5044032052 @default.
- W4225816450 creator A5046049994 @default.
- W4225816450 creator A5053797248 @default.
- W4225816450 creator A5054179805 @default.
- W4225816450 creator A5064362255 @default.
- W4225816450 creator A5071650784 @default.
- W4225816450 creator A5090461473 @default.
- W4225816450 date "2022-04-05" @default.
- W4225816450 modified "2023-10-03" @default.
- W4225816450 title "Classification of Omicron BA.1, BA.1.1 and BA.2 sublineages by TaqMan assay consistent with whole genome analysis data" @default.
- W4225816450 cites W2509439934 @default.
- W4225816450 cites W2605343262 @default.
- W4225816450 cites W3004280078 @default.
- W4225816450 cites W3021283406 @default.
- W4225816450 cites W3039985320 @default.
- W4225816450 cites W3043124965 @default.
- W4225816450 cites W3048917590 @default.
- W4225816450 cites W3127856892 @default.
- W4225816450 cites W3133975993 @default.
- W4225816450 cites W3170677418 @default.
- W4225816450 cites W3196531163 @default.
- W4225816450 cites W3201572724 @default.
- W4225816450 cites W4200112411 @default.
- W4225816450 cites W4200469371 @default.
- W4225816450 cites W4200587241 @default.
- W4225816450 cites W4211188325 @default.
- W4225816450 cites W4211251118 @default.
- W4225816450 cites W4212931798 @default.
- W4225816450 cites W4213171525 @default.
- W4225816450 cites W4214657299 @default.
- W4225816450 cites W4214811188 @default.
- W4225816450 cites W4214825353 @default.
- W4225816450 cites W4214861017 @default.
- W4225816450 cites W4220806816 @default.
- W4225816450 cites W4225553089 @default.
- W4225816450 cites W4226164088 @default.
- W4225816450 cites W4226491433 @default.
- W4225816450 doi "https://doi.org/10.1101/2022.04.03.22273268" @default.
- W4225816450 hasPublicationYear "2022" @default.
- W4225816450 type Work @default.
- W4225816450 citedByCount "3" @default.
- W4225816450 countsByYear W42258164502022 @default.
- W4225816450 crossrefType "posted-content" @default.
- W4225816450 hasAuthorship W4225816450A5000601248 @default.
- W4225816450 hasAuthorship W4225816450A5001342594 @default.
- W4225816450 hasAuthorship W4225816450A5014408489 @default.
- W4225816450 hasAuthorship W4225816450A5016283693 @default.
- W4225816450 hasAuthorship W4225816450A5034244372 @default.
- W4225816450 hasAuthorship W4225816450A5044032052 @default.
- W4225816450 hasAuthorship W4225816450A5046049994 @default.
- W4225816450 hasAuthorship W4225816450A5053797248 @default.
- W4225816450 hasAuthorship W4225816450A5054179805 @default.
- W4225816450 hasAuthorship W4225816450A5064362255 @default.
- W4225816450 hasAuthorship W4225816450A5071650784 @default.
- W4225816450 hasAuthorship W4225816450A5090461473 @default.
- W4225816450 hasBestOaLocation W42258164501 @default.
- W4225816450 hasConcept C104317684 @default.
- W4225816450 hasConcept C135763542 @default.
- W4225816450 hasConcept C143660080 @default.
- W4225816450 hasConcept C153911025 @default.
- W4225816450 hasConcept C160798450 @default.
- W4225816450 hasConcept C31467283 @default.
- W4225816450 hasConcept C48023723 @default.
- W4225816450 hasConcept C54355233 @default.
- W4225816450 hasConcept C86803240 @default.
- W4225816450 hasConceptScore W4225816450C104317684 @default.
- W4225816450 hasConceptScore W4225816450C135763542 @default.
- W4225816450 hasConceptScore W4225816450C143660080 @default.
- W4225816450 hasConceptScore W4225816450C153911025 @default.
- W4225816450 hasConceptScore W4225816450C160798450 @default.
- W4225816450 hasConceptScore W4225816450C31467283 @default.
- W4225816450 hasConceptScore W4225816450C48023723 @default.
- W4225816450 hasConceptScore W4225816450C54355233 @default.
- W4225816450 hasConceptScore W4225816450C86803240 @default.
- W4225816450 hasLocation W42258164501 @default.
- W4225816450 hasOpenAccess W4225816450 @default.
- W4225816450 hasPrimaryLocation W42258164501 @default.
- W4225816450 hasRelatedWork W2004827278 @default.
- W4225816450 hasRelatedWork W2032525209 @default.
- W4225816450 hasRelatedWork W2119210416 @default.
- W4225816450 hasRelatedWork W2163800959 @default.
- W4225816450 hasRelatedWork W2192990808 @default.
- W4225816450 hasRelatedWork W2362684431 @default.
- W4225816450 hasRelatedWork W2382588739 @default.
- W4225816450 hasRelatedWork W2463772984 @default.
- W4225816450 hasRelatedWork W2964710295 @default.
- W4225816450 hasRelatedWork W3174753395 @default.
- W4225816450 isParatext "false" @default.
- W4225816450 isRetracted "false" @default.
- W4225816450 workType "article" @default.