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- W4225861566 abstract "The overarching objective is to review how early exposure to adversity interacts with inflammation to alter brain maturation. Both adversity and inflammation are significant risk factors for psychopathology. Literature relevant to the effects of adversity in children and adolescents on brain development is reviewed. These studies are supported by research in animals exposed to species-relevant stressors during development. While it is known that exposure to adversity at any age increases inflammation, the effects of inflammation are exacerbated at developmental stages when the immature brain is uniquely sensitive to experiences. Microglia play a vital role in this process, as they scavenge cellular debris and prune synapses to optimize performance. In essence, microglia modify the synapse to match environmental demands, which is necessary for someone with a history of adversity. Overall, by piecing together clinical and preclinical research areas, what emerges is a picture of how adversity uniquely sculpts the brain. Microglia interactions with the inhibitory neurotransmitter GABA (specifically, the subtype expressing parvalbumin) are discussed within contexts of development and adversity. A review of inflammation markers in individuals with a history of abuse is combined with preclinical studies to describe their effects on maturation. Inconsistencies within the literature are discussed, with a call for standardizing methodologies relating to the age of assessing adversity effects, measures to quantify stress and inflammation, and more brain-based measures of biochemistry. Preclinical studies pave the way for interventions using anti-inflammation-based agents (COX-2 inhibitors, CB2 agonists, meditation/yoga) by identifying where, when, and how the developmental trajectory goes awry." @default.
- W4225861566 created "2022-05-05" @default.
- W4225861566 creator A5012854700 @default.
- W4225861566 date "2022-01-01" @default.
- W4225861566 modified "2023-10-14" @default.
- W4225861566 title "Neuroinflammation, Early-Life Adversity, and Brain Development" @default.
- W4225861566 cites W1477485773 @default.
- W4225861566 cites W1517894640 @default.
- W4225861566 cites W1601370958 @default.
- W4225861566 cites W1608593799 @default.
- W4225861566 cites W1635624710 @default.
- W4225861566 cites W1940341044 @default.
- W4225861566 cites W1948687830 @default.
- W4225861566 cites W1964801856 @default.
- W4225861566 cites W1965666333 @default.
- W4225861566 cites W1965840063 @default.
- W4225861566 cites W1968700646 @default.
- W4225861566 cites W1968731032 @default.
- W4225861566 cites W1968732298 @default.
- W4225861566 cites W1968740815 @default.
- W4225861566 cites W1972307586 @default.
- W4225861566 cites W1972675191 @default.
- W4225861566 cites W1973187560 @default.
- W4225861566 cites W1974907373 @default.
- W4225861566 cites W1975084599 @default.
- W4225861566 cites W1975588273 @default.
- W4225861566 cites W1975823070 @default.
- W4225861566 cites W1980789245 @default.
- W4225861566 cites W1981459575 @default.
- W4225861566 cites W1984103995 @default.
- W4225861566 cites W1985543379 @default.
- W4225861566 cites W1990487655 @default.
- W4225861566 cites W1991712344 @default.
- W4225861566 cites W1991820507 @default.
- W4225861566 cites W1993259058 @default.
- W4225861566 cites W1993741388 @default.
- W4225861566 cites W1995552285 @default.
- W4225861566 cites W1996055705 @default.
- W4225861566 cites W1996765130 @default.
- W4225861566 cites W1998973288 @default.
- W4225861566 cites W1999069947 @default.
- W4225861566 cites W1999813155 @default.
- W4225861566 cites W2000833088 @default.
- W4225861566 cites W2005886168 @default.
- W4225861566 cites W2008330887 @default.
- W4225861566 cites W2009780891 @default.
- W4225861566 cites W2011811675 @default.
- W4225861566 cites W2012193564 @default.
- W4225861566 cites W2012761545 @default.
- W4225861566 cites W2013906894 @default.
- W4225861566 cites W2015829020 @default.
- W4225861566 cites W2017876495 @default.
- W4225861566 cites W2018529141 @default.
- W4225861566 cites W2019372874 @default.
- W4225861566 cites W2021877988 @default.
- W4225861566 cites W2023448665 @default.
- W4225861566 cites W2023467429 @default.
- W4225861566 cites W2028312992 @default.
- W4225861566 cites W2028367166 @default.
- W4225861566 cites W2028934136 @default.
- W4225861566 cites W2029267876 @default.
- W4225861566 cites W2031964073 @default.
- W4225861566 cites W2032089725 @default.
- W4225861566 cites W2032412398 @default.
- W4225861566 cites W2033617297 @default.
- W4225861566 cites W2034423905 @default.
- W4225861566 cites W2035557202 @default.
- W4225861566 cites W2037929058 @default.
- W4225861566 cites W2043257604 @default.
- W4225861566 cites W2043590800 @default.
- W4225861566 cites W2043961643 @default.
- W4225861566 cites W2047581866 @default.
- W4225861566 cites W2048168580 @default.
- W4225861566 cites W2049730142 @default.
- W4225861566 cites W2049840063 @default.
- W4225861566 cites W2050035705 @default.
- W4225861566 cites W2050618347 @default.
- W4225861566 cites W2054692302 @default.
- W4225861566 cites W2055545132 @default.
- W4225861566 cites W2057455559 @default.
- W4225861566 cites W2057997718 @default.
- W4225861566 cites W2059746446 @default.
- W4225861566 cites W2060061788 @default.
- W4225861566 cites W2060345189 @default.
- W4225861566 cites W2060968640 @default.
- W4225861566 cites W2062298786 @default.
- W4225861566 cites W2062405004 @default.
- W4225861566 cites W2062989629 @default.
- W4225861566 cites W2063146823 @default.
- W4225861566 cites W2063620427 @default.
- W4225861566 cites W2065917711 @default.
- W4225861566 cites W2066943555 @default.
- W4225861566 cites W2067499927 @default.
- W4225861566 cites W2068481683 @default.
- W4225861566 cites W2071196441 @default.
- W4225861566 cites W2071649287 @default.
- W4225861566 cites W2076561167 @default.
- W4225861566 cites W2077269712 @default.