Matches in SemOpenAlex for { <https://semopenalex.org/work/W4225832331> ?p ?o ?g. }
- W4225832331 abstract "The use of silver nanoparticles (AgNPs) embedded in polymeric matrix has acquired special attention as a strategy to reduce metal toxicity without losing its antimicrobial effect. In this work, the green synthesis of AgNPs and their functionalization with chitosan (AgNPs@Chi) was performed, and their antifungal activity investigated against the foremost species responsible for causing sporotrichosis, Sporothrix brasiliensis and Sporothrix schenckii . In vitro studies revealed inhibitory concentrations ranging from 0.12–1 μg/ml for both nanocomposites (NCs). Silver release in suspension displayed chitosan as a potential vehicle for continuous silver discharge, with a complete release after 52 days. No synergistic effects were observed in vitro when the NCs were combined with itraconazole or amphotericin B. Treatment of S. brasiliensis with NCs caused morphological deformities, cell membrane discontinuity and an intense cytoplasmic degeneration. Remarkably, both NCs induced the growth and migration of keratinocytes and fibroblasts when compared to control conditions. In addition, functionalization of AgNPs with chitosan significantly reduced its hemolytic activity, suggesting their potential use in vivo . Finally, silver nanocomposites were used as a daily topical treatment in a murine model of subcutaneous sporotrichosis, showing the ability to reduce the Sporothrix infection and stimulate tissue repair. In combination, our results demonstrate that AgNPs@Chi can be a non-toxic and efficient alternative for sporotrichosis." @default.
- W4225832331 created "2022-05-05" @default.
- W4225832331 creator A5005930546 @default.
- W4225832331 creator A5014536558 @default.
- W4225832331 creator A5030117691 @default.
- W4225832331 creator A5083449358 @default.
- W4225832331 date "2022-04-08" @default.
- W4225832331 modified "2023-10-12" @default.
- W4225832331 title "Silver Chitosan Nanocomposites are Effective to Combat Sporotrichosis" @default.
- W4225832331 cites W1748422601 @default.
- W4225832331 cites W1846505747 @default.
- W4225832331 cites W1880773756 @default.
- W4225832331 cites W1965583968 @default.
- W4225832331 cites W1991149656 @default.
- W4225832331 cites W2008122854 @default.
- W4225832331 cites W2020398834 @default.
- W4225832331 cites W2030728789 @default.
- W4225832331 cites W2033430140 @default.
- W4225832331 cites W2044545660 @default.
- W4225832331 cites W2066685510 @default.
- W4225832331 cites W2067017937 @default.
- W4225832331 cites W2070559784 @default.
- W4225832331 cites W2073069163 @default.
- W4225832331 cites W2086170372 @default.
- W4225832331 cites W2094652313 @default.
- W4225832331 cites W2095042704 @default.
- W4225832331 cites W2096211831 @default.
- W4225832331 cites W2100593340 @default.
- W4225832331 cites W2100767817 @default.
- W4225832331 cites W2101611517 @default.
- W4225832331 cites W2110409529 @default.
- W4225832331 cites W2124129595 @default.
- W4225832331 cites W2126827403 @default.
- W4225832331 cites W2140134181 @default.
- W4225832331 cites W2159356721 @default.
- W4225832331 cites W2220528754 @default.
- W4225832331 cites W2321048089 @default.
- W4225832331 cites W2333223910 @default.
- W4225832331 cites W2394856704 @default.
- W4225832331 cites W2396747981 @default.
- W4225832331 cites W2519678626 @default.
- W4225832331 cites W2520930988 @default.
- W4225832331 cites W2533928893 @default.
- W4225832331 cites W2548519955 @default.
- W4225832331 cites W2549644565 @default.
- W4225832331 cites W2552921753 @default.
- W4225832331 cites W2559853894 @default.
- W4225832331 cites W2575866266 @default.
- W4225832331 cites W2612901137 @default.
- W4225832331 cites W2621645467 @default.
- W4225832331 cites W2735737470 @default.
- W4225832331 cites W2752164271 @default.
- W4225832331 cites W2752909749 @default.
- W4225832331 cites W2768639053 @default.
- W4225832331 cites W2791192993 @default.
- W4225832331 cites W2791193377 @default.
- W4225832331 cites W2800657209 @default.
- W4225832331 cites W2803042846 @default.
- W4225832331 cites W2808711858 @default.
- W4225832331 cites W2887265015 @default.
- W4225832331 cites W2895715996 @default.
- W4225832331 cites W2895800764 @default.
- W4225832331 cites W2897417405 @default.
- W4225832331 cites W2897719374 @default.
- W4225832331 cites W2897775224 @default.
- W4225832331 cites W2898313138 @default.
- W4225832331 cites W2906236697 @default.
- W4225832331 cites W2908748476 @default.
- W4225832331 cites W2911517174 @default.
- W4225832331 cites W2923406305 @default.
- W4225832331 cites W2942999779 @default.
- W4225832331 cites W2947980183 @default.
- W4225832331 cites W2962866293 @default.
- W4225832331 cites W2964993739 @default.
- W4225832331 cites W2967136546 @default.
- W4225832331 cites W2980759146 @default.
- W4225832331 cites W2981371463 @default.
- W4225832331 cites W3004164284 @default.
- W4225832331 cites W3004801139 @default.
- W4225832331 cites W3005781882 @default.
- W4225832331 cites W3013319894 @default.
- W4225832331 cites W3046444323 @default.
- W4225832331 cites W3090961120 @default.
- W4225832331 cites W3130655990 @default.
- W4225832331 cites W3164855797 @default.
- W4225832331 cites W3174879051 @default.
- W4225832331 cites W816719050 @default.
- W4225832331 doi "https://doi.org/10.3389/fnano.2022.857681" @default.
- W4225832331 hasPublicationYear "2022" @default.
- W4225832331 type Work @default.
- W4225832331 citedByCount "4" @default.
- W4225832331 countsByYear W42258323312022 @default.
- W4225832331 countsByYear W42258323312023 @default.
- W4225832331 crossrefType "journal-article" @default.
- W4225832331 hasAuthorship W4225832331A5005930546 @default.
- W4225832331 hasAuthorship W4225832331A5014536558 @default.
- W4225832331 hasAuthorship W4225832331A5030117691 @default.
- W4225832331 hasAuthorship W4225832331A5083449358 @default.
- W4225832331 hasBestOaLocation W42258323311 @default.
- W4225832331 hasConcept C150903083 @default.